专职PI
杨恭 研究员
研究员,博士生导师
E-mail: yanggong@fudan.edu.cn
 

  2001年毕业于中国科学院微生物研究所,获得博士学位。2001年至2005年先后在美国休斯敦霍华德·休斯医学研究所、美国M.D. Anderson肿瘤中心从事博士后研究工作。2005年任美国德克萨斯大学M.D. Anderson癌症研究中心病理系讲师,并于2008年升职为美国德克萨斯大学M.D. Anderson癌症研究中心病理系助理教授。2010年回国工作,担任复旦大学附属肿瘤医院研究所研究员,博士生导师,实验研究中心/研究所副主任。20126-8月作为客座教授在日本金沢大学癌症研究所工作。2013年至今,任复旦大学附属肿瘤医院研究所研究员,博士生导师,妇科肿瘤/肿瘤化疗研究课题组长/PI;复旦大学附属上海市第五人民医院特聘教授,博士生导师,中心实验室常务副主任,组织样本库/慢性病平台负责人。杨恭教授目前在Nature Communications,Molecular Cancer、JNCI、PNAS、Clin Cancer Res、JBC、Cancer Res、Theranotics、Molecular Therapy、Oncogene、Cancer letter、European Journal of Cancer、International Journal of Cancer等国际知名杂志上发表SCI论文近70余篇。主持国家自然科学基金/重大研发计划5项,教育部博士点基金博导类1项;上海市浦江人才计划1项;上海市卫生局局级基金2项;参与科技部重大研发计划(子课题)精准医学项目 1项,重大慢性非传染性疾病项目(子课题)1项。


研究领域:

  1. 肿瘤微环境IL-8ECM1促进肿瘤转移复发、干细胞分化和化疗抵抗的机制;
  2. 细胞永生化与转化动物模型构建及分析;
  3. 细胞衰老与恶性转化;
  4. RAS/P53相关基因突变与细胞凋亡、衰老以及EMT、自噬的关系;
  5. 肿瘤靶向药物的筛选与开发;
  6. DNA损伤修复与肿瘤放化疗抵抗及其与肿瘤干细胞调控的机制。


研究团队:


  现有研究助理1名,技术员1名,共培养博士研究生12名,硕士研究生6名。


代表性论著:

  1. Huijing Yin# , Jingshu Wang#, Hui Li#, Yinjue Yu#, Xiaoling Wang, Lili Lu, Cuiting Lv, Bin Chang, Wei Jin, Wenwen Guo, Chunxia Ren*, Gong Yang*. Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness. Nature Communications. 2021 Jul 9; 12(1):4230.
  2. Jiao Meng#, Kaiyi Liu#, Yang Shao#, Xu Feng, Zhaodong Ji, Bin Chang, Yan Wang*, Ling Xu* Gong Yang*. ID1 confers cancer cell chemoresistance through STAT3/ATF6-mediated induction of autophagy. Cell Death & Disease. 2020 Feb 20; 11(2):137.
  3. Yang Shao#, Xiaomin Liu#, Jiao Meng#, Xiaofei Zhang, Zhongliang Ma*, Gong Yang*. MicroRNA-1251-5p Promotes Carcinogenesis and Autophagy via Targeting the Tumor Suppressor TBCC in Ovarian Cancer Cells. Molecular Therapy. 2019 Sep 4; 27(9):1653-64.
  4. Xiaofei Zhang#, Zihao Qi#, Huijing Yin, Gong Yang*. Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy. Theranostics.2019 Jan 30; 9(4):1096-114.
  5. Yan Wang #, Ziliang Wang#, Zihao Qi, Sheng Yin, Na Zhang, Yang Liu, Mingming Liu, Jiao Meng, Rongyu Zang*, Zhen Zhang*, Gong Yang*. The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. Mol Cancer, 2014 Apr 28; 13:94. 
  6. Gong Yang#, Xue Xiao, Daniel G. Rosen, Xi Cheng, Xiaohua Wu, Bin Chang, Guangzhi Liu, Fengxia Xue, Mercado-Uribe Imelda, Paul Chiao, Xiang Du, Jinsong Liu*. The Biphasic Role of NF-{kappa}B in Tumor Progression and Chemoresistance of Ovarian Cancer. Clin Cancer Res, 2011 Apr 15; 17(8):2181-94.
  7. Gong Yang#, Daniel G. Rosen, Guangzhi Liu, Fan Yang, Xiaoqing Guo, Xue Xiao, Fengxia Xue, Mercado-Uribe Imelda, Jiaoti Huang, Sue-Hwa Lin, Gordon B. Mills, Jinsong Liu*.CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis. Clin Cancer Res, 2010 Aug 1; 16(15):3875-86.
  8. Gong Yang#, Bin Chang, Fan Yang, Xiaoqing Guo, Kathy Qi Cai, Xue (Sherry)Xiao, Huamin Wang, Subrata Sen, Mien-Chie Hung, Gordon B. Mills, Sandy Chang, Asha S. Multani, Mercado-Uribe Imelda, Jinsong Liu*. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res, 2010 Jun 15; 16(12):3171-81.
  9. Guangzhi Liu#, Gong Yang #, Bin Chang, Imelda Mercado-Uribe, Miao Huang, Jingfang Zheng, Robert C. Bast, Sue-Hwa Lin, Jinsong Liu*. Stanniocalcin 1 and ovarian tumorigenesis. J Natl Cancer Inst, 2010 Jun 2; 102(11):812-27.
  10. Gong Yang#, Daniel G Rosen, Zhihong Zhang, Robert C Bast Jr, Gordon B Mills, Justin A Colacino, Imelda Mercado-Uribe, Jinsong Liu*. The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis.  PNAS. 2006 Oct 31; 103(44):16472-7.
 
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