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Fei Chen received his B.S. degree from Shandong University in 2009 and M.S. degree from Fudan University in 2012. In 2018, he completed his Ph.D. at Northwestern University Feinberg School of Medicine. He then joined Memorial Sloan Kettering Cancer Center and finished his postdoctoral training at the end of 2019. Afterwards, He was recruited to Shanghai Cancer Institute and Institute of Biomedical Sciences at Fudan University as a group leader.
Transcription is an elaborate, multistep process that involves a diverse network of transcriptional machinery decoding the genetic and epigenetic information stored in chromatin. As such, miscommunication between transcriptional machinery and chromatin can induce transcriptional deregulation that perturbs physiological functions and, when accumulated to certain extent, causes disease including cancer. Whole-genome sequencing studies have identified human cancers to harbor frequent mutations of transcription factors, transcriptional signaling pathways and epigenetic regulators, highlighting the implication of transcriptional and epigenetic dysregulation in cancer. In our lab, we strive to understand what are the principles of communication between transcriptional machinery and chromatin, why the deregulation of transcriptional regulators can alter gene expression, and how to intervene and rectify this miscommunication to alleviate or even cure disease. We aim to pursue interdisciplinary studies by using a host of different approaches in cancer biology, genetics and epigenetics, biochemistry, bioinformatics and functional genomics, with the ultimate goal to benefit patients and the community.
