临床PI
蔡三军 教授
教授,博士生导师
E-mail: caisanjuncsj@163.com
 

  复旦大学附属肿瘤医院大肠癌多学科协作组首席专家、复旦大学大肠癌诊治中心主任、上海市抗癌协会大肠癌专业委员会主任委员、中国抗癌协会大肠癌专业委员会前主任委员、美国临床肿瘤指南(NCCN)中国版专家委员会委员、NCCN大肠癌临床实践指南(中国版)外科执笔人、主要从事结直肠癌基础和临床研究,尤其擅长于大肠癌的手术治疗,是中国著名的大肠癌专家。 

      主编《结直肠肛门肿瘤》(北京大学出版社,2005)及《循证结直肠肛管肿瘤学》(上海科学技术出版社2015)。主持国家自然科学基金课题、国家863及973、复旦211等重大科研课题,累计经费4200余万。

      近5年发表医学论文90余篇,其中SCI 70余篇。2012获得上海市科学技术及教育部科技进步二等奖,2018获上海预防医学会科学技术二等奖,2019获第三届国之名医盛典-卓越建树奖和科教资讯一等奖。


研究领域:

1、大肠癌、胃癌、软组织腹膜后肿瘤、恶性黑色素瘤等腹部肿瘤的手术治疗;
2、局部晚期大肠癌及复发转移性大肠癌的综合治疗;
3、大肠癌的早期筛查、分子生物标志物及复发转移机制研究;
4、大肠癌类器官平台建设与转化治疗。



研究团队:

 自2005年来担任复旦大学大肠癌中心主委、肿瘤医院大肠癌多学科协作组首席科学家,对大肠癌诊治方面的各种治疗方式、综合治疗、个体化治疗有较深的理解,形成了国内最好的大肠癌MDT队伍,团队包括大肠外科、放疗科、肿瘤内科、病理科、放射诊断、内镜科、肝外科、介入科及中医科,积极推动了国内大肠癌的规范性多学科综合治疗的发展。




代表性论著:

  1. Li Q#, Wei P#, Wu J, Zhang M, Li G, Li Y, Xu Y, Li X, Xie D, Cai S*, Xie K*, Li D*. The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect. Oncogene, 2019Jan; 38(4):483-496.
  2. Hu X#, Li YQ, Li QG, Ma YL, Peng JJ, Cai SJ*. Adjuvant Chemotherapy Seemed Not to Have Survival Benefit in Rectal Cancer Patients with ypTis-2N0 After Preoperative Radiotherapy and Surgery from a Population-Based Propensity Score Analysis. Oncologist, 2019 Jun; 24(6):803-811.
  3. Li Y#, Wang R#, Huang D#, Ma X, Mo S, Guo Q, Fu G, Li Y, Xu X, Hu X, Zhou Y, Deng Y, Zhang L, Chen H, Gao J, Zhang Z, Cai S*, Hua G*, Peng J*. A novel human colon signet-ring cell carcinoma organoid line: establishment, characterization and application. Carcinogenesis, 2019 Nov 19.
  4. Zhang S#, Yang Y, Weng W, Guo B, Cai G, Ma Y, Cai S*. Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer. J Exp Clin Cancer Res, 2019 Jan 10; 38(1):14.
  5. Hu X#, Li YQ, Ma XJ, Zhang L, Cai SJ*, Peng JJ*. A Risk Signature With Inflammatory and T Immune Cells Infiltration in Colorectal Cancer Predicting Distant Metastases and Efficiency of Chemotherapy. Front Oncol, 2019 Aug 13; 9:704.
  6. Feng Y#, Li Y, Huang D, Cai S*, Peng J*. HER2 as a potential biomarker guiding adjuvant chemotherapy in stage II colorectal cancer. Eur J Surg Oncol, 2019 Feb; 45(2):167-173.
  7. Hu X#, Li YQ, Li QG, Ma YL, Peng JJ, Cai SJ*. Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway. J Exp Clin Cancer Res, 2018 Mar 2; 37(1):41.
  8. Li Q#, Li Y#, Li J, Ma Y, Dai W, Mo S, Xu Y, Li X*, Cai S*. FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1alpha/CEACAM5 functional axis. Int J Biol Sci,  2018 May 12; 14(7):726-735.
  9. Hu X#, Li YQ, Li QG, Ma YL, Peng JJ*, Cai SJ*. Baseline Peripheral Blood Leukocytosis Is Negatively Correlated With T-Cell Infiltration Predicting Worse Outcome in Colorectal Cancers. Front Immunol, 2018 Oct 12; 9:2354.
  10. Hu X#, Li YQ, Li QG, Ma YL, Peng JJ*, Cai SJ*. ITGAE Defines CD8+ Tumor-Infiltrating Lymphocytes Predicting a better Prognostic Survival in Colorectal Cancer. EBioMedicine, 2018 Sep; 35:178-188.
  11. Hu X#, Li YQ, Li QG, Ma YL, Peng JJ, Cai SJ*. Osteoglycin-induced VEGF Inhibition Enhances T Lymphocytes Infiltrating in Colorectal Cancer. EBioMedicine, 2018 Aug; 34:35-45.
  12. Li Q#, Dai W#, Jia H#, Li Y, Xu Y, Li X*, Cai G*, Cai S*. Prognostic Impact of Hypochloremia in Patients With Stage I to III Colorectal Cancer After Radical Resection. Dis Colon Rectum, 2018 Nov; 61(11):1273-1280.
  13. Li Y#, Feng Y#, Dai W, Li Q, Cai S*, Peng J*. Prognostic Effect of Tumor Sidedness in Colorectal Cancer: A SEER-Based Analysis. Clin Colorectal Cancer, 2019 Mar; 18(1):e104-e116.
  14. Yang Y#, Weng W#, Peng J#, Hong L#, Yang L, Toiyama Y, Gao R, Liu M, Yin M, Pan C, Li H, Guo B, Zhu Q, Wei Q, Moyer MP, Wang P, Cai S*, Goel A*, Qin H*, Ma Y*. Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-kappaB, and Up-regulating Expression of MicroRNA-21. Gastroenterology, 2017 Mar; 152(4):851-866.
  15. Shi D#, Liang L#, Zheng H, Cai G, Li X, Xu Y*, Cai S*. Silencing of long non-coding RNA SBDSP1 suppresses tumor growth and invasion in colorectal cancer. Biomed Pharmacother, 2017 Jan; 85:355-361.
  16. Li Y#, Liang L#, Dai W, Cai G, Xu Y, Li X, Li Q*, Cai S*. Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer. Mol Cancer, 2016 Aug 24; 15(1):55.
  17. Wang S#, Zhang Q#, Yang P, Yu X, Huang LY, Shen S*, Cai S*. Manganese Oxide-Coated Carbon Nanotubes As Dual-Modality Lymph Mapping Agents for Photothermal Therapy of Tumor Metastasis. ACS Applied Materials & Interfaces, 2016 Feb 17; 8(6):3736-43.
  18. Li Y#, Jia H#, Yu W, Xu Y, Li X, Li Q*, Cai S*. Nomograms for predicting prognostic value of inflammatory biomarkers in colorectal cancer patients after radical resection. Int J Cancer, 2016 Jul 1; 139(1):220-31.
  19. Li Q#, Wei P#, Huang B#, Xu Y, Li X, Li Y, Cai S*, Li D*. MAEL expression links epithelial-mesenchymal transition and stem cell properties in colorectal cancer. Int J Cancer, 2016; 139:2502-11.
  20. Li Q#, Qin Y#, Wei P, Lian P, Li Y, Xu Y, Li X, Li D*, Cai S*. Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma. Mol Cancer Res, 2016 Sep; 14(9):830-40.
  21. Li X#, Liang L#, Huang L, Ma X, Li D, Cai S*. High expression of protein phosphatase 4 is associated with the aggressive malignant behavior of colorectal carcinoma. Mol Cancer, 2015 Apr 28; 14:95.
  22. Li Q#, Meng X#, Liang L, Xu Y, Cai G*, Cai S*. High preoperative serum globulin in rectal cancer treated with neoadjunctive chemoradiation therapy is a risk factor for poor outcome. Am J Cancer Res, 2015 Aug 15; 5(9):2856-64.
  23. Li Q#, Wu J#, Wei P, Xu Y, Zhuo C, Wang Y, Li D, Cai S*. Overexpression of forkhead Box C2 promotes tumor metastasis and indicates poor prognosis in colon cancer via regulating epithelial-mesenchymal transition. Am J Cancer Res, 2015 May 15; 5(6):2022-34.
  24. Zhuo C#, Li Z, Xu Y, Wang Y, Li Q, Peng J, Zheng H, Wu P, Li B*, Cai S*. Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival. Molecular Cancer, 2014 Jun 18; 13:153.
  25. Xu Y#, Xu Q#, Yang L, Ye X, Liu F, Wu F, Ni S, Tan C, Cai G, Meng X, Cai S*, Du X*. Identification and validation of a blood-based 18-gene expression signature in colorectal cancer. Clin Cancer Res, 2013 Jun 1; 19(11):3039-49.
  26. Peng J#, Chen W, Venook AP, Sheng W, Xu Y, Guan Z, Cai G, Cai S*. Long-term outcome of early-stage rectal cancer undergoing standard resection and local excision. Clin Colorectal Cancer , 2011 Mar 1; 10(1):37-41.
 
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