专职PI
杨恭 研究员
研究员，博士生导师
E-mail: yanggong@fudan.edu.cn
 

　　2001年毕业于中国科学院微生物研究所，获得博士学位。2001年至2005年先后在美国休斯敦霍华德·休斯医学研究所、美国M.D. Anderson肿瘤中心从事博士后研究工作。2005年任美国德克萨斯大学M.D. Anderson癌症研究中心病理系讲师，并于2008年升职为美国德克萨斯大学M.D. Anderson癌症研究中心病理系助理教授。2010年回国工作，担任复旦大学附属肿瘤医院研究所研究员，博士生导师，实验研究中心/研究所副主任。2012年6-8月作为客座教授在日本金沢大学癌症研究所工作。2013年至今，任复旦大学附属肿瘤医院研究所研究员，博士生导师，妇科肿瘤/肿瘤化疗研究课题组长/PI；复旦大学附属上海市第五人民医院特聘教授，博士生导师，中心实验室常务副主任,组织样本库/慢性病平台负责人。

      杨恭教授目前在JNCI、PNAS、Clin Cancer Res、JBC、Cancer Res、Theranotics、Molecular Therapy、Oncogene、Cancer letter、European Journal of Cancer、International Journal of Cancer等国际知名杂志上发表SCI论文近70余篇。主持国家自然科学基金/重大研发计划5项，教育部博士点基金博导类1项；上海市浦江人才计划1项；上海市卫生局局级基金2项；参与科技部重大研发计划（子课题）精准医学项目 1项，重大慢性非传染性疾病项目（子课题）1项。


研究领域：

　　1. 肿瘤微环境IL-8和ECM1促进肿瘤转移复发、干细胞分化和化疗抵抗的机制；
　　2. 细胞永生化与转化动物模型构建及分析；
　　3. 细胞衰老与恶性转化；
　　4. RAS/P53相关基因突变与细胞凋亡、衰老以及EMT、自噬的关系；
　　5. 肿瘤靶向药物的筛选与开发；
　　6. DNA损伤修复与肿瘤放化疗抵抗及其与肿瘤干细胞调控的机制。


研究团队：

　　现有研究助理1名，技术员1名，研究生7名。


代表性论著：

  1. Yang Shao, Xiaomin Liu, Jiao Meng, Xiaofei Zhang, Zhongliang Ma, Gong Yang*. MicroRNA-1251-5p Promotes Carcinogenesis and Autophagy via Targeting the Tumor Suppressor TBCC in Ovarian Cancer Cells. Molecular Therapy, 2019 Sep; 27(9):1653-64.
  2. Xiaofei Zhang, Zihao Qi, Huijing Yin, Gong Yang*. Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy. Theranostics，2019; 9(4):1096-114.
  3. Fan Liang, Chunxia Ren, Jingshu Wang, Shuoer Wang, Lina Yang, Xianghui Han, Yaping Chen, Guoqing Tong, Gong Yang*. The crosstalk between STAT3 and p53/RAS signaling controls cancer cell metastasis and cisplatin resistance via the Slug/MAPK/PI3K/AKT-mediated regulation of EMT and autophagy. Oncogenesis, 2019; 8(10):59.
  4. Jingshu Wang, Lina Yang, Fan Liang, Yaping Chen, Gong Yang*. ITGAX stimulates cancer angiogenesis through PI3K/Akt signaling–mediated VEGFR2/VEGF‐A overexpression in blood vessel endothelial cells. J Cell Biochem, 2019; 120(2):1807-1818.
  5. Bin Chang, Jiao Meng, Huimin Zhu, Xiang Du, Lili Sun, Lei Wang, Shugang Li, Gong Yang*. Overexpression of the recently identified oncogene REDD1 correlates with tumor progression and is an independent unfavorable prognostic factor for ovarian carcinoma. Diagnostic Pathology, 2018 Nov 14; 13(1):87.
  6. Han Xu, Fengjuan Lin, Ziliang Wang, Lina Yang, Jiao Meng, Zhouluo Ou, Zhimin Shao, Genhong Di, Gong Yang*. CXCR2 promotes breast cancer metastasis and chemoresistance via suppression of AKT1 and activation of COX2. Cancer Letters, 2018; 412:69-80.
  7. Zhang X, Wang S, Zhao S, Sun Y, Yang G*. Postoperative chemotherapy had no prognostic effect on early-staged young ovarian cancer with unilateral resection. Cancer Med, 2018 Nov; 7(11):5488-5496.
  8. Shao Y, Li H, Du R, Meng J, Yang G*. Involvement of non-coding RNAs in chemotherapy resistance of ovarian cancer. J Cancer, 2018 Apr 30; 9(11):1966-1972.
  9. Chang B, Meng J, Zhu H, Du X, Sun L, Wang L, Li S, Yang G*.Overexpression of the recently identified oncogene REDD1 correlates with tumor progression and is an independent unfavorable prognostic factor for ovarian carcinoma. Diagnostic Pathology, 2018 Nov 14;13(1):87. doi: 10.1186/s13000-018-0754-4.
  10. Xiang L, Jiang W, Ye S, He T, Pei X, Li J, Chan DW, Ngan HYS, Li F, Tao P, Shen X, Zhou X, Wu X, Yang G*, Yang H. ERBB2 mutation: A promising target in non-squamous cervical cancer. Gynecol Oncol, 2018 Feb;148(2):311-316.
  11. Shuqing Li, Lina Yang, Jingshu Wang, Fan Liang, Bin Chang, Huafen Gu, Honglin Wang, Yang Gong*, Yaping Chen. Analysis of the chemotherapeutic effects of a propadiene compound on malignant ovarian cancer cells. Oncotarget, 2017; 7(35):57145-57159.
  12. Zhang X, Cheng Q, Yin H and Yang G*. Regulation of autophagy and EMT by the interplay between p53 and RAS during cancer progression. Int J Oncol, 2017; 51:18-24.
  13. Shuwen Yang, Qinghai Ji, Bin Chang, Yan Wang, Yongxue Zhu, Duanshu Li, Caiping Huang, Yulong Wang, Guohua Sun, Ling Zhang, Qing Guan, Jun Xiang, Wenjun Wei, Zhongwu Lu, Tian Liao, Jiao Meng, Ziliang Wang, Ben Ma, Li Zhou, Yu Wang, Gong Yang*. STC2 promotes head and neck squamous cell carcinoma metastasis through modulating the PI3K/AKT/Snail signaling. Oncotarget, 2017; 8(4):5976-5991.
  14. Lu L, Wang J, Wu Y, Wang P, Yang G*. Rap1A promotes ovarian cancer metastasis via activation of ERK/p38 and notch signaling. Cancer Medicine, 2016; 5(12):3544–3554.
  15. Xiao X, Yang G#, Bai P, Gui S, Nyuyen TM, Mercado-Uribe I, Yang M, Zou J, Li Q, Xiao J, Chang B, Liu G, Wang H, Liu J. Inhibition of nuclear factor-kappa B enhances the tumor growth of ovarian cancer cell line derived from a low-grade papillary serous carcinoma in p53-independent pathway. BMC Cancer, 2016 Aug 2;16:582.
  16. Yin S, Wang P, Yang L, Liu Y, Wang Y, Liu M, Qi Z, Meng J, Shi T, Yang G*, Zang R. Wip1 suppresses ovarian cancer metastasis through the ATM/AKT/Snail mediated signaling. Oncotarget, 2016; 7(20):29359-29370.
  17. Yin K, Yin W, Wang Y, Zhou L, Liu Y, Yang G*, Wang J, Lu J. MiR-206 suppresses epithelial mesenchymal transition by targeting TGF-β signaling in estrogen receptor positive breast cancer cells. Oncotarget, 2016; 7(17):24537-24548.
  18. Li Y, Zhou J, Wu Y, Lu T, Yuan M, Cui Y, Zhou Y, Yang G*, Hong Y. Association of osteoporosis with geneticvariants of circadiangenes in Chinesegeriatrics. OsteoporosInt, 2016 Apr; 27(4):1485-92.
  19. Zhou J, Li Y, Yang L, Wu Y, Zhou Y, Cui Y, Yang G*, Hong Y. Stanniocalcin 2 improves osteoblast differentiation via phosphorylation of ERK. Mol Med Rep, 2016 Dec;14(6):5653-5659.
  20. Wu Y, Zhou J, Li Y, Zhou Y, Cui Y, Yang G*, Hong Y. Rap1A Regulates Osteoblastic Differentiation via the ERK and p38 Mediated Signaling. PLoS One, 2015 Nov 24; 10(11):e0143777.
  21. Liu M, Qi Z, Liu B, Ren Y, Li H, Yang G*, Zhang Q. RY-2f, an isoflavone analog, overcomes cisplatin resistance to inhibit ovarian tumorigenesis via targeting the PI3K/AKT/mTOR signaling pathway. Oncotarget, 2015 Sep 22; 6(28): 25281-25294.
  22. Xiang L, Jiang W, Li J, Shen X, Yang W, Yang G*, Wu X, Yang H. PIK3CA mutation analysis in Chinese patients with surgically resected cervical cancer. Sci Rep, 2015 Sep 11; 5:14035.
  23. Sun JM, Yang LN, Xu H, Chang B, Wang HY, Yang G*. Inhibition of Aurora A promotes chemosensitivity via inducing cell cycle arrest and apoptosis in cervical cancer cells. Am J Cancer Res, 2015 Feb 15; 5(3):1133-1145.
  24. Qiu JJ, Wang Y, Ding JX, Jin HY, Yang G, Hua KQ. The long non-coding RNA HOTAIR promotes the proliferation of serous ovarian cancer cells through the regulation of cell cycle arrest and apoptosis. Exp Cell Res, 2015 May 1; 333(2):238-48.
  25. Hou J, Wang Z, Xu H, Yang L, Yu X, Yang Z, Deng Y, Meng J, Feng Y, Guo X, Yang G.* Stanniocalicin 2 Suppresses Breast Cancer Cell Migration and Invasion via the PKC/ Claudin-1-Mediated Signaling. PLoS One, 2015 Apr 1; 10(4):e0122179.
  26. Yang L, Shi T, Liu F, Ren C, Wang Z, Li Y, Tu X, Yang G*, Cheng X. REV3L, a promising target in regulating the chemosensitivity of cervical cancer cells. PLoS One, 2015 Mar 17; 10(3):e0120334.
  27. Wang Z, Liu Y, Lu L, Yang L, Yin S, Wang Y, Qi Z, Meng J, Zang R, Yang G*. Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis. Oncotarget, 2015 Mar 30; 6(9): 6670-83.
  28. Yang L, Zhou Y, Wu Y, Cui Y, Yang G*, Hong Y. p53 deficiency and KRAS mutation synergistically activate NF-kB to promote chemoresistance and tumorigenesis via dysregulation of cell cycle and suppression of apoptosis in lung cancer cells. Cancer Lett, 2015 Feb 28; 357(2):520-6.
  29. Qi Z, Liu M, Liu Y, Zhang M, Yang G*. Tetramethoxychalcone, a chalcone derivative, suppresses proliferation, blocks cell cycle progression, and induces apoptosis of human ovarian cancer cells. Plos One, 2014 Sep 2; 9(9):e106206.
  30. Wang Z, Liu Y, Yang L, Yin S, Zang R, Yang G*. The polymorphism interleukin-8 -251A/T is associated with a significantly increased risk of cancers from a meta-analysis. TumourBiol, 2014 Jul; 35(7):7115-23.
  31. Qian Y, Wang Y, Ji Q, Yang G*. The chemokine receptor- CXCR2 plays a critical role in the invasion and metastasis of oral squamous cell carcinoma in vitro and in vivo. J Oral Pathol Med, 2014 Oct; 43(9):658-66.
  32. Hou J, Wang Z, Yang L, Guo X, Yang G*. The function of EMSY in cancer development. Tumour Biol, 2014 Jun; 35(6):5061-6.
  33. Wang Y, Wang Z, Qi Z, Yin S, Zhang N, Liu Y, Liu M, Meng J, Zang R, Zhang Z, Yang G*. The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. Mol Cancer, 2014 Apr 28; 13:94.
  34. Sun H, Wang Y, Wang Z, Meng J, Qi Z, Yang G*. Aurora-A controls cancer cell radio- and chemoresistance via ATM/Chk2-mediated DNA repair networks. BiochimBiophysActa (Molecular Cell Research), 2014 May; 1843(5):934-44.
  35. Wang Y, Sun H, Wang Z, Liu M, Qi Z, Meng J, Sun J, Yang G*. Aurora-A: a potential DNA repair modulator. TumourBiol, 2014 Apr; 35(4):2831-6.
  36. Chen Y, Ke G, Han D, Liang S, Yang G, Wu X. MicroRNA-181a enhances the chemoresistance of human cervical squamous cell carcinoma to cisplatin by targeting PRKCD. Exp Cell Res, 2014 Jan 1; 320(1):12-20.
  37. Wang Z, Hou J, Lu L, Qi Z, Sun J, Gao W, Meng J, Wang Y, Sun H, Gu H, Xin Y, Guo X, Yang G*. Small ribosomal protein subunit S7 suppresses ovarian tumorigenesis through regulation of the PI3K/AKT and MAPK pathways. PLoS One, 2013 Nov 11; 8(11):e79117.
  38. Ren C, Cheng X, Lu B, Yang G*. Activation of interleukin-6/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironment. Eur J Cancer, 2013 Dec; 49(18):3889-99.
  39. Lin F, Luo J, Gao W, Wu J, Shao Z, Wang Z, Meng J, Ou Z, Yang G*. COX-2 promotes breast cancer cell radioresistance via p38/MAPK-mediated cellular anti-apoptosis and invasiveness. TumourBiol, 2013 Oct; 34(5):2817-26.
  40. Yang G*#, Mercado-Uribe I, Multani AS, Sen S, Shih IM, Wong KK, Gershenson DM, Liu J. RAS Promotes Tumorigenesis through Genomic Instability Induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis. Int J Cancer, 2013 Jul 15; 133(2):275-285.
  41. Shi TY, Yang L, Yang G, Tu XY, Wu X, Cheng X, Wei Q. DNA polymerase ζ as a potential biomarker of chemoradiation resistance and poor prognosis for cervical cancer. Med Oncol, 2013 Jun; 30(2):500.
  42. Shi TY, Yang G, Tu XY, Yang JM, Qian J, Wu XH, Zhou XY, Cheng X, Wei Q. RAD52 variants predict platinum resistance and prognosis of cervical cancer. PLoS One, 2012; 7(11):e50461.
  43. Guo X, Liu G, Schauer, IG, Yang G, Mercado-Uribe,I, Yang F, Zhang,S, He Y, Liu J, Over-expression of the beta subunit of human chorionic gonadotropin promotes the transformation of human ovarian epithelial cells and ovarian tumorigenesis. Am J Pathol, 2011 Sep; 179(3): 1385-93.
  44. Yang F, Guo X, Yang G, Rosen DG and Liu J. AURKA and BRCA2 expression highly correlate with prognosis of endometrioid ovarian carcinoma. Modern Pathology, 2011 Jun; 24(6):836-45.
  45. Yang G#, Xiao X, Rosen DG, Cheng X, Wu X, Chang B, Liu G, Xue F, Mercado- Uribe I, Chiao PJ, Du X, Liu J. The Biphasic Role of NF-{kappa}B in Tumor Progression and Chemoresistance of Ovarian Cancer. Clin Cancer Res, 2011 Apr 15; 17(8):2181-94.
  46. Cheng X, Yang G, Schmeler KM, Coleman RL, Tu X, Liu J, Kavanagh JJ. Recurrence patterns and prognosis of endometrial stromal sarcoma and the potential of tyrosine kinase-inhibiting therapy.GynecolOncol, 2011 May 1; 121(2):323-7.
  47. Yang G#, Rosen DG, Liu G, Yang F, Guo X, Xiao X, Xue F, Mercado-Uribe I, Huang J, Lin SH, Mills GB, Liu J.CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis. Clin Cancer Res, 2010 Aug 1; 16(15):3875-86.
  48. Liu G#, Yang G#, Chang B, Mercado-Uribe I, Huang M, Zheng J, Bast RC, Lin SH, Liu J. Stanniocalcin 1 and ovarian tumorigenesis. J Natl Cancer Inst, 2010 Jun 2; 102(11):812-27.
  49. Yang G#, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res, 2010 Jun 15; 16(12):3171-81.
  50. Zheng J, Mercado-Uribe I, Rosen DG, Chang B, Liu P, Yang G, Malpica A, Noara H, Auersperg N, Mills GB, Bast RC, Liu J. Induction of papillary carcinoma in human ovarian surface epithelial cells using combined genetic elements and peritoneal microenvironment. Cell Cycle, 2010 Jan 1; 9(1):140-6.
  51. Xiao X, Bai P, Bui Nguyen TM, Xiao J, Liu S, Yang G, Hu L, Chen X, Zhang X, Liu J, Wang H. The antitumoral effect of Paris Saponin I associated with the induction of apoptosis through the mitochondrial pathway. Mol Cancer Ther, 2009 May; 8(5):1179-88.
  52. Shan W, Yang G, Liu J. The inflammatory network: bridging senescent stroma and epithelial tumorigenesis. Front Biosci, 2009 Jan 1; 14:4044-57.
  53. Rosen DG, Yang G, Liu G, Mercado-Uribe I, Chang B, Xiao XS, Zheng J, Xue FX, Liu J. Ovarian cancer: pathology, biology, and disease models. Front Biosci, 2009 Jan 1; 14:2089-102.
  54. Chang B, Liu G, Yang G, Mercado-Uribe I, Huang M, Liu J. REDD1 is required for RAS-mediated transformation of human ovarian epithelial cells. Cell Cycle, 2009 Mar 1; 8(5):780-6.
  55. Wang D, Zhao Z, Caperell-Grant A, Yang G, Mok SC, Liu J, Bigsby RM, Xu Y. S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells. Mol Cancer Ther, 2008 Jul; 7 (7):1993-2002.
  56. Zhang Z, Singh M, Davidson S, Rosen DG, Yang G, Liu J. Activation of BTAK expression in primary ovarian surface epithelial cells of prophylactic ovaries. Mod Pathol, 2007 Oct; 20(10):1078-84.
  57. Yang G#, Rosen DG, Colacino JA, Mercado-Uribe I, Liu J.Disruption of the retinoblastoma pathway by small interfering RNA and ectopic expression of the catalytic subunit of telomerase lead to immortalization of human ovarian surface epithelial cells. Oncogene, 2007 Mar 1; 26(10): 1492-8.
  58. Young TW, Mei FC, Rosen DG, Yang G, Li N, Liu J, Cheng X. Up-regulation of Tumor Susceptibility Gene 101 Protein in Ovarian Carcinomas Revealed by Proteomics Analyses. Mol Cell Proteomics, 2007 Feb; 6(2): 294-304.
  59. Yang G#, Rosen DG, Mercado-Uribe I, Colacino JA, Mills GB, Bast RC Jr, Zhou C, Liu J. Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells. Carcinogenesis, 2007 Jan; 28(1): 174-82.
  60. Rosen DG, Mercado-Uribe I, Yang G, Bast RC Jr, Amin HM, Lai R, Liu J. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer, 2006 Dec 1; 107(11): 2730-40.
  61. Wen XF, Yang G, Mao W, Thornton A, Liu J, Bast RC Jr, Le XF. HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy. Oncogene, 2006 Nov 2; 25(52): 6986-96.
  62. Rosen DG#, Yang G#, Bast RC Jr, Liu J.Use of ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer. Methods Enzymol, 2006; 407: 660-76.
  63. Yang G#, Rosen DG, Zhang Z, Bast RC Jr, Mills GB, Colacino JA, Mercado-Uribe I, Liu J.The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc Natl Acad Sci U S A, 2006 Oct 31; 103(44): 16472-7.
  64. Rosen DG,Yang G, Deavers MT, Malpica A, Kavanagh JJ, Mills GB, Liu J.Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma. Cancer, 2006 May 1; 106(9): 1925-32.
  65. Hu Y, Rosen DG, Zhou Y, Feng L, Yang G, Liu J, Huang P.Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. J BiolChem, 2005 Nov 25; 280(47): 39485-92.
  66. Rosen DG,Yang G, Cai KQ, Bast RC Jr, Gershenson DM, Silva EG, Liu J.Subcellular localization of p27kip1 expression predicts poor prognosis in human ovarian cancer. Clin Cancer Res, 2005 Jan 15; 11(2 Pt 1): 632-7.
  67. Young TW, Mei FC,Yang G, Thompson-Lanza JA, Liu J, Cheng X.Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry. Cancer Res, 2004 Jul 1; 64(13): 4577-84.
 
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