Shuang TANG MD,PhD, MHSc E-mail: tangshuang@fudan.edu.cn Lab Website：https://www.x-mol.com/groups/tang_shuang

Dr. Tang received her Medical Degree in 2009 from Shanghai Jiao Tong University School of Medicine. From 2009 to 2015, she completed her Graduate Parternership Program between National institutes of Health in US and Shanghai Jiao Tong University School of Medicine, and received her PhD of Medicine in Nuclear Medicine and Metabolism in July 2015. After that, Shuang stayed in NIH for postdoctoral training, and meanwhile received her Master Degree of Health Science in Clinical Research from Duke University School of Medicine in 2018. After being fully equipped for translational research, Dr. Tang joined Dana-Farber Cancer Institute, Harvard Medical School as a research fellow in 2018 to work on metabolic regulation in women cancer. From 2020, Dr. Tang started her independent academic career as a Principal Investigator and Physician Scientist in Fudan University Shanghai Cancer Center.

Dr. Tang's research focuses on metabolism and nuclear medicine. Using isotope labeling methods together with multi-pronged approaches in cell biology, molecular biology, metabolomics, and mouse models, Dr. Tang's group aim to understand how metabolism and protein modifications regulate the adaptation of fast-proliferating cells (stem cells and cancer cells) to microenvironment, and translate the knowledge for early diagnosis and precise monitoring of cancer by combining with metabolic molecular imaging. So far, her representative academic achievements have been published in top journals such as Molecular cell (2014, 2018), EMBO Journal (2017), Trends in Endocrinology & Metabolism (2019), Cell Metabolism (2020). Based on the significance of her discoveries, Dr. Tang received NIH Women Scientist Advisors (WSA) Scholar Award (one of the two final recipients) in 2017, and Helen Gurley Brown Presidential Initiative Award in 2018. 

Selected Publications:

1. Tang S, Huang G^*, Fan W, Chen Y, Ward JM, Xu X, Xu Q, Kang A, McBurney MW, Fargo DC, Hu G, Baumgart-Vogt E, Zhao Y, Li X^*. SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation. Molecular Cell. 2014 Sep 18; 55(6):843-855.
2. Crowley M, Diamantidis C, McDuffie J, Cameron CB, Stanifer JW, Mock CK, Wang X, Tang S, Nagi A, Kosinski AS, Williams JW^*. Clinical Outcomes of Metformin Use in Populations with Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review. Annals of internal medicine. 2017 Feb 7; 166(3):191-200.
3. Tang S, Fang Y, Huang G, Xu X, Padilla-Banks E, Fan W, Xu Q, Sanderson SM, Foley JF, Dowdy S, McBurney MW, Fargo DC, Williams CJ, Locasale JW, Guan Z, Li X^*. Methionine is essential for SIRT1-regulated mESC maintenance and embryonic development. EMBO Journal. 2017 Nov 2; 36(21):3175-3193.
4. Huang H^#, Tang S^#, Jing M#, Tang Z, Shimada M, Liu X, Qi S, Locasale J, Roeder R, Zhao Y^*, and Li X^*. p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. Molecular Cell. 2018 May 17; 70:663-678.
5. Fang Y^#, Tang S^#, Li X^*. Sirtuins in Metabolic and Epigenetic Regulation of Stem Cells. Trends in Endocrinology & Metabolism. 2019 Mar; 30(3):177-188.
6. Tang S，Li X^*，Locasale J^*. Dietary Methionine in T Cell Biology and Autoimmune Disease. Cell Metabolism. 2020 Feb 4;31(2):211-212.
7. Fan W, Tang S, Fan X, Fang Y, Xu X, Li L, Xu J, Li J, Wang Z^*, Li X^*. SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B. Elife. 2021 May 27; 10:e67452.
8. Liu Y^#, Zhou Q^#, Song S^*, Tang S^*. Integrating metabolic reprogramming and metabolic imaging to predict breast cancer therapeutic responses. Trends in Endocrinology & Metabolism.  2021 Oct; 32(10):762-775.