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1999年毕业于上海医科大学获得博士学位。2004年在美国M.D. Anderson肿瘤中心学习。现任复旦大学附属肿瘤医院微创治疗中心/中西医结合科主任、美国M.D. Anderson肿瘤中心兼职教授、中国临床肿瘤学会肿瘤消融治疗专家委员会主任委员、上海市抗癌协会肿瘤微创治疗委员会主任委员、中国医师协会微无创医学专业委员会副主任委员、国际肝胆胰协会中国分会介入治疗专业委员会副主任委员、上海市中西医结合学会胰腺病专业委员会副主任委员、上海中西医结合学会肝病专业委员会副主任委员、上海市抗癌协会理事、亚洲肿瘤消融学会理事、国际微无创医学协会理事、《JCRT》副主编、《肿瘤》杂志编委等职。
2011年获得上海市科技进步二等奖和教育部科技进步二等奖;2012年获得中西医结合学会一等奖;2012年获得明治生命科学奖;2016年获得上海市科技进步一等奖。入选上海市“领军人才计划”。作为项目负责人主持美国NIH/NCI-R01、U19项目、国家自然科学基金重点项目、上海市科委重点项目等10余项,资助金额超过2000万。先后在Gastroenterology、Oncogene、Mol Oncol、Brit J Cancer、Eur J Cancer、Autophage等发表论文163篇,他引超过2200次,H-index:27。批准专利2项。主持临床研究40余项。
研究领域:
肝、胆、胰腺肿瘤的耐药机制及微创治疗对策研究
1. Na+K+ATP酶在肝癌的功能研究及药物筛选;
2. 炎性微环境与肝胰腺肿瘤肿瘤的耐药机制;
3. 肿瘤微创治疗的临床研究。
代表性论著:
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Yang
LN, Ning ZY, Wang L, Yan X, Meng Z*. HSF2
regulates aerobic glycolysis by suppression of FBP1 in hepatocellular
carcinoma. Am J Cancer Res, 2019 Aug 1; 9(8):1607-1621.
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Shi
W, Zhang C, Ning Z, Hua Y, Li Y, Chen L, Liu L, Chen Z, Meng Z*. Long
non-coding RNA LINC00346 promotes pancreatic cancer growth and gemcitabine
resistance by sponging miR-188-3p to derepress BRD4 expression. J Exp Clin Cancer Res. 2019 Feb 6; 38(1):60.
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Ning
Z, Xie J, Chen Q, Zhang C, Xu L, Song L, Meng
Z*. HIFU
is safe, effective, and feasible in pancreatic cancer patients: a monocentric
retrospective study among 523 patients. Onco Targets Ther,
2019 Feb 1; 12:1021-1029.
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Zhuang
L, Yan X, Meng Z. Second primary malignancy in patients with
cholangiocarcinoma: a population-based study. Cancer
Manag Res, 2019 Mar 1; 11:1969-1983.
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Jing
X, Yan Z X, Ming L L, Meng Z*. Solute carrier transporters:
potential targets for digestive system neoplasms. Cancer Management
and Research, 2018; 10:153-166.
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Wang
H, Zhang C, Chi H, Meng Z*. Synergistic anti-hepatoma effect of bufalin combined
with sorafenib via mediating the tumor vascular
microenvironment by targeting mTOR/VEGF signaling. Int J Oncol, 2018 Apr 2.
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Wang,
Q., Qu, C., Xie, F., Chen, L., Liu, L., Liang, X., Meng, Z*. Curcumin
suppresses epithelial-to-mesenchymal transition and metastasis of pancreatic
cancer cells by inhibiting cancer-associated fibroblasts. American Journal of Cancer Research,
2017; 7(1):125-133.
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Milbury,
K, Kavanagh, A, Meng, Z*, Chen, Z, Chandwani, KD, Garcia,
K, Perkins, GH, McQuade, J, Raghuram, NV, Nagarathna, R, Liao, Z, Nagendra, HR,
Chen, J, Guo, X, Liu, L, Arun, B & Cohen, L. Depressive symptoms and positive affect in Chinese and
United States breast cancer survivors: a cross-cultural comparison. Supportive
Care in Cancer, 2017 Jul; 25(7):2103-2109.
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Xie,
J, Chen, LH, Ning, ZY, Zhang, CY, Chen, H, Chen, Z, Meng, Z*, Zhu, XY. Effect of transcutaneous electrical acupoint
stimulation combined with palonosetron on chemotherapy-induced nausea and
vomiting: A single-blind, randomized, controlled trial. Chinese Journal of Cancer,
2017 Jan 10; 36(1):6.
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Zhang,
C., Wang, H., Ning, Z., Xu, L., Zhuang, L., Wang, P., & Meng, Z. Q*. Hyperfibrinogen is associated with the systemic
inflammatory response and predicts poor prognosis in intrahepatic
cholangiocarcinoma. International Journal of Clinical and Experimental Medicine,
2017; 10(3): 5670-5677.
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Liu,
F, Meng, Z*, Shao, G, Wang, J, Wang, Z, Yang, J, Yip, CSM & He, D.
Patterns of sorafenib and TACE treatment of unresectable hepatocellular
carcinoma in a Chinese population: subgroup analysis of the GIDEON study. Molecular
Biology Reports, 2017; 44(1):149-158.
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Zhang
C, Wang H, Ning Z, Xu L, Zhuang L, Wang P, Meng
Z*. Serum liver enzymes serve as prognostic factors
in patients with intrahepatic cholangiocarcinoma. Onco Targets Ther,
2017 Mar 6; 10: 1441-1449.
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Ning,
ZY, Cheng, CS, Xie, J, Chen, QW, Xu, LT, Zhuang, L, Zhang, CY, Song, LB, Shi,
WD, Zhu, XY, Wang, P, Wang, K, Meng, ZQ*. A retrospective analysis of survival
factors of High Intensity Focused Ultrasound (HIFU) treatment for unresectable
pancreatic cancer. Discovery Medicine, 2016 Jun; 21(118):435-45.
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Wang,
H, Ning, Z, Li, Y, Zhu, X, Meng Z*. Bufalin suppresses cancer
stem-like cells in gemcitabine-resistant pancreatic cancer cells via hedgehog
signaling. Molecular Medicine Reports, 2016; 14(3):1907-1914
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Wang
H, Zhang C, Ning Z, Xu L, Zhu X, Meng Z*. Bufalin enhances
anti-angiogenic effect of sorafenib via AKT/VEGF signaling. Int J
Oncol, 2016 Mar; 48(3):1229-41.
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Zhuang
L, Xu L, Wang P, Jiang Y, Yong P, Zhang C, Zhang H, Meng Z*, Yang P.
Na+/K+-ATPase 1 subunit, a novel therapeutic target for hepatocellular
carcinoma. Oncotarget, 2015; 6(29):28183-93.
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Shen
Y, Pan Y, Xu L, Chen L, Liu L, Chen H, Chen Z, Meng Z*. Identifying
microRNA-mRNA regulatory network in gemcitabine-resistant cells derived from
human pancreatic cancer cells. Tumour Biol, 2015;
36(6):4525-34.
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Wang
SY, Feng LY, Meng ZQ*. Bicluster and pathway enrichment analysis
related to tumor progression of hepatocellular carcinoma. Eur Rev
Med Pharmacol Sci, 2015; 19(7):1191-7.
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Zhuang
LP, Meng ZQ*. Serum miR-224 reflects stage of hepatocellular
carcinoma and predicts survival. Biomed Res Int, 2015;
2015:731781.
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Zhuang
L, Xu L, Wang P, Meng Z*. Serum miR-128-2 serves as a prognostic
marker for patients with hepatocellular carcinoma. PLoS One,
2015 Feb 2; 10(2):e0117274.
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Wang
P, Chen L, Zhang J, Chen H, Fan J, Wang K, Luo J, Chen Z, Meng ZQ*.
Methylation-mediated silencing of the miR-124 genes facilitates pancreatic
cancer progression and metastasis by targeting Rac1. Oncogene,
2014; 33(4):514-24.
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Shi
W, Yin J, Chen Z, Chen H, Liu L, Meng Z*. Cyr61 promotes growth of
pancreatic carcinoma via nuclear exclusion of p27. Tumour Biol,
2014 Nov; 35(11):11147-51.
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Wang
H, Xu L, Zhu X, Wang P, Chi H, Meng ZQ*. Activation of
phosphatidylinositol 3-kinase/Akt signaling mediates sorafenib-induced invasion
and metastasis in hepatocellular carcinoma. Oncol Rep,
2014; 32(4):1465-72.
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Chen
QW, Cheng CS, Chen H, Ning ZY, Tang SF, Zhang X, Zhu XY, Vargulick S, Shen YH,
Hua YQ, Xie J, Shi WD, Gao HF, Xu LT, Feng LY, Lin JH, Chen Z, Liu LM, Ping
B, Meng ZQ*. Effectiveness and complications of ultrasound guided
fine needle aspiration for primary liver cancer in a Chinese population with
serum α-fetoprotein levels ≤200 ng/ml--a study based on 4,312 patients. PLoS
One, 2014; 9(8):e101536.
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Chen
QW, Chen H, Cheng JS, Meng ZQ*. MDM2 SNP309T>G polymorphism and
hepatocellular carcinoma risk: a meta-analysis. Tumour Biol,
2014; 35(5):4147-51.
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Chen
QW, Zhu XY1, Li YY2, Meng ZQ*. Epigenetic regulation and
cancer (review). Oncol Rep, 2014; 31(2):523-32.
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Wang
P, Zhang J, Zhang L, Zhu Z, Fan J, Chen L, Zhuang L, Luo J, Chen H, Liu L, Chen
Z, Meng Z*. MicroRNA 23b regulates autophagy associated with
radioresistance of pancreatic cancer cells. Gastroenterology,
2013; 145(5):1133-1143.e12.
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Wang
P, Zhuang L, Zhang J, Fan J, Luo J, Chen H, Wang K, Liu L, Chen Z, Meng
Z*. The serum miR-21 level serves as a predictor for the chemosensitivity
of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by
targeting FasL. Mol Oncol, 2013; 7(3):334-45.
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Wang
P, Zhang L, Chen Z, Meng Z*. MicroRNA targets autophagy in
pancreatic cancer cells during cancer therapy. Autophagy,
2013; 9(12):2171-2.
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Chen
Q, Zhu X, Chen Q, Wang K, Meng ZQ*. Unresectable giant pancreatic
neuroendocrine tumor effectively treated by high-intensity focused ultrasound:
a case report and review of the literature. Pancreatology,
2013; 13(6):634-8.
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Xie
J, Chen Z, Liu L, Li P, Zhu X, Gao H, Meng Z*. shRNA-mediated
Slc38a1 silencing inhibits migration, but not invasiveness of human pancreatic
cancer cells. Chin J Cancer Res, 2013; 25(5):514-9.
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Zhuang
L, Zeng X, Yang Z, Meng Z*. Effect and safety of interferon for
hepatocellular carcinoma: a systematic review and meta-analysis. PLoS
One, 2013; 8(9):e61361.
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Wang
S, Zhuang L, Meng Z*. Hepatocellular Carcinoma More Than 3 cm in
Diameter: A Systematic Review of Transcatheter Arterial Chemoembolization Plus
Percutaneous Ethanol Injection versus Transcatheter Arterial Chemoembolization
Alone. ISRN Gastroenterol, 2013; 2013:526024.
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Wang
K, Zhu H, Meng Z*, Chen Z, Lin J, Shen Y, Gao H. Safety evaluation
of high-intensity focused ultrasound in patients with pancreatic cancer. Onkologie,
2013; 36(3):88-92.
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Zhuang
L, Yang Z, Zeng X, Zhua X, Chen Z, Liu L, Meng Z*. The preventive
and therapeutic effect of acupuncture for radiation-induced xerostomia in
patients with head and neck cancer: a systematic review. Integr
Cancer Ther, 2013; 12(3):197-205.
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Gao
HF, Wang K, Meng ZQ*, Chen Z, Lin JH, Zhou ZH, Wang P, Shi WD,
Sheng YH. High intensity focused ultrasound treatment for patients with local
advanced pancreatic cancer. Hepatogastroenterology,
2013; 60(128):1906-10.
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Meng
Z*, Garrett CR,Shen Y,Liu L, Yang P, Huo Y, Zhao Q, Spelman AR, Ng CS,
Chang DZ, Cohen L . Prospective randomised evaluation of traditional Chinese
medicine combined with chemotherapy: a randomised phase II study of wild toad
extract plus gemcitabine in patients with advanced pancreatic
adenocarcinomas. Br J Cancer, 2012; 107(3):411-6.
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Meng
Z*, Kay Garcia M, Hu C,
Chiang J, Chambers M, Rosenthal DI, Peng H, Wu C, Zhao Q, Zhao G, Liu L,
Spelman A, Lynn Palmer J, Wei Q, Cohen L. Sham-controlled, randomised,
feasibility trial of acupuncture for prevention of radiation-induced xerostomia
among patients with nasopharyngeal carcinoma. Eur J Cancer,
2012; 48(11):1692-9.
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Meng
Z*, Garcia MK, Hu C,
Chiang J, Chambers M, Rosenthal DI, Peng H, Zhang Y, Zhao Q, Zhao G, Liu L,
Spelman A, Palmer JL, Wei Q, Cohen L. Randomized controlled trial of
acupuncture for prevention of radiation-induced xerostomia among patients with
nasopharyngeal carcinoma. Cancer, 2012;
118(13):3337-44.
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Gao
Y, Li HX, Xu LT, Wang P, Xu LY, Cohen L, Yang
PY, Gu K, Meng ZQ*. Bufalin enhances the anti-proliferative
effect of sorafenib on human hepatocellular carcinoma cells through
downregulation of ERK. Mol Biol Rep, 2012;
39(2):1683-9.
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