PhD, Professor, doctoral tutor. Oriental scholar tracking plan and Shanghai City Health Bureau of outstanding academic leaders. I was graduated from Bengbu Medical College of Anhui Province in 1994 in medical laboratory. I received a master's degree in Microbiology and a doctor's degree in biochemistry and molecular biology from the Medical College of Shanghai Jiaotong University in 1997 and 2002 respectively. In January 2009, I engaged in postdoctoral research in the United States in 2003 and returned to China as a laboratory PI.

Research Focus:

1. The mechanism underlying Hypermethylated in cancer 1(HIC1) in tumorigenesis and metastasis;

2. The mechanism and effect of microenvironment heterogeneity in prostate cancer;

3. Coal mine dust prevention and control and occupational safety and health.

Selected Publications:

1. Mu M^# , Li B^#, Zou YJ, Wang WY, Cao HB, Zhang YJ, Sun QX, Chen HM, Ge DY, Tao HH, Hu D, Yuan L^*, Tao XR^*, Wang JH^*. Coal dust exposure triggers heterogeneity of transcriptional profiles in mouse pneumoconiosis and Vitamin D remedies. Particle and Fibre Toxicology. 2022 Jan 20; 1 9(1):7.
2. Chen SJ^#, Zhu GH^#, Yang Y^#, Wang FB^#, Xiao YT, Zhang N, Bian XJ, Zhu YS, Yu YW, Liu F, Dong KQ, Zhang B, Chen WD, Wang C, Chen D, Guo QH, Yi ZF, Liu MY, Fraser M, Kwast TV, Jiang Z, Wang JH*, He HS*, Ren SC*. Single cell analysis reveals onset of multiple progression associated transcriptomic remodellings in prostate cancer. Nature Cell Biology. 2021 Jan; 23:87-98. Highlights published in this issue (Nature Cell Biology. 2021, 23:3-5)
3. Yao MF^#, Shi XL^#, Li Y^#, Xiao YT, Butler W, Huang YQ, Du LL, Wu TQ, Bian XJ, Shi GH, Fu GH, Ye DW^*, Wang JH^*, Ren SC^*. LINC00675 activates androgen receptor axis signaling pathway to promote castration resistant prostate cancer progression. Cell Death & Disease. 2020 Aug 15; 11(8):638.
4. Liang Y^#, Hou LD^#, Li LJ, Li L, Zhu LM, Wang Y, Huang X, Hou YC, Zhu DX, Zou HM, Gu Y, Weng XL, Wang YY, Wu TQ, Yao MF, Gross I, Gaiddon C, Luo M *, Wang JH*, Meng XJ*. Dichloroacetate restores colorectal cancer chemosensitivity through p53/miR-149-3p/PDK2-mediated glucose metabolism pathway. Oncogene. 2020 Jan; 39(2):469-485.
5. Wang YY, Weng XL, Wang LY, Hao MG, Li Y, Hou LD, Liang Y, Wu TQ, Yao MF, Lin GW, Jiang YW, Fu GH, Hou ZY*, Meng XJ*, Lu JS*, Wang JH*. HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk. Journal of Clinical Investigation. 2018 Dec 3; 128(12):5235-5250.
6. Bian XJ^#, Xiao YT^#, Wu TQ, Yao MF, Du LL, Ren SC*, Wang JH*. Microvesiclesand chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression. Molecular Cancer. 2019 Mar 30; 18(1):50.
7. Hao MG, Wang JL, Qin J, Ding YF, Sun XQ, Zu LD, Wang YY, Li Y, Chang K， Lin GW, Du JY, Korinek V, Ye DW, Wang JH^*. HIC1 loss promotes prostate cancer metastasis by triggering epithelial–mesenchymal transition. The Journal of Pathology. 2017 Aug; 242(4):409-420.
8. Zu LD, Xue YJ, Wang JL, Fu YJ, Wang XM, Xiao G, Hao MG, Sun XQ, Wang YY,  Fu GH, Wang JH^*. The feedback loop between miR-124 and TGF-β pathway plays a significant role on non-small cell lung cancer metastasis. Carcinogenesis. 2016 Mar; 37(3):333-343.
9. Cheng GC, Sun XQ, Wang JL, Xiao G, Wang XM, Fan XM, Zu LD, HaoMG, Qu Q, Mao Y, Xue YJ, Wang JH^*. HIC1 silencing in triple-negative breast cancer drives progression through misregulation of LCN2. Cancer Research. 2014 Feb 1; 74(3):862-72.
10. Zheng JH, Wang JL, Sun XQ, Hao MG，Ding T, Xiong D, Wang XM, Zhu Z, Xiao G, Cheng GC, Zhao MZ, Zhang J, Wang JH^* . HIC1 by epigenetic modification modulates prostate cancer progression. Clinical Cancer Research. 2013 Mar 15; 19(6):1400-10.