副研究员

秦毅 副研究员
博士,副研究员
E-mail: qinyi@fudanpci.org
 

  2003年本科毕业于吉林大学/沈阳药科大学,2011年毕业于中国科学院生物化学与细胞生物学研究所,博士学位。曾于2011年-2012年在复旦大学分子病毒实验室工作。自2012年起,一直在复旦大学肿瘤研究所/胰腺肿瘤研究所工作,2018年晋升为副研究员。主要从事胰腺癌的临床和基础研究,科研重点为胰腺癌的转化研究和胰腺癌转移机制研究等,已发表有关胰腺癌研究的SCI论著近20余篇。先后主持及参与上海科委自然科学基金,国家自然科学基金,国家杰青基金及其他省部级项目10余项。


研究领域:

  胰腺癌的转化研究和胰腺癌转移机制研究,主要研究方向如下:
  1、 驱动基因KRAS突变促进胰腺癌侵袭转移的分子机制;
  2、 抑癌基因FBW7在胰腺癌中的功能;
  3、 肿瘤代谢异常调控胰腺癌恶性潜能的分子机制。


代表性论著:

  1. Qiangsheng Hu#Yi Qin#, Jinfeng Xiang#, Wensheng Liu, Wenyan Xu, Qiqing Sun, Shunrong Ji, Jiang Liu, Zheng Zhang, Quanxing Ni, Jin Xu, Xianjun Yu*, Bo Zhang*. dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer. Cell Proliferation, 2018; Apr 27: e12456. doi: 10.1111/cpr.12456. [Epub ahead of print]
  2. Chen Liang#, Yi Qin#, Bo Zhang#, Shunrong Ji, Si Shi, Wenyan Xu,
Jiang Liu, Jinfeng Xiang, Dingkong Liang, Qiangsheng Hu, Quanxing Ni, Jin Xu, and Xianjun Yu*. Oncogenic KRAS Targets MUC16/CA125 in Pancreatic Ductal Adenocarcinoma. Molecular Cancer Research, 2017; 15(2):201-212.
  3. Qiangsheng Hu#, Yi Qin#, Bo Zhang#, Chen Liang, Shunrong Ji, Si Shi, Wenyan Xu, Jinfeng Xiang, Dingkong Liang, Quanxing Ni, Xianjun Yu*, Jin Xu*. FBW7 increases the chemosensitivity of pancreatic cancer cells to gemcitabine through upregulation of ENT1. Oncology Reports, 2017; 38(4):2069-2077.
  4. Shunrong Ji#, Yi Qin#, Chen Liang#, Run Huang, Si Shi, Jiang Liu, Kaizhou Jin, Dingkong Liang, Wenyan Xu, Bo Zhang, Liang Liu, Chen Liu, Jin Xu, Quanxing Ni, Paul J. Chiao, Min Li, and Xianjun Yu*. FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer. Clinical Cancer Research, 2016; 22(15):3950-60.
  5. Chen Liang#, Yi Qin#, Bo Zhang#, Shunrong Ji, Si Shi, Wenyan Xu, Jiang Liu, Jinfeng Xiang, Dingkong Liang, Qiangsheng Hu, Quanxing Ni, Xianjun Yu*, Jin Xu*. ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer. Cancer Letters, 2016; 388:303-311.
  6. Chen Liang#, Yi Qin#, Bo Zhang, Shunrong Ji, Si Shi, Wenyan Xu, Jiang Liu, Jinfeng Xiang, Dingkong Liang, Qiangsheng Hu, Liang Liu, Chen Liu, Guopei Luo, Quanxing Ni, Jin Xu*, and Xianjun Yu*. Energy sources identify metabolic phenotypes in pancreatic cancer. Acta Biochim Biophys Sin, 2016; 48(11):969-979.
  7. Chen Liang#, Yi Qin#, Bo Zhang, Shunrong Ji, Si Shi, Wenyan Xu, Jiang Liu, Jinfeng Xiang, Dingkong Liang, Qiangsheng Hu, Quanxing Ni, Jin Xu, Xianjun Yu*. Metabolic plasticity in heterogeneous pancreatic ductal adenocarcinoma. Biochimica et Biophysica Acta, 2016; 1866(2):177-188.
  8. B. Zhang#, J. Xu#, C. Li#, S. Shi, S. Ji, W. Xu, J. Liu, K. Jin, D. Liang, C. Liang, L. Liu, C. Liu, Y. Qin* and X. Yu*. MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer. Current Molecular Medicine, 2016; 16(4):404-11.
  9. S. Shi#, J. Xu#, B. Zhang, S. Ji, W. Xu, J. Liu, K. Jin, D. Liang, C. Liang, L. Liu, C. Liu, Y. Qin* and X. Yu*. VEGF Promotes Glycolysis in Pancreatic Cancer via HIF1α Up-Regulatio. Current Molecular Medicine,2016; 16(4):394-403.
  10. Qingguo Li#, Yi Qin# Ping Wei, Peng Lian, Yaqi Li, Ye Xu, Xinxiang Li, Dawei Li, and Sanjun Cai*. Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma, Molecular Cancer Research, 2016; 14(9):830-40.
  11. Qing-Hai Ye# ,Wen-Wei Zhu#, Ju-Bo Zhang#, Yi Qin#, Ming Lu, Guo-Ling Lin, Lei Guo, Bo Zhang, Zhen-Hai Lin, Stephanie Roessler, Marshonna Forgues,Hu-Liang Jia, Lu Lu, Xiao-Fei Zhang, Bao-Feng Lian, Lu Xie,Qiong-Zhu Dong, Zhao-You Tang,Xin Wei Wang*,and Lun-Xiu Qin*. GOLM1 Modulates EGFR/RTK Cell-Surface Recycling to Drive Hepatocellular Carcinoma Metastasis. Cancer Cell, 2016; 30(3):444-58.
  12. Shunrong Ji#, Yi Qin#, Si Shi, Xiangyuan Liu, Hongli Hu, Hu Zhou, Jing Gao, Bo Zhang, Wenyan Xu, Jiang Liu, Dingkong Liang, Liang Liu, Chen Liu, Jiang Long, Haijun Zhou, Paul J Chiao, Jin Xu, Quanxing Ni, Daming Gao, Xianjun Yu*. ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. Cell Research, 2015; 25(5):561-73.
  13. Si Shi#, Shunrong Ji#, Yi Qin#, Jin Xu, Bo Zhang, Wenyan Xu, Jiang Liu, Jiang Long, Chen Liu, Liang Liu, Quanxing Ni, Xianjun Yu*. Metabolic tumor burden is associated with major oncogenomic alterations and serum tumor markers in patients with resected pancreatic cancer. Cancer Letters, 2015; 360(2):227-33.
  14. Wantong Yao#, Shunrong Ji#, Yi Qin#, Jingxuan Yang, Jin Xu, Bo Zhang, Wenyan Xu, Jiang Liu, Si Shi, Liang Liu, Chen Liu, Jiang Long, Quanxing Ni, Min Li and Xianjun Yu*. Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis. Molecular Cancer, 2014; 13:187.
  15. Yi Qin#, Wenwei Zhu# , Wenyan Xu#, Bo Zhang, Si Shi, Shunrong Ji, Jiang Liu, Jiang Long, Chen Liu, Liang Liu , Jin Xu*, Xianjun Yu*. LSD1 sustains pancreatic cancer growth via maintaining HIF1a-dependent glycolytic process. Cancer Letters, 2014; 347(2):225-32.
  16. Yanfeng Liu#, Ju-Bo Zhang#, Yi Qin#, Wei Wang, Lili Wei, Yigang Teng, Lei Guo, Bo Zhang, Zhenhai Lin, Jing Liu, Zheng-Gang Ren, Qing-Hai Ye, and Youhua Xie*. PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating Hypoxia-Inducible Factor 1a expression and protein stability. Hepatology, 2013; 58(2):692-705.
 
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