副研究员

侯海峰 副研究员
副研究员,博士
E-mail: Haifeng_hou@hotmail.com


  2003年获北京理工大学学士学位,2008年获中国科学院高能物理研究所博士学位,2008年-2017年在中国科学院高能物理研究所工作,历任助理研究员和副研究员,从事结构生物学研究。期间于2010-2011年前往美国西南医学中心药理系从事博士后研究。2017年7月任职于复旦大学附属肿瘤医院肿瘤研究所。主持和参加多项国家自然科学基金青年项目和面上项目,参加多项自然科学基金重点项目和973项目。研究成果发表于Nature, Cell Research, JMB, JBC等国际期刊。


研究领域:

      综合利用生物物理,生物化学的方法研究超大复合体的结构与功能。目前正在开展染色质结构调控和DNA损伤修复等方面蛋白质复合物的结构功能研究。希望揭示这些复杂生命过程的基本原理,并为靶向药物研发提供结构基础。

 

代表性论著:

  1. Li Y, Guo Z, Jin L, Wang D, Gao Z, Su X, Hou H*, Dong Y*. Mechanism of the allosteric regulation of Streptococcus mutans 2'-deoxycytidylate deaminase. Acta Crystallogr D Struct Biol, 2016 Jul; 72(Pt 7):883-91.
  2. Chen Z, Zhan LH, Hou HF, Gao ZQ, Xu JH, Dong C, Dong YH. Structural basis for the interaction of BamB with the POTRA3-4 domains of BamA. Acta Crystallogr D Struct Biol, 2016 Feb; 72(Pt 2):236-44.
  3. Hu L, Lu J, Cheng J, Rao Q, Li Z, Hou H, Lou Z, Zhang L, Li W, Gong W, Liu M, Sun C, Yin X, Li J, Tan X, Wang P, Wang Y, Fang D, Cui Q, Yang P, He C, Jiang H, Luo C, Xu Y. Structural insight into substrate preference for TET-mediated oxidation. Nature, 2015 Nov 5; 527(7576):118-22.
  4. Wang W, Hou H, Du Q, Zhang W, Liu G, Shtykova EV, Xu J, Liu P, Dong Y. Solution small angle X-ray scattering (SAXS) studies of RecQ from Deinococcus radiodurans and its complexes with junction DNA substrates. J Biol Chem, 2013 Nov8; 288 (45):32414-23.
  5. Zhang Y, Gao Z, Guo Z, Zhang H, Zhang Z, Luo M, Hou H, Huang A, Dong Y, Wang D. The crystal structure of human protein α1M reveals a chromophore-binding site and two putative protein-protein interfaces. Biochem Biophys Res Commun, 2013 Sep 27; 439 (3):346-50.
  6. Liu S, Zhang W, Gao Z, Ming Q, Hou H, Lan W, Wu H, Cao C, Dong Y.  NMR structure of the N-terminal-most HRDC1 domain of RecQ helicase from Deinococcus radiodurans. FEBS Lett, 2013 Aug 19; 587(16):2635-42.
  7. Dong C, Yang X, Hou HF, Shen YQ, Dong YH. Structure of Escherichia coli BamB and its interaction with POTRA domains of BamA. Acta Cryst D, 2012; 68:1134-9.
  8. Dong C, Hou HF, Yang X, Shen YQ, Dong YH. Structure of Escherichia coli BamD and its functional implications in outer membrane protein assembly. Acta Cryst D, 2012; 68:95-101.
  9. Zhang H, Gao ZQ, Hou HF, Xu JH, Li LF Su XD, Dong YH. High-resolution structure of a new crystal form of BamA POTRA4-5 from Escherichia Coli. Acta Cryst F, 2011; 67:734-738.
  10. Li Y, Gao Z, Hou H, Li L, Zhang J, Yang H, Dong Y, Tan H. Crystal structure and site-directed mutagenesis of a nitroalkane oxidase from Streptomyces ansochromogenes. Biochem Biophys Res Commun, 2011; 405(3): 344-8.
  11. Yang Y, Hu L, Wang P, Hou H, Lin Y, Liu Y, Li Z, Gong R, Feng X, Zhou L, Zhang W, Dong Y, Yang H, Lin H, Wang Y, Chen CD, Xu Y. Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Research2010 Aug; 20(8):886-98.
  12. Zengqiang Gao, Haifeng Hou and Yuhui Dong. Chap7. Protein Crystallography for Metalloproteins, Nuclear Analytical Techniques for Metallomics and Metalloproteomics. Royal Society of Chemistry Press,2010; 212-235.
  13. Haifeng Hou# and Hongtao Yu. Structural insights into histone lysine demethylation. Current opinion in structural biology, 2010 Dec; 20(6):739-48.
  14. C.-P. Liu, R. Xu, Z.-Q. Gao, J.-H. Xu, H.-F. Hou, L.-Q. Li, Z. She, L.-F. Li, X.-D. Su, P. Liu and Y.-H. Dong. Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans. Acta Cryst F, 2010; 66:498-502.
  15. Hai-Feng Hou#, Yu-He Liang, Lan-Fen Li, Xiao-Dong Su,and Yu-Hui Dong. Crystal Structures of Streptococcus mutans 2′-Deoxycytidylate Deaminase and Its Complex with Substrate Analog and Allosteric Regulator dCTP·Mg2+Journal of Molecular Biology, 2008; 377:220-231.
  16. GAO Zeng-Qiang, HOU Hai-Feng, LI Li-Qin, XU Rui, LIANG Yu-He, LI Lan-Fen, SU Xiao-Dong, DONG Yu-Hui. Protein Preparation, Crystallization and Preliminary X-ray Crystallographic Analysis of Smu.195c From Caries Pathogen Streptococcus mutans. Progress in Biochemistry and Biophysics, 2007; 34(2):203-206.
  17. Z.-Q. Gao, H.-F. Hou, Y.-H. Liang, L.-F. Li, X.-D. Su & Y.-H. Dong. Protein Preparation, Crystallization and Preliminary X-Ray Crystallographic studies of Smu.1392c from Streptococcus mutans. Protein and Peptide Letters, 2006; 13:1051-1052.
  18. HOU Hai-Feng#, GAO Zeng-Qiang, XU Jian-Hua, XU Rui, LI Li-Qin, LI Lan-Fen, LIANG Yu-He, SU Xiao-Dong, LIU Peng, XIAN Ding-Chang, DONG Yu-Hui. Expression, Purification, Crystallization and Preliminary X-ray Studies of a Deoxycytidylate Deaminase From Streptococcus mutans. Progress in Biochemistry and Biophysics, 2006; 33(7):673-676.
 
复旦大学肿瘤研究所 通讯地址: 东安路270号2号楼1312室 64175590-5312 Email:fuci2012@126.com
Copyright 2013 shca.org.cn All rights reserved. 复旦大学肿瘤研究所 版权所有