黄胜林 研究员 研究员，博士生导师 E-mail: slhuang@fudan.edu.cn

　　2003年于福建医科大学获临床医学学士学位，2006年与2009年于上海交通大学医学院获生物化学与分子生物学硕士学位及肿瘤学博士学位。2009年博士毕业后留在上海市肿瘤研究所癌基因及相关基因国家重点实验室工作，2011年至2013年在斯坦福大学医学院做博士后，2013年9月起任复旦大学附属肿瘤医院/肿瘤研究所和生物医学研究院PI。主要从事肿瘤表观遗传和生物信息学研究，建立了相关的RNA测序、生物信息方法和数据库（exLR-seq，ASJA，exoRBase），提出癌症中存在丰富的肿瘤特异转录本，解析细胞外囊泡/外泌体内新的RNA组分和应用。迄今发表SCI论文40余篇，被引超过3000次，主要研究成果发表于Nature Cell Biology, Cell Research, Nature Communications, Gut, Hepatology, Nucleic Acids Research, Cell Reports等专业杂志上。主持国家自然基金项目4项，申请发明专利3项，作为主要完成人获教育部自然科学奖二等奖及上海医学科技奖二等奖。

研究领域：

　　肿瘤表观遗传及生物信息学研究，主要包括：
　　1. 肿瘤相关RNA/特异转录本鉴定及在肿瘤中的作用机制和应用研究；
　　2. 血液细胞外囊泡/外泌体RNA鉴定及生物信息分析在肿瘤中的应用研究。

研究团队：

　　研究助理：   李焱 博士、郑秋鹏 博士
　　博士研究生：李玉琛、赖洪燕
　　硕士研究生：赵晶晶、黎  琴

代表性论著：

1. Qiupeng Zheng^#, Jingjing Zhao^#, Hui Yu, Huajie Zong, Xigan He, Yiming Zhao, Yan Li, Yu Wang, Yichao Bao, Yuchen Li, Bing Chen, Weijie Guo, Yilin Wang, Zhiao Chen, Yingjun Zhao, Lu Wang*, Xianghuo He*, Shenglin Huang*. Tumor-specific Transcripts are Frequently Expressed in Hepatocellular Carcinoma with Clinical Implication and Potential Function. Hepatology. 2019. DOI: 10.1002/hep.30805
   
2. Yu S^#, Li Y^#, Liao Z^#, Wang Z^#, Wang Z, Li Y, Qian L, Zhao J, Zong H, Kang B, Zou WB, Chen K, He X, Meng Z, Chen Z*, Huang S*, Wang P*. Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for the detection of pancreatic ductal adenocarcinoma. Gut. 2019. doi: 10.1136/gutjnl-2019-318860.
3. Jingjing Zhao^#, Qin Li^#, Yuchen Li, Xianghuo He, Qiupeng Zheng*, Shenglin Huang*. ASJA: Assembling Splice Junctions Analysis. Computational and Structural Biotechnology Journal, 2019; 17:1143-1150.
4. Yuchen Li^#, Jingjing Zhao^#, Shulin Yu, Zhen Wang, Xigan He, Yonghui Su, Tianan Guo, Haoyue Sheng, Jie Chen, Qiupeng Zheng, Yan Li, Weijie Guo, Xiaohong Cai, Guohai Shi, Jiong Wu, Lu Wang, Peng Wang*, Xianghuo He*, Shenglin Huang*. Extracellular vesicles long RNA sequencing reveals abundant mRNA, circRNA and lncRNA in human blood as biomarkers for cancer diagnosis. Clinical Chemistry，2019; 65(6):798-808.
5. Guo W^#, Hu Z^#, Bao Y, Li Y, Li S, Zheng Q, Lyu D, Chen D, Yu T, Li Y, Zhu X, Ding J, Zhao Y, He X*, Huang S*. A LIN28B Tumor-Specific Transcript in Cancer. Cell Reports, 2018; 22(8):2016-2025.
6. Shengli Li, Yuchen Li, Bing Chen, Jingjing Zhao, Shulin Yu, Yan Tang, Qiupeng Zheng, Yan Li, Peng Wang, Xianghuo He, Shenglin Huang*. exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Research, 2018; 6:D106–D112.
7. Jie Chen^#, Yan Li^#, Qiupeng Zheng, Chunyang Bao, Jian He, Bing Chen, Dongbin Lyu, Biqiang Zheng, Yu Xu, Ziwen Long, Ye Zhou, Huiyan Zhu, Yanong Wang, Xianghuo He, Yingqiang Shi*, Shenglin Huang*. Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Letters, 2017; 388: 208-19.
8. Qiupeng Zheng^#, Chunyang Bao^#, Weijie Guo, Shuyi Li, Jie Chen, Bin Chen, Yanting Luo, Dongbin Lyu, Yan Li, Guohai Shi, Linhui Liang, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nature Communications, 2016; 7:11215. DOI: 10.1038/ncomms11215.
9. Yan Li^#, Qiupeng Zheng^#, Chunyang Bao, Shuyi Li, Weijie Guo, Jiang Zhao, Di Chen, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Research, 2015; 25(8):981-4.
10. Chunyang Bao^#, Yan Li^#, Lin Huan, Yuannv Zhang, Fangyu Zhao, Qifeng Wang, Linhui Liang, Jie Ding, Li Liu, Taoyang Chen, Jinjun Li, Ming Yao, Shenglin Huang*, Xianghuo He*. NF-kB signaling relieves negative regulation by miR-194 in hepatocellular carcinoma by suppressing the transcription factor HNF-1a. Science Signaling, 2015; 8(387):ra75.
11. Zheng Q, Cai X, Tan MH, Schaffert S, Arnold CP, Gong X, Chen CZ*, Huang S*. Precise gene deletion and replacement using the CRISPR/Cas9 system in human cells. Biotechniques, 2014; 57(3):115-24.