雷群英 教授 教授，博士生导师 E-mail: qlei@fudan.edu.cn

教育经历
博士   1999 - 2002  复旦大学生物化学与分子生物学系
硕士   1996 - 1999  苏州大学生物化学与分子生物学系
学士   1988 - 1993  南昌大学预防医学专业

工作经历

教授   2017 - 今    复旦大学附属肿瘤医院/生物医学研究院
教授   2009 - 2016  复旦大学基础医学院/生物医学研究院
副教授 2006 - 2009  复旦大学基础医学院/生物医学研究院
博士后 2003 - 2006  加州大学洛杉矶分校分子与医学药理系  Hong Wu实验室
博士后 2002 - 2003  加州大学洛杉矶分校儿科系 Robert H Lane实验室

重要学术贡献

    雷群英教授长期致力于营养和肿瘤代谢的研究，揭示了代谢物（营养组分）及代谢酶调控肿瘤细胞表观遗传和翻译后修饰的作用和机制；以胰腺癌为突破口，系统阐明了代谢重塑在胰腺癌早期发生中的关键作用及其代谢靶向干预。这些研究为肿瘤代谢的修正治疗，包括饮食/营养控制（精准饮食）和代谢酶的靶向干预等提供了理论支持和潜在靶点。成果以通讯作者在Nat Cell Biol, Cancer Cell, Cell Metab, Mol Cell (5篇), J Clin Invest（2篇）等，SCI总他引1万多次，受到Nature, Nat Cell Biol, Nat Rev Cancer, Cancer Discovery, Mol Cell等杂志专题评述或选为亮点/封面文章，受到J Biol Chem等邀请综述。目前实验室重点关注代谢物感知、细胞代谢可塑性及肿瘤代谢异质性调控研究。作为项目负责人先后获得科技部国家重大/重点研发计划项目和基金委创新研究群体、国家杰出青年基金、重大、重点等项目资助, 入选长江特聘教授（2015），享受政府特殊津贴。荣获中国青年女科学家奖、上海市自然科学牡丹奖、上海市育才奖、上海市自然科学一等奖（第一）、谈家桢生命科学创新奖和全国三八红旗手等荣誉。目前担任中国细胞生物学会细胞代谢分会主委，中国生物化学与分子生物学基础医学分会副理事长和上海市生物化学与分子生物学会副理事长。

研究领域：营养与肿瘤代谢

1.营养/代谢物感知及其调控机制；

2.肿瘤代谢重塑过程中关键代谢酶的功能和调控机制；

3.肿瘤代谢与肿瘤微环境的相互作用和异质性。

研究团队：

代表性论著：(*为通讯作者)

1. Li JT^#, Yin M^#, Wang D^#, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY*. BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma. Nature Cell Biology, 2020; 22(2):167-174. Highlighted in “News & Views” of Nature Cell Biology.
2. Liu Y^#, Guo JZ^#, Liu Y^#, Wang K, Ding WC, Wang H, Liu X, Zhou ST, Lu XC, Yang HB, Xu CY, Gao W, Zhou L, Wang YP, Hu WG, Wei YQ, Huang CH*, Lei QY*. Nuclear Lactate Dehydrogenase A Senses ROS to Produce α-Hydroxybutyrate for HPV-Induced Cervical Tumor Growth. Nature Communications. 2018 Oct 24; 9(1):4429.
3. Xia S, Lin R, Jin L, Zhao L, Kang HB, Pan Y, Liu S, Qian G, Qian Z, Konstantakou E, Zhang B, Dong JT, Chung YR, Abdel-Wahab O, Merghoub T, Zhou L, Kudchadkar RR, Lawson DH, Khoury HJ, Khuri FR, Boise LH, Lonial S, Lee BH, Pollack BP, Arbiser JL, Fan J*, Lei QY*, Chen J*. Prevention of Dietary-Fat-Fueled ketoqenesis Attenuates BRAF V600E Tumor Growth. Cell Metabolism. 2017 Feb 7; 25(2):358-373. Highlighted in “Research Highlights” in Nature.
4. Wang YP^#*, Zhou W, Wang J, Huang X, Zuo Y, Wang TS, Gao X, Xu YY, Zou SW, Liu YB, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer. Molecular Cell. 2016 Nov 17; 64(4):673-687. Highlighted in “Research Watch” in Cancer Discovery..
5. Gao X^#, Lin SH^#, Ren F, Li JT, Chen JJ, Yao CB, Yang HB, Jiang SX, Yan GQ, Wang D, Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang PY*, Lei QY*. Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia. Nature Communication. 2016 Jun 30; 7:11960.
6. Zhao D^#, Mo Y, Li MT, Zou SW, Cheng ZL, Sun YP, Xiong Y*, Guan KL*, Lei QY*. NOTCH-induced Aldehyde Dehydrogenase 1A1 Deacetylation Promotes Breast Cancer Stem Cells. Journal of Clinical Investigation. 2014 Dec; 124(12):5453-65. Highlighted in “Breaking Advances” in Cancer Research.
7. Lv L^#, Xu YP^#, Zhao D, Li FL, Wang W, Sasaki N, Jiang Y, Zhou X, Li TT, Guan KL*, Lei QY*, Xiong Y*. Mitogenic and Oncogenic Stimulation of K433 Acetylation Promote PKM2 Protein Kinase Activity and Nuclear Localization. Molecular Cell. 2013 Nov 7; 52(3):340-52. Cover Story in Molecular Cell and Highlighted in “Research Watch” in Cancer Discovery and “Research Highlights” in Nature Reviews Cancer.
8. Lin R^#, Tao R^#, Gao X, Li T, Zhou X, Guan KL, Xiong Y, Lei QY*. Acetylation Stabilizes ATP-citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth. Molecular Cell. 2013 Aug 22; 51(4):506-518.
9. Zhao D^#, Zou SW^#, Liu Y, Zhou X, Mo Y, Wang P, Xu YH, Dong B, Xiong Y*, Lei QY*, Guan KL*. Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer. Cancer Cell. 2013 Apr 15; 23(4):464-76.
10. Lv L^#, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Liu Y, Li Z, Xu Y, Wang G, Huang Y, Xiong Y, Guan KL, Lei QY*. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell. 2011 Jun 24; 42(6):719-30. Selected as Featured Article and Previewed in Molecular Cell and Recommended by Prof. Lewis Cantley in F1000.