徐彦辉 研究员 研究员，博士生导师 E-mail: xuyh@fudan.edu.cn或xulab@foxmail.com 实验室主页：http://xulab.fudan.edu.cn

      1999年获清华大学生物科学与技术系学士学位，2004年获清华大学生物科学与技术系博士学位，2004-2008年在美国普林斯顿大学分子生物学系做博士后研究，2008-2017年，为复旦大学生物医学研究院（IBS）研究员，博士生导师，2010-2017任复旦大学附属肿瘤医院兼职教授。2017年至今任职于复旦大学附属肿瘤医院研究员，复旦大学IBS兼职教授。

      国家杰出青年科学基金获得者，长江学者特聘教授，科技部重点研发计划项目首席科学家，入选万人计划-科技创新领军人才等人才项目。作为第一完成人获2016年度教育部自然科学一等奖（DNA甲基化动态调控蛋白TET的结构生物学研究）。获得首届“中国优秀青年科技奖”、“中国优秀青年科技人才奖”、“谈家桢生命科学奖”、“树兰医学青年奖”等多个奖项。

      研究方向是真核基因转录机制，染色质结构调控，表观遗传及DNA损伤修复，肿瘤发生信号通路等关键蛋白质的结构与功能，并开展靶向药物开发。迄今以通讯作者/共同通讯作者在Nature、Cell、Molecular Cell、Cell Research、Nature Communications等杂志发表论文30余篇。

研究领域：

1、  真核生物转录机制及染色质结构调控

2、  DNA损伤修复

3、  肿瘤发生信号通路等关键蛋白质的结构与功能

研究团队：

代表性论著（*为通讯作者）：

1. Xiao J, Liu M, Qi Y, Chaban Y, Gao C, Pan B, Tian Y, Yu Z, Li J, Zhang P, Xu, Y.* Structural insights into the activation of ATM kinase. Cell research, 2019; 29(8): 683-685 .
2. Feng Y, Tian Y, Wu Z, Xu, Y.* Cryo-EM structure of human SRCAP complex. Cell research,2018; 28(11): 1121-1123.
3. Yang H*, Chen X, Liu M, Xu, Y.* The structure of mTOR complexes at a glance. Precis Cancer Med, 2018; 1:7。
4. Chen, X., Liu, M., Tian, Y., Li, J., Qi, Y., Zhao, D., Wu, Z., Huang, M., Wong, C. C. L., Wang, H. W., Wang, J., Yang, H.*, and Xu, Y.* Cryo-EM structure of human mTOR complex 2. Cell research, 2018; 28:518-528。
5. Rao Q, Liu M, Tian Y, Wu Z, Hao Y, Song L, Qin Z, Ding C, Wang HW, Wang J, Xu Y*. Cryo-EM structure of human ATR-ATRIP complex. Cell Res，2018 Feb; 28(2):143-156.
6. He XD, Gong W, Zhang JN, Nie J, Yao CF, Guo FS, Lin Y, Wu XH, Li F, Li J, Sun WC, Wang ED, An YP, Tang HR, Yan GQ, Yang PY, Wei Y, Mao YZ, Lin PC, Zhao JY, Xu Y*, Xu W*, Zhao SM*. Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations. Cell Metab, 2018 Jan 9; 27(1):151-166.
7. Yin X, Liu M, Tian Y, Wang J, Xu Y*. Cryo-EM structure of human DNA-PK holoenzyme. Cell Res, 2017 Nov; 27(11):1341-1350.
   
8. Guo, X., Wang, L., Li, J., Ding, Z., Xiao, J., Yin, X., He, S., Shi, P., Dong, L., Li, G., Tian, C., Wang, J., Cong, Y., and Xu, Y.* Structural insight into autoinhibition and histone H3-induced activation of DNMT3A. Nature, 2015 Jan 29; 517(7536):640-4. Reviewed by: Faculty of 1000
9. Hu L, Lu J, Cheng J, Rao Q, Li Z, Hou H, Lou Z, Zhang L, Li W, Gong W, Liu M, Sun C, Yin X, Li J, Tan X, Wang P, Wang Y, Fang D, Cui Q, Yang P, He C, Jiang H, Luo C*, Xu, Y.* Structural insight into substrate preference for TET-mediated oxidation. Nature, 2015 Nov 5; 527(7576):118-22.
10. Hu, L., Li, Z., Cheng, J., Rao, Q., Gong, W., Liu, M., Shi, Y. G., Zhu, J., Wang, P., and Xu, Y.* Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation. Cell, 2013 Dec 19; 155(7):1545-55.
    Reviewed by: Faculty of 1000, Nature China, Preview in Cell
11. Yang Y, Yin X, Yang H, Xu, Y.* Histone Demethylase LSD2 Acts as an E3 Ubiquitin Ligase and Inhibits Cancer Cell Growth through Promoting Proteasomal Degradation of OGT. Mol Cell, 2015 Apr 2; 58(1):47-59.
    Highlights in Science Signaling
12. Cheng J, Yang H, Fang J, Ma L, Gong R, Wang P, Li Z, Xu Y.* Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nat Commun, 2015 May 11;6:7023.
13. Fang J, Cheng J, Wang J, Zhang Q, Liu M, Gong R, Wang P, Zhang X, Feng Y, Lan W, Wong J, Yang H, Cao C, Xu, Y.* Hemi-methylated DNA Opens a Closed Conformation of UHRF1 to Facilitate Its Histone Recognition. Nat Commun, 2016 Apr 5; 7:11197.
14. Fang, R., Chen, F., Dong, Z., Hu, D., Barbera, A. J., Clark, E. A., Fang, J., Yang, Y., Mei, P., Rutenberg, M., Li, Z., Zhang, Y., Xu, Y., Yang, H., Wang, P., Simon, M. D., Zhou, Q., Li, J., Marynick, M. P., Li, X., Lu, H., Kaiser, U. B., Kingston, R. E., Xu, Y.*, and Shi, Y. G.* LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation. Molecular cell, 2013 Feb 7; 49(3):558-70.
    Reviewed by：Nature China
15. Gong, R., Li, L., Liu, Y., Wang, P., Yang, H., Wang, L., Cheng, J., Guan, K. L.*, and Xu, Y.* Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation. Genes & development, 2011 Aug 15; 25(16):1668-73.
16. Li, Z., Zhao, B., Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K. L.*, and Xu, Y.* Structural insights into the YAP and TEAD complex. Genes & development, 2010 Feb 1; 24(3):235-40.
17. Zhu, T., Roundtree, I. A., Wang, P., Wang, X., Wang, L., Sun, C., Tian, Y., Li, J., He, C., and Xu, Y.* Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine. Cell research, 2014 Dec; 24(12):1493-6.
18. Chen, F., Yang, H., Dong, Z., Fang, J., Wang, P., Zhu, T., Gong, W., Fang, R., Shi, Y. G., Li, Z.*, and Xu, Y.* Structural insight into substrate recognition by histone demethylase LSD2/KDM1b. Cell research, 2013 Feb; 23(2):306-9.
19. Ma, H., Chen, H., Guo, X., Wang, Z., Sowa, M. E., Zheng, L., Hu, S., Zeng, P., Guo, R., Diao, J., Lan, F., Harper, J. W., Shi, Y. G., Xu, Y.*, and Shi, Y.* M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. Proceedings of the National Academy of Sciences of the United States of America, 2012 Mar 27; 109(13):4828-33.
20. Hu, L., Li, Z., Wang, P., Lin, Y., and Xu, Y.* Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2. Cell research, 2011 Sep; 21(9):1374-8.
21. Yang, Y., Hu, L., Wang, P., Hou, H., Lin, Y., Liu, Y., Li, Z., Gong, R., Feng, X., Zhou, L., Zhang, W., Dong, Y., Yang, H., Lin, H., Wang, Y., Chen, C. D.*, and Xu, Y.* Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell research, 2010 Aug; 20(8):886-98. [Cover story]
    Reviewed by：Highlights in Cell Research