|
|
柳素玲,复旦大学生物医学研究院和肿瘤医院双聘教授, 博士研究生导师,国家“优秀青年”科学基金获得者;科技部中青年科技创新领军人才获得者。中国科学技术大学生物系获得学士学位;美国俄亥俄州立大学获得博士学位; 2003-2010年在美国密歇根大学癌症研究中心从事癌症干细胞博士后研究工作; 2010-2012年任美国密歇根大学医学院助理教授。2005-2008年获美国苏珊-库门癌症基金会博士后奖,2006 年获美国癌症协会默克学者奖,2010年获美国癌症协会苏珊-库门学者奖,2014年获得USCACA‐NFCR 学术奖, 2018年获得中国肿瘤青年科学家奖,2019年获得上海市医学领军人才称号,2020年获得科技部中青年科技创新领军人才称号。近五年,作为通讯作者在Nature Cell Biology、Advanced Science、Nature Communications、Science Advances、Cancer Res.、Plos Biology、Clinical Cancer Res.、Molecular Cancer等国际杂志上共发表论文25篇。共发表SCI论文78篇,总影响因子超过500,论文总他引超过10000次。现任World Journal of Stem
Cells和ISRN cell biology等国际期刊编委。共申请国际专利五项、中国专利四项。作为独立研究PI,获得美国Susan G Komen Foundation 研究资助;美国国防部(DOD)研究资助;美Astrazeneca/Medimmune公司研究资助;中国科学院干细胞与再生医学先导项目资助;国家自然科学基金委“优青”项目、重点项目(2项)和面上项目资助;获得科技部国家重点研发计划和973子课题项目资助。
研究领域:
1)乳腺肿瘤干细胞的异质性及其调控和耐药研究;
2)乳腺肿瘤干细胞的起源研究;
3)肿瘤微环境与肿瘤干细胞的互作研究;
4)肿瘤干细胞的免疫调控研究;
5)靶向肿瘤干细胞的新型治疗策略研究及药物开发。
研究团队:
代表性论著:
-
Huang, Y.#,
Wang, H., Hao, Y., Lin, H., Dong, M., Ye, J., Song, L., Wang, Y., Li, Q., Shan,
B., Jiang, Y., Li, H., Shao, Z.M., Kroemer, G., Zhang, H., Bai, L., Jin, T.,
Wang, C., Ma, Y., Cai, Y., Ding, C., Liu, S.*, Pan, Y.*, Jiang, W.*, Zhou R.*. Myeloid PTEN promotes
chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Nature
Cell Biology (online), 2020.
-
Zhang, F. #, Liu, S.*. Mechanistic insights of adipocyte metabolism in regulating
breast cancer progression. Pharmacological Research, 2020 May; 155:104741.
-
Qin, Y. #, Chen,
W. #, Jiang, G., Zhou, L., Yang, X., Li, H., He, X., Wang, H., Zhou,
Y., Huang, S., Liu, S.*. Interfering
MSN-NONO complex activated CREB signaling serves a novel therapeutic strategy
for triple-negative breast cancer. Science Advances, 2020 Feb 19; 6(8).
-
Zhang, L. #,
Qiang, J. #, Yang, L. #, Wang, D., Adeel, R., He, X.,
Chen, W., Sheng , D., Zhou, L., Jiang, Y. Z., Li, T., Du, Y., Feng, J., Hu, X.,
Zhang, J., Hu, X. C., Shao, Z. M., Liu,
S.*. IL1R2 blockade suppresses
breast tumorigenesis and progression by impairing USP15-dependent BMI1
stability. Advanced Science, 2019 Nov 13; 7(1):1901728.
-
Zhou, L. #,
Wang, D. #, Sheng, D. #, Xu, J., Chen, W., Qin, Y., Du,
R., Yang, X., He, X., Xie, N.*, Liu, S.*,
Zhang, L.*. NOTCH4 maintains quiescent mesenchymal-like breast cancer stem
cells via transcriptionally activating SLUG and GAS1 in triple-negative breast
cancer. Theranostics, 2020 Jan 19; 10(5):2405-2421.
-
Zhang, J. #, Yang, Y., Zhou, S., He, X., Cao, X., Wu, C., Hu,
H., Qin, J., Wei, G., Wang, H., Liu, S.*,
Sun, L.*. Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced
cancer cytolysis via juxtacrine inter-cancer-cell death signaling. Cell Death
and Differentiation,2020 May; 27(5):1569-1587.
-
Jiang, G.#, Wang, X.#,
Sheng, D., Zhou, L., Liu, Y., Xu, C., Liu,
S.* and Zhang, J.*. Cooperativity of co-factor NR2F2 with Pioneer Factors GATA3,
FOXA1 in promoting ERα
function. Theranostics, 2019
Aug 21; 9(22):6501-6516.
-
Jin, X. #, Xu, X-E. # *, Jiang, Y-Z. #, Liu, Y-R., Sun, W., Guo, Y-J., Ren, Y-X., Zuo,
W-J., Hu, X., Huang, S-L., Shen, H-J., Lan, F., He, Y-F., Hu, G-H., Di, G-H.,
He, X-H., Li, D-Q., Liu, S.*, Yu, K-D.*,Shao,
Z-M.*. The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8
degradation. Science Advances, 2019 Mar 6; 5(3):eaat9820.
-
Cui, B. #, Luo, Y., Tian, P., Peng,
F., Lu, J., Yang, Y., Su, Q., Liu, B., Yu, J., Luo, X., Yin, L., Cheng, W., An,
F., He, B., Liang, D., Wu, S., Chu, P., Song, L., Liu, X., Luo, H., Xu, J.,
Pan, Y., Wang, Y., Li, D., Huang, P., Yang, Q., Zhang, L., Zhou, B.P., Liu, S., Xu, G., Lam, E.W.-F., Kelley, K.W. and Liu, Q.*.
Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast
cancer stem-like cells. JCI, 2019 Mar 1; 129(3):1030-1046.
-
Liu, J. #, Duan, Z. #, Guo, W., Zeng, L., Wu, Y., Chen,
Y., Tai, F., Wang, Y., Lin, Y., Zhang, Q., He, Y., Deng J., Stewart, R., Wang,
C., Lin, P., Ghaffari, S., Evers, B.M., Liu,
S.*, Zhou, M-M.*, Zhou, B.*, and Shi, J.*. Targeting the BRD4/FOXO3a/CDK6
axis Sensitizes AKT Inhibition in Luminal Breast Cancer. Nature Communications 2018; 9(1): 5200.
-
Liu, B. #, Du, R. #, Zhou L., Xu, J., Chen, S., Chen,
J., Yang, X., Liu, D-X., Shao, Z-M., Zhang, L., Yu, Z., Xie, N. *,
Guan, J-L.*, and Liu, S.*. miR-200c/141 regulates breast cancer stem cell heterogeneity via
targeting HIPK1/β-catenin axis. Theranostics 2018; 8(21): 5801-5813.
-
Deng, L. #, Gao, X. #, Liu, B., He, X., Xu, J., Qiang,
J., Wu, Q., Liu, S.*. NMT1
inhibition modulates
breast cancer progression through stress-triggered JNK pathway. Cell
Death and Disease, 2018; 9(12):1143.
-
Chen, L-L. #, Lin, H-P. #,
Zhou, W-J., He, C-X., Zhang, Z-Y., Cheng, Z-L., Song, J-B., Liu, P., Chen,
X-Y., Xia, Y-K., Chen, X-F., Sun, R-Q., Zhang, J-Y., Sun, Y-P., Song, L., Liu,
B-J., Du, R-K., Ding, C., Lan, F., Huang, S-L., Zhou, F., Liu, S., Xiong, Y.*, Ye, D.*, Guan, K-L.* SNIP1 recruits TET2 to regulate c-MYC target
genes and cellular DNA damage response. Cell Reports, 2018; 25(6):1485-1500.
-
Chen, W. #, Qin, Y. #, Wang, D., Zhou, L., Liu, Y.,
Chen, S., Yin, L., Xiao, Y., Yao, X-H., Yang, X., Ma, W., Chen, W., He, X.,
Zhang, L., Yang, Q., Bian, X., Shao, Z-M., Liu,
S.* CCL20 triggered by chemotherapy hinders the therapeutic efficacy of
breast cancer. Plos Biology,
2018; 16(7): e2005869.
-
Chen, F. #, Long, Q., Fu, D., Zhu,
D., Ji, Y., Han, L., Zhang, B., Xu, Q., Liu, B., Li, Y., Wu, S., Yang, C.,
Qian, M., Xu, J., Liu, S., Cao, L.,
Chin, E.Y., Lam, E.W.F., Coppé, J-P., Sun, Y. Targeting SPINK1 in the damaged
tumour microenvironment alleviates therapeutic resistance. Nature Communications,
2018; 9: 4315.
-
Liu, M. #, Liu, Y. #, Deng, L. #, Wang,
D., He, X., Zhou, L., Wicha, M.S., Bai, F.*, Liu, S.*. Transcriptional profiles of different
states of cancer stem cells in triple-negative breast cancer. Molecular Cancer, 2018; 17(1): 65.
-
Du, R. #, Liu, B. #, Zhou, L., Wang, D., He, X.,
Xu, X., Zhang, L., Niu, C.*, Liu, S.*. Downregulation of annexin A3 inhibits tumor
metastasis and decreases drug resistance in breast cancer. Cell
Death and Disease, 2018; 9(2): 126.
-
Wang, D. #, Xu, J. #, Liu,
B., He, X., Zhou, L., Hu, X., Qiao, F., Zhang, A., Xu, X., Zhang, H., Wicha,
MS., Zhang, L., Shao, Z., Liu, S.*. IL6 blockade potentiates the anti-tumor effects
of γ-secretase inhibitors in Notch3-expressing breast cancer. Cell
Death and Differentiation, 2018;
25(2): 330-339.
-
Zhou, L. #, Sheng, D. #,
Deng, Q., Wang, D., Liu, S.*. Development of a novel method for rapid
cloning of shRNA vectors, which successfully knocked down CD44 in
mesenchymal-like triple negative breast cancer cells. Cancer Communications,
2018 Sep 24; 38(1):57.
-
Zhou, L. #, Sheng, D. #,
Wang, D., Ma, W., Deng, Q., Deng, L., Liu,
S.*. Identification of cancer-type specific
expression patterns for active aldehyde dehydrogenase (ALDH) isoforms in
ALDEFLUOR assay. Cell Biol
Toxicol,
2019 Apr; 35(2):161-177.
-
Chen, W. #, Qin, Y. #, Liu, S.*. Cytokines, breast cancer stem cells
(BCSCs) and chemoresistance. Clinical
and Translational Medicine, 2018 Sep 3; 7(1):27.
-
Qin,
Y. #, Chen, W. #, Liu, B., Zhou, L., Deng,
L., Niu, W., Bao, D., Cheng, C., Li, D., Liu, S.*, Niu, C.*. MiR-200c Inhibits
the Tumor Progression of Glioma via Targeting Moesin. Theranostics, 2017 Apr 10; 7(6):1663-1673.
-
Wang,
D. #, Du, R., Liu, S.*. Rad51
inhibition sensitizes breast cancer stem cells to PARP inhibitor in
triple-negative breast cancer. Chin J Cancer, 2017;
36(1):37.
-
Xu,
J. #, Liu, S.*.
Research progress in breast cancer stem cells. Scientia Sinica Vitae,
2017.
-
Liu,
Y. #, Burness, M.L.,
Martin-Trevino, R., Guy, J., Bai, S., Harouaka, R., Brooks, M.D., Shang, L.,
Fox, A., Luther, T.K., Davis, A., Baker, T.L., Colacino, J., Clouthier, S.G.,
Shao, Z-M., Wicha, M.S., and Liu, S*. RAD51 Mediates Resistance
of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer. Clinical
Cancer Research, 2017; 23(2): 514-522.
-
Liu,
R. #, Shi, P., Nie, Z., Liang,
H., Zhou, Z., Chen, W., Chen, H., Dong, C., Yang, R., Liu, S.,
Chen, C.* Mifepristone Suppresses
Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5
Expression. Theranostics, 2016 Feb 13; 6(4):533-544.
-
Zhao,
Z. #, Li, S., Song, E., and Liu,
S*. The roles of ncRNAs and
histone-modifiers in regulating breast cancer stem cells. Protein
& cell, 2016 Feb; 7(2):89-99.
-
Liu,
Y. #, Chen, C., Qian, P., Lu,
X., Sun, B., Zhang, X., Wang, L., Gao, X., Li, H., Chen, Z., Tang, J., Zhang,
W., Dong, J., Bai, R., Lobie, P. E., Wu, Q., Liu, S., Zhang, H.,
Zhao, F., Wicha, M. S., Zhu, T., and Zhao, Y. Gd-metallofullerenol nanomaterial
as non-toxic breast cancer stem cell-specific inhibitor. Nature
Communications, 2015 Jan 23; 6:5988.
-
Sun,
S. #, Liu, S., Duan,
S. Z., Zhang, L., Zhou, H., Hu, Y., Zhou, X., Shi, C., Zhou, R., and Liu, S.*
#, Cong, Y., Wang, D., Sun, Y., Deng, L., Liu, Y., Martin-Trevino, R., Shang,
L., McDermott, S. P., Landis, M. D., Hong, S., Adams, A., D'Angelo, R.,
Ginestier, C., Charafe-Jauffret, E., Clouthier, S. G., Birnbaum, D., Wong, S.
T., Zhan, M., Chang, J.C.*, and Wicha, M.S.* Breast Cancer Stem Cells
Transition between Epithelial and Mesenchymal States Reflective of their Normal
Counterparts. Stem Cell Reports, 2013 Dec 27; 2(1):78-91.
-
Deng,
L. #, Shang, L. #, Bai, S., Chen, J., He,
X., Martin-Trevino, R., Chen, S., Li, X.-Y., Meng, X., Yu, B., Wang, X., Liu,
Y., McDermott, S. P., Ariazi, A. E., Ginestier, C., Ibarra, I., Ke, J., Luther,
T., Clouthier, S. G., Xu, L., Shan, G., Song, E., Yao, H., Hannon, G. J.,
Weiss, S. J., Wicha, M. S., and Liu, S.*. MicroRNA100 Inhibits
Self-Renewal of Breast Cancer Stem-like Cells and Breast Tumor Development. Cancer
research, 2014 Nov 15; 74(22):6648-60.
-
Liu,
S.* #, Patel, S. H., Ginestier, C., Ibarra, I.,
Martin-Trevino, R., Bai, S., McDermott, S. P., Shang, L., Ke, J., Ou, S. J.,
Heath, A., Zhang, K. J., Korkaya, H., Clouthier, S. G., Charafe-Jauffret, E.,
Birnbaum, D., Hannon, G. J., and Wicha, M.S*. MicroRNA93 Regulates
Proliferation and Differentiation of Normal and Malignant Breast Stem
Cells. Plos Genetics, 2012; 8(6):e1002751.
-
Liu,
S. #, Clouthier, S. G., and
Wicha, M.S.* Role of microRNAs in the Regulation of Breast Cancer Stem
Cells. Journal of Mammary Gland Biology and Neoplasia,
2012; 17: 15-21.
-
Liu,
S.* #, Ginestier, C., Ou, S. J.,
Clouthier, S. G., Patel, S. H., Monville, F., Korkaya, H., Heath, A., Dutcher,
J., Kleer, C. G., Jung, Y., Dontu, G., Taichman, R., and Wicha, M.S.* Breast
Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine
Networks. Cancer Research, 2011 Jan 15; 71(2):614-24.
-
Liu,
S. #, and Wicha, M. S.
Targeting Breast Cancer Stem Cells. Journal of Clinical Oncology,
2010; 28:4006-4012.
-
Ginestier,
C., Liu, S., Diebel, M. E., Korkaya, H., Luo, M., Brown, M.,
Wicinski, J., Cabaud, O., Charafe-Jauffret, E., Birnbaum, D., Guan, J.-L.,
Dontu, G., and Wicha, M. S. CXCR1 blockade selectively targets human breast
cancer stem cells in vitro and in xenografts. Journal of Clinical
Investigation, 2010 Feb; 120(2):485-97.
-
Ginestier,
C., Liu, S., and Wicha, M. S. Getting to the Root of
BRCA1-Deficient Breast Cancer. Cell Stem Cell, 2009
Sep 4; 5(3):229-30.
-
Liu,
S. #, Ginestier, C.,
Charafe-Jauffret, E., Foco, H., Kleer, C. G., Merajver, S. D., Dontu, G., and
Wicha, M. S. BRCA1 regulates human mammary stem/progenitor cell fate. Proceedings
of the National Academy of Sciences of the United States of America,
2008 Feb 5; 105(5):1680-5.
-
Ginestier,
C., Hur, M. H., Charafe-Jauffret, E., Monville, F., Dutcher, J., Brown, M.,
Jacquemier, J., Viens, P., Kleer, C. G.,Liu, S., Schott, A., Hayes, D.,
Birnbaum, D., Wicha, M. S., and Dontu, G. ALDH1 is a marker of normal and
malignant human mammary stem cells and a predictor of poor clinical
outcome. Cell Stem Cell, 2007 Nov; 1(5):555-67.
-
Liu,
S. #, Dontu, G., Mantle, I.,
Patel, S., Ahn, N., Jackson, K., Suri, P., and Wicha, M. Hedgehog signaling and
Bmi-1 regulate self-renewal of normal and malignant human mammary stem
cells. Cancer Research, 2006 Jun 15; 66(12):6063-71.
Book Chapters
-
Chen, W., Qin, Y., and Liu, S.*. CCL20 Signaling in the Tumor Microenvironment. Tumor Microenvironment. Chapter 6, Page 53-65, 2020 (Springer)
-
Xu, J., and Liu, S.*. Non-coding RNAs in
cancer cell plasticity. The long and short non-coding RNAs in
cancer biology. Chapter 6, Page
137-172, 2016 (Springer).
-
Deng, L., Xu, J., Wang, D. and Liu,
S.*. Self-Renewal Pathways in
Mammary Stem Cells and Carcinogenesis. Cancer Stem Cells: Emerging Concepts and Future
Perspectives in Translational Oncology. Chapter 6, Page
155-174, 2015.
-
Ouzounova, M., Liu, S. and
Wicha, M.S. Stem Cells in Breast Development and Carcinogenesis: Concepts and
Clinical Perspectives. Diseases of the breast. 5th edition, Chapter 2, Page 15-24, 2014.
-
Liu, Y. and Liu, S.*. Role of Cancer Stem
Cell in Mammary Carcinogenesis and Its Clinical Implication. Stem Cells and
Cancer Stem Cells. Vol 10, 189-197, 2013.
-
Mantle, I., Dontu, G., Liu, S. and Wicha, M.S. Cancer stem
cells: implications for development of more effective therapies. Cancer
drug resistance. PART II:
Biological Resistance. 2005.
|