何祥火 研究员 研究员，博士生导师，复旦大学特聘教授 E-mail: xhhe@fudan.edu.cn

　　1995年与1998年于华东师范大学获本科及理学硕士学位；2003年于复旦大学获理学博士学位。2003年至2006年于美国UT M.D.安德森癌症中心从事博士后研究。2006年至2013年任职于上海市肿瘤研究所癌基因及相关基因国家重点实验室，研究员，PI。2014年至今任职于复旦大学生物医学研究院及复旦大学附属肿瘤医院/肿瘤研究所，研究员，博士生导师，复旦大学特聘教授。
　　2011年国家杰出青年科学基金获得者。曾入选科技部中青年创新领军人才、教育部新世纪优秀人才、上海市优秀学术带头人、上海市医学领军人才、上海市浦江人才、上海市教委曙光学者、上海卫生系统优秀学科带头人；曾获吴孟超医学基金奖一等奖、银蛇奖、明治生命科学奖；曾获教育部自然科学奖二等奖及上海医学科技奖二等奖。
　　研究领域为肿瘤分子生物学，主要从事消化系恶性肿瘤发生与转移的分子机理研究，已发表论文120余篇，包括Nature Cell Biology, Gastroenterology, Hepatology, Cell Research, Nature Communications, Nucleic Acids Research, Cancer Research, Clinical Cancer Research等国际学术期刊；论文被引10000余次, H-index为50（至2021-12）（全部已发表论文，参考：ORCID:0000-0001-8872-668X; Web of Science ResearcherID:I-1497-2014）。

研究领域：

　　肿瘤分子生物学，研究方向包括：
　　1.非编码RNA功能及分子机制；
　　2.RNA可变剪接异常及调控机制；
　　3.转录重编程及表观调控机制。

代表性论著（*为通讯作者）：

1. Ding J^#, Zhao J, Huan L, Liu Y, Qiao Y, Wang Z, Chen Z, Huang S, Zhao Y*, He X*. Inflammation-Induced Long Intergenic Noncoding RNA (LINC00665) Increases Malignancy Through Activating the Double-Stranded RNA-Activated Protein Kinase/Nuclear Factor Kappa B Pathway in Hepatocellular Carcinoma. Hepatology, 2020 Nov;72(5):1666-1681.
   
2. Hu Z^#, Dong L^#, Li S, Li Z, Qiao Y, Li Y, Ding J, Chen Z, Wu Y, Wang Z, Huang S, Gao Q*, Zhao Y*, He X*. Splicing Regulator p54 ^nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma. Hepatology, 2020 Aug; 72(2):548-568.
3. Li S^#, Hu Z, Zhao Y, Huang S, He X*. Transcriptome-Wide Analysis Reveals the Landscape of Aberrant Alternative Splicing Events in Liver Cancer. Hepatology, 2019 Jan; 69(1):359-375.
4. Li Z^#, Zhang J^#, Liu X^#, Li S, Wang Q, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q^*, Zhao Y^*, He X*. The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma. Nat Commun, 2018 Apr 20; 9(1):1572.
5. Qiu Z^#, Guo W^#, Wang Q^#, Chen Z, Huang S, Zhao F, Yao M, Zhao Y*, He X.* MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells. Gastroenterology, 2015 Nov; 49(6):1587-1598.e11.
6. Guo W^#, Qiu Z^#, Wang Z^#, Wang Q, Tan N, Chen T, Chen Z, Huang S, Gu J, Li J, Yao M, Zhao Y*, He X.* MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. Hepatology, 2015 Oct; 62(4):1132-44.
7. Jia D^#, Jing Y, Zhang Z, Liu L, Ding J, Zhao F, Ge C, Wang Q, Chen T, Yao M, Li J, Gu J, He X.* Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma. Cell Res, 2014 Feb; 24(2):204-17.
8. Ding J^#, Huang S^#, Wang Y, Tian Q, Zha R, Shi H, Wang Q, Ge C, Chen T, Zhao Y, Liang L, Li J, He X.* Genome-wide screening reveals that miR-195 targets the TNF-α/NF-κB pathway by down-regulating IκB kinase alpha and TAB3 in hepatocellular carcinoma. Hepatology, 2013 Aug; 58(2):654-66.
9. Jia D^#, Wei L, Guo W, Zha R, Bao M, Chen Z, Zhao Y, Ge C, Zhao F, Chen T, Yao M, Li J, Wang H, Gu J, He X.* Genome-wide copy number analyses identified novel cancer genes in hepatocellular carcinoma. Hepatology, 2011 Oct; 54(4): 1227-36.
10. Ding J^#, Huang S^#, Wu S, Zhao Y, Liang L, Yan M, Ge C, Yao J, Chen T, Wan D, Wang H, Gu J, Yao M, Li J, Tu H, He X.* Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nat Cell Biol, 2010 Apr; 12(4):390-9.