Xianghuo HE
Ph.D., Professor
E-mail: xhhe@fudan.edu.cn
 

Xianghuo He has received his B.S. and M.S. degrees from East China Normal University in 1995 and 1998 respectively, and obtained his Ph.D. degree from Shanghai Medical College, Fudan University in 2003. From 2003 through 2006, Dr. He began his research on cancer cell signaling as a Postdoctoral research fellow at Department of Molecular & Cellular Oncology, UT M.D. Anderson Cancer Center. In 2006, Dr. He was recruited to State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, and was appointed as the Principal Investigator (PI) of Section of Functional Genomics from April, 2006 to December, 2013. Since January 2014, Dr. He is appointed as PI and professor at Institutes of Biomedical Sciences and Shanghai Cancer Center, Shanghai Medical College, Fudan University.


Dr. He is currently engaged in his scientific research on the genetic and epigenetic regulation of cancer development, progression and metastasis of human liver cancer. Dr. He has published over 120 articles in Nature Cell Biology, Gastroenterology, Hepatology, Cell Research, Nature Communications, Nucleic Acids Research, Cancer Research, Clinical Cancer Research, etc. which are cited more than 10,000 times. H-index is 50 (all published papers please ref: ORCID:0000-0001-8872-668X; Web of Science ResearcherID:I-1497-2014).


Research Focus:

Mainly focus on: 1, non-coding RNAs; 2, RNA alternative splicing; 3, Transcriptional reprogramming and epigenetic regulation.


Selected Publications (* corresponding):

  1. Ding J#, Zhao J, Huan L, Liu Y, Qiao Y, Wang Z, Chen Z, Huang S, Zhao Y*, He X*. Inflammation-Induced Long Intergenic Noncoding RNA (LINC00665) Increases Malignancy Through Activating the Double-Stranded RNA-Activated Protein Kinase/Nuclear Factor Kappa B Pathway in Hepatocellular Carcinoma. Hepatology, 2020 Nov;72(5):1666-1681.
  2. Hu Z#, Dong L#, Li S, Li Z, Qiao Y, Li Y, Ding J, Chen Z, Wu Y, Wang Z, Huang S, Gao Q*, Zhao Y*, He X*. Splicing Regulator p54 nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma. Hepatology, 2020 Aug; 72(2):548-568.
  3. Li S#, Hu Z, Zhao Y, Huang S, He X*. Transcriptome-Wide Analysis Reveals the Landscape of Aberrant Alternative Splicing Events in Liver Cancer. Hepatology, 2019 Jan; 69(1):359-375.
  4. Li Z#, Zhang J#, Liu X#, Li S, Wang Q, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q*, Zhao Y*, He X*. The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma. Nat Commun, 2018 Apr 20; 9(1):1572.
  5. Qiu Z#, Guo W#, Wang Q#, Chen Z, Huang S, Zhao F, Yao M, Zhao Y*, He X.* MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells. Gastroenterology, 2015 Nov; 49(6):1587-1598.e11.
  6. Guo W#, Qiu Z#, Wang Z#, Wang Q, Tan N, Chen T, Chen Z, Huang S, Gu J, Li J, Yao M, Zhao Y*, He X.* MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. Hepatology, 2015 Oct; 62(4):1132-44.
  7. Jia D#, Jing Y, Zhang Z, Liu L, Ding J, Zhao F, Ge C, Wang Q, Chen T, Yao M, Li J, Gu J, He X.* Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma. Cell Res, 2014 Feb; 24(2):204-17.
  8. Ding J#, Huang S#, Wang Y, Tian Q, Zha R, Shi H, Wang Q, Ge C, Chen T, Zhao Y, Liang L, Li J, He X.* Genome-wide screening reveals that miR-195 targets the TNF-α/NF-κB pathway by down-regulating IκB kinase alpha and TAB3 in hepatocellular carcinoma. Hepatology, 2013 Aug; 58(2):654-66.
  9. Jia D#, Wei L, Guo W, Zha R, Bao M, Chen Z, Zhao Y, Ge C, Zhao F, Chen T, Yao M, Li J, Wang H, Gu J, He X.* Genome-wide copy number analyses identified novel cancer genes in hepatocellular carcinoma. Hepatology, 2011 Oct; 54(4): 1227-36.
  10. Ding J#, Huang S#, Wu S, Zhao Y, Liang L, Yan M, Ge C, Yao J, Chen T, Wan D, Wang H, Gu J, Yao M, Li J, Tu H, He X.* Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nat Cell Biol, 2010 Apr; 12(4):390-9.