专职PI
金伟 研究员
研究员,博士生导师
E-mail: jinwei7207@163.com
 

      2006年9月回国来到复旦大学附属肿瘤医院乳腺癌研究所工作。作为课题负责人,主持了多项国家自然科学基金,以及教育部新世纪优秀人才基金、上海市浦江人才计划基金、上海市卫生计生系统优秀学科带头人基金、上海市教委科研创新项目、教育部留学回国人员启动基金、上海市自然科学基金等多项省部级基金;已在国内外期刊杂志上发表论文60余篇,其中SCI论文40余篇,论文发表于Cancer ResearchJ Biol ChemMol Cell BiolBreast Cancer Res TreatBiochem Pharmacol 等学术杂志;担任国家自然科学基金、国家科学技术奖励等项目和奖励的通讯评议专家;担任8家SCI杂志审稿人,还担任中国抗癌协会抗癌药物专业委员会委员、上海市抗癌协会乳腺癌专业委员会委员等社会学术职务。


研究领域:

  主要从事乳腺癌转移相关的研究,目前主要研究方向包括:
  1.线粒体相关基因在乳腺癌转移中的作用;
  2.转录因子与乳腺癌发生发展的研究。


研究团队:

  小组成员共6位:孙荷芬(研究助理)、杨雪丽(技术员)、傅文燕(博士研究生)、赵阳(博士研究生)、赵源源(博士研究生)、陈梦婷(硕士研究生)。


代表性论著:

  1. Huang S, Chi Y, Qin Y, Wang Z, Xiu B, Su Y, Guo R, Guo L, Sun H, Zeng C, Zhou S, Hu X, Liu S, Shao Z, Wu Z, Wei J*, Wu J*. CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription. Theranostics, 2018; 8(9): 2549-2564.

  2. Chen MT, Sun HF, Li LD, Zhao Y, Yang LP, Gao SP, Jin W*. Downregulation of FOXP2 promotes breast cancer migration and invasion through TGFβ/SMAD signaling pathway. Oncol Lett, 2018 Jun; 15(6): 8582-8588.

  3. Zhao Y, Sun HF, Chen MT, Gao SP, Li LD, Jiang HL, Jin W*. Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population-based study. Cancer Med, 2018 Jun; 7(6):2307-2318.

  4. Yang LP, Sun HF, Zhao Y, Chen MT, Zhang N*, Jin W*. Clinicopathological characteristics and survival outcomes in pleomorphic lobular breast carcinoma of the breast: a SEER population-based study. Cancer Med, 2017 Dec; 6(12):2867-2875.

  5. Chen MT, Sun HF, Zhao Y, Fu WY, Yang LP, Gao SP, Li LD, Jiang HL, Jin W*. Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis. Sci Rep, 2017 Aug 23; 7(1):9254.

  6. Gao SP, Sun HF, Li LD, Fu WY, Jin W*. UHRF1 promotes breast cancer progression by suppressing KLF17 expression by hypermethylating its promoter. Am J Cancer Res, 2017 Jul 1; 7(7):1554-1565.

  7. Gao SP, Sun HF, Fu WY, Li LD, Zhao Y, Chen MT, Jin W*. High expression of COX5B is associated with poor prognosis in breast cancer. Future Oncol, 2017 Aug;13(19):1711-1719.

  8. Jiang HL, Sun HF, Gao SP, Li LD, Huang S, Hu X, Liu S, Wu J, Shao ZM, Jin W*. SSBP1 Suppresses TGFβ-Driven Epithelial-to-Mesenchymal Transition and Metastasis in Triple-Negative Breast Cancer by Regulating Mitochondrial Retrograde Signaling. Cancer Res, 2016 Feb 15; 76(4):952-64.

  9. Li LD, Sun HF, Liu XX, Gao SP, Jiang HL, Hu X, Jin W*. Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism. PLoS One, 2015 Dec 7; 10(12).

  10. Wang Q, Li J, Yang X, Sun H, Gao S, Zhu H, Wu J, Jin W*. Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene. Acta Biochim Biophys Sin (Shanghai), 2013 Mar; 5(3):179-87.

  11. Wei Jin#, Bo-bin Chen, Ji-yu Li, Hua Zhu, Mark Huang, Sheng-mei Gu, Qiao-qiao Wang, Jia-ying Chen, Sanjian Yu, Jiong Wu, Zhi-ming Shao. TIEG1 inhibits breast cancer invasion and metastasis by inhibition of EGFR transcription and the EGFR signaling pathway. Mol Cell Biol, 2011; 32(1):50-63.

  12. Wei Jin#, Ying Chen, Genhong Di, Penelope Miron, Yifeng Hou, Hui Gao, Zhimin Shao. ERβ or P53 attenuates ERα-mediated transcriptional activation on the BRCA2 promoter. J Biol Chem, 2008; 283(44):29671-29680.

 
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