专职PI
何祥火 研究员

研究员,博士生导师,复旦大学特聘教授

E-mail: xhhe@fudan.edu.cn
 

  1995年与1998年于华东师范大学获本科及理学硕士学位;2003年于复旦大学获理学博士学位。2003年至2006年于美国UT M.D.安德森癌症中心从事博士后研究。2006年至2013年任职于上海市肿瘤研究所癌基因及相关基因国家重点实验室,研究员,PI2014年至今任职于复旦大学生物医学研究院及复旦大学附属肿瘤医院/肿瘤研究所,研究员,博士生导师,复旦大学特聘教授。
  2011年国家杰出青年科学基金获得者、2017年入选第三批国家“万人计划”创新领军人才。曾入选科技部中青年创新领军人才、教育部新世纪优秀人才、上海市优秀学术带头人、上海市医学领军人才、上海市浦江人才、上海市教委曙光学者、上海卫生系统优秀学科带头人;曾获吴孟超医学基金奖一等奖、银蛇奖、明治生命科学奖;曾获教育部自然科学奖二等奖及上海医学科技奖二等奖。
  研究领域为肿瘤分子生物学,主要从事消化系恶性肿瘤发生与转移的分子机理研究,已发表论文120余篇,包括Nature Cell Biology, Gastroenterology, Hepatology, Cell Research, Nature Communications, Nucleic Acids Research, Cancer Research, Clinical Cancer Research等国际学术期刊;论文被引10000余次, H-index为50(至2021-12)(全部已发表论文,参考:ORCID:0000-0001-8872-668X; Web of Science ResearcherID:I-1497-2014)。


研究领域:

  肿瘤分子生物学,研究方向包括:
  1.非编码RNA功能及分子机制;
  2.RNA可变剪接异常及调控机制;
  3.转录重编程及表观调控机制。


代表性论著*为通讯作者)

  1. Ding J#, Zhao J, Huan L, Liu Y, Qiao Y, Wang Z, Chen Z, Huang S, Zhao Y*, He X*. Inflammation-Induced Long Intergenic Noncoding RNA (LINC00665) Increases Malignancy Through Activating the Double-Stranded RNA-Activated Protein Kinase/Nuclear Factor Kappa B Pathway in Hepatocellular Carcinoma. Hepatology, 2020 Nov;72(5):1666-1681.
  2. Hu Z#, Dong L#, Li S, Li Z, Qiao Y, Li Y, Ding J, Chen Z, Wu Y, Wang Z, Huang S, Gao Q*, Zhao Y*, He X*. Splicing Regulator p54 nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma. Hepatology, 2020 Aug; 72(2):548-568.
  3. Li S#, Hu Z, Zhao Y, Huang S, He X*. Transcriptome-Wide Analysis Reveals the Landscape of Aberrant Alternative Splicing Events in Liver Cancer. Hepatology, 2019 Jan; 69(1):359-375.
  4. Li Z#, Zhang J#, Liu X#, Li S, Wang Q, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q*, Zhao Y*, He X*. The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma. Nat Commun, 2018 Apr 20; 9(1):1572.
  5. Qiu Z#, Guo W#, Wang Q#, Chen Z, Huang S, Zhao F, Yao M, Zhao Y*, He X.* MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells. Gastroenterology, 2015 Nov; 49(6):1587-1598.e11.
  6. Guo W#, Qiu Z#, Wang Z#, Wang Q, Tan N, Chen T, Chen Z, Huang S, Gu J, Li J, Yao M, Zhao Y*, He X.* MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. Hepatology, 2015 Oct; 62(4):1132-44.
  7. Jia D#, Jing Y, Zhang Z, Liu L, Ding J, Zhao F, Ge C, Wang Q, Chen T, Yao M, Li J, Gu J, He X.* Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma. Cell Res, 2014 Feb; 24(2):204-17.
  8. Ding J#, Huang S#, Wang Y, Tian Q, Zha R, Shi H, Wang Q, Ge C, Chen T, Zhao Y, Liang L, Li J, He X.* Genome-wide screening reveals that miR-195 targets the TNF-α/NF-κB pathway by down-regulating IκB kinase alpha and TAB3 in hepatocellular carcinoma. Hepatology, 2013 Aug; 58(2):654-66.
  9. Jia D#, Wei L, Guo W, Zha R, Bao M, Chen Z, Zhao Y, Ge C, Zhao F, Chen T, Yao M, Li J, Wang H, Gu J, He X.* Genome-wide copy number analyses identified novel cancer genes in hepatocellular carcinoma. Hepatology, 2011 Oct; 54(4): 1227-36.
  10. Ding J#, Huang S#, Wu S, Zhao Y, Liang L, Yan M, Ge C, Yao J, Chen T, Wan D, Wang H, Gu J, Yao M, Li J, Tu H, He X.* Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nat Cell Biol, 2010 Apr; 12(4):390-9.
 
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