院士工作站

王红阳 院士
院士、博士生导师

 

　　王红阳教授，女，肿瘤学、分子生物学专家。中国工程院院士，发展中国家科学院院士，教育部长江特聘教授，主任医师，博士生导师。现任国家肝癌科学中心主任、国际合作生物信号转导研究中心主任。兼任中国抗癌协会副理事长，中国医学科学院学部委员，中国医师协会精准医学专业委员会主任委员，上海市医学会副会长。
　　长期从事肿瘤的基础与临床研究，对肿瘤的炎-癌转化、信号网络调控和肝癌诊断试剂研发等有重要建树。在国际有影响的主流期刊发表SCI论文200余篇；近五年申报发明专利30项，已获授权14项（国际专利2项），主持研发的Glypican-3肝癌诊断试剂获国家食品药品监督管理总局（CFDA）批复临床应用（是我国第一个具有完全自主产权获批的肝癌诊断试剂盒）。先后主持国家和省部级重大、重点科技攻关项目十余项。 以第一完成人获首届国家科学技术进步奖创新团队奖、国家自然科学二等奖、上海市自然科学一等奖、上海医学科技一等奖等9项，获全国三八红旗手标兵、总后勤部“科技金星”、上海市“十大科技精英”和上海市“优秀学科带头人”等称号，获首届“英雄杯”中国实验医学奖、韩国爱茉莉太平洋杰出女科学家奖，巾帼创新奖和首届“五洲女医师奖” 等。曾先后荣立一等功、二等功和三等功。


研究领域：

　　长期从事肿瘤的基础与临床研究，研发的肝癌检测诊断试剂盒获得国家食品药品监督管理总局（CFDA）批准在临床推广应用，对肿瘤的炎-癌转化、信号网络调控和肝癌诊断试剂研发等有重要建树。


代表性论著：

  1. Fang G, Zhang P*, Liu J, Zhang X, Zhu X, Li R, Wang H*.Inhibition of GSK-3β activity suppresses HCC malignant phenotype by inhibiting glycolysis via activating AMPK/mTOR signaling. Cancer Lett, 2019 Oct 28; 463:11-26. （IF=6.38)
  2. Cai J, Chen L, Zhang Z, Zhang X, Lu X, Liu W, Shi G, Ge Y, Gao P, Yang Y, Ke A, Xiao L, Dong R, Zhu Y, Yang X, Wang J, Zhu T, Yang D, Huang X, Sui C, Qiu S, Shen F, Sun H, Zhou W, Zhou J, Nie J, Zeng C, Stroup EK, Zhang X, Chiu BC, Lau WY, He C, Wang H, Zhang W, Fan J. Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma.  Gut, 2019 Jul 29. [Epub ahead of print] （IF=17.1)
  3. Chen S, Cao Q, Wen W*, Wang H*.Targeted therapy for hepatocellular carcinoma: Challenges and opportunities. Cancer Lett, 2019 Sep 28; 460:1-9. （IF=6.38)
  4. Wei Y, Chen X, Liang C, Ling Y, Yang X, Ye X, Zhang H, Yang P, Cui X, Ren Y, Xin X, Li H, Wang R, Wang W, Jiang F, Liu S, Ding J, Zhang B, Li L*, Wang H*.A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma. Hepatology, 2019 May 30. doi: 10.1002/hep.30795. [Epub ahead of print] （IF= 14.079)
  5. Xiang DM, Sun W, Zhou T, Zhang C, Cheng Z, Li SC, Jiang W, Wang R, Fu G, Cui X, Hou G, Jin GZ, Li H, Hou C, Liu H, Wang H*, Ding J*.Oncofetal HLF transactivates c-Jun to promote hepatocellular carcinoma development and sorafenib resistance. Gut, 2019 Oct; 68(10):1858-1871. （IF=17.1)
  6. Cheng Z, He Z, Cai Y, Zhang C, Fu G, Li H, Sun W, Liu C, Cui X, Ning B, Xiang D, Zhou T, Li X, Xie W*, Wang H*, Ding J*. Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors. Cell Res, 2019 Feb; 29(2):124-135. （IF=15.4 )
  7. Chen X, Zhuang C, Ren Y, Zhang H, Qin X, Hu L, Fu J, Miao Z, Chai Y, Liu ZG, Zhang H, Cai Z*, Wang HY*. Identification of TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3.  Br J Pharmacol, 2019 Jun; 176(12):2095-2108.
  8. Liu J, Jiang J, Mo J, Liu D, Cao D, Wang H, He Y, Wang H*. Global DNA 5-hydroxymethylcytosine and 5-formylcytosine contents are decreased in the early stage of hepatocellular carcinoma. Hepatology, 2019 Jan; 69(1):196-208（IF= 14.079)
  9. Qin X, Ma D, Tan YX, Wang HY, Cai Z. The role of necroptosis in cancer: A double-edged sword?  Biochim Biophys Acta Rev Cancer, 2019 Apr; 1871(2):259-266.
  10. Ou-Yang Q, Lin XM, Zhu YJ, Zheng B, Li L, Yang YC, Hou GJ, Chen X, Luo GJ, Huo F, Leng QB, Gonzalez FJ, Jiang XQ*, Wang HY*, Chen L*. Distinct Role of Nuclear Receptor Corepressor 1 Regulated de novo Fatty Acids Synthesis in Liver Regeneration and Hepatocarcinogenesis. Hepatology, 2018 Mar; 67(3):1071-1087.（IF=11.711)
  11. Fu J, Wang H*. Precision Diagnosis and Treatment of liver cancer in China. Cancer Lett, 2018 Jan 1; 412:283-288（IF=6.38）
  12. Wang B, Fu J, Yu T, Xu A, Qin W, Yang Z, Chen Y*, Wang H*. Contradictory Effects of Mitochondria- and Non-mitochondria-targeted Antioxidants on Hepatocarcinogenesis by Altering DNA Repair. Hepatology, 2017 Sep 12. doi: 10.1002/hep.29518. （IF=11.711）
  13. Xiang DM, Sun W, Ning BF, Zhou TF, Li XF, Zhong W, Cheng Z, Xia MY, Wang X, Deng X, Wang W, Li HY, Cui XL, Li SC, Wu B, Xie WF, Wang HY*, Ding J*. The HLF/IL-6/STAT3 Feedforward Circuit Drives Hepatic Stellate Cell Activation to Promote Liver Fibrosis. GUT, 2017 Jul 28. pii: gutjnl-2016-313392.（IF=16.60）
  14. Li XF, Chen C, Xiang DM, Qu L, Sun W, Lu XY, Zhou TF, Chen SZ, Ning BF, Cheng Z, Xia MY, Shen WF, Yang W, Wen W, Lee TKW, Cong WM, Wang HY*, Ding J*. Chronic Inflammation-elicited Liver Progenitor Cell Conversion to Liver Cancer Stem Cell with Clinical Significance. Hepatology, 2017; 66(6):1934-1951.（IF=11.711）
  15. Xi-Meng Lin, Liang Hu, Jin Gu, Ruo-Yu Wang, Liang Li, Jing Tang, Bao-Hua Zhang, Xing-Zhou Yan, Yan-Jing Zhu, Cong-Li Hu, Wei-Ping Zhou, Frank J Gonzalez, Meng-Chao Wu, Hong-Yang Wang*, and Lei Chen*. Choline Kinase Alpha-Driven Assembly of EGFR and mTORC2 Promotes Hepatocellular Carcinoma Metastasis and Drug Resistance. Gastroenterology, 2017 Apr 1; 152:1187-1202.（IF=18.187）
  16. Wang C, Lv H, Yang W, Li T, Fang T, Lv G, Han Q, Dong L, Jiang T, Jiang B, Yang G*, Wang H*. SVCT-2 determines the sensitivity to ascorbate-induced cell death in cholangiocarcinoma cell lines and patient derived xenografts. Cancer Lett, 2017 Jul 10; 398:1-11.（IF=6.375）
  17. Wu H, Zhou X, Fu GB, He ZY, Wu HP, You P, Ashton C, Wang X, Wang HY*, Yan HX*. Reversible transition between hepatocytes and liver progenitors for in vitro hepatocyte expansion. Cell Res, 2017 May; 27(5):709-712.（IF=15.606）
  18. Ke S, Chen S, Dong Z, Hong CS, Zhang Q, Tang L, Yang P, Zhai J, Yan H, Shen F, Zhuang Z, Wen W*,Wang H*. Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology, 2017 Jan; 65(1):134-151.（IF=11.055）
  19. Xiang D, Cheng Z, Liu H, Wang X, Han T, Sun W, Li X, Yang W, Chen C, Xia M, Liu N, Yin S, Jin G, Lee T, Dong L, Hu H, Wang H*, Ding J*.Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients. Hepatology, 2017 May; 65(5):1566-1580（IF=11.055）
  20. Hou G, Chen L, Liu G, Li L, Yang Y, Yan HX, Zhang HL, Tang J, Yang YC, Lin X, Chen X, Luo GJ, Zhu Y, Tang S, Zhang J, Liu H, Gu Q, Zhao LH, Li Y, Liu L*, Zhou W*, Wang H*. Aldehyde Dehydrogenase-2 (ALDH2) Opposes HCC Progression By Regulating AMPK Signaling. Hepatology, 2017 May; 65(5):1628-1644（IF=11.055）
  21. Yun-Han Ma, Wei-Tao Dou, Yu-Fei Pan, Li-Wei Dong, Ye-Xiong Tan, Xiao-Peng He,* He Tian, and Hong-Yang Wang*. Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues. Adv Mater, 2017 Feb; 29(5). doi: 10.1002/adma.201604253. Epub 2016 Nov 21. （IF=18.96）
  22. Qu L, Ding J, Chen C, Wu ZJ, Liu B, Gao Y, Chen W, Liu F, Sun W, Li XF, Wang X, Wang Y, Xu ZY, Gao L, Yang Q, Xu B, Li YM, Fang ZY, Xu ZP, Bao Y, Wu DS, Miao X, Sun HY, Sun YH, Wang HY*, Wang LH. Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Cancer Cell, 2016 May 9; 29(5):653-68. (IF= 23.214)
  23. Luo T, Fu J, Xu A, Su B, Ren Y, Li N, Zhu J, Zhao X, Dai R, Cao J, Wang B, Qin W, Jiang J, Li J, Wu M, Feng G, Chen Y*, Wang H*. PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression. Autophagy, 2016 Aug 2; 12(8):1355-71.（IF=8.593）
  24. Ling-Hao Zhao, Xiao Liu, He-Xin Yan, Wei-Yang Li, Xi Zeng, Yuan Yang, Jie Zhao,Shi-Ping Liu, Xue-Han Zhuang, Chuan Lin, Chen-Jie Qin, Yi Zhao, Ze-Ya Pan, Gang Huang, Hui Liu,Jin Zhang, Ruo-Yu Wang, Yun Yang, Wen Wen, Gui-Shuai Lv, Hui-Lu Zhang, Han Wu, Shuai Huang,Ming-Da Wang, Liang Tang, Hong-Zhi Cao, Ling Wang, Tin-Lap Lee, Hui Jiang, Ye-Xiong Tan,Sheng-Xian Yuan, Guo-Jun Hou, Qi-Fei Tao, Qin-Guo Xu, Xiu-Qing Zhang, Meng-Chao Wu, Xun Xu,Jun Wang, Huan-Ming Yang, Wei-Ping Zhou & Hong-Yang Wang* . Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun, 2016 Oct 5; 7:12992.（IF=11.47）
  25. Wu FQ, Fang T, Yu LX, Lv GS, Lv HW, Liang D, Li T, Wang CZ, Tan YX, Ding J, Chen Y, Tang L, Guo LN, Tang SH, Yang W, Wang HY*, ADRB2 signaling promotes HCC progression and sorafenib resistance by inhibiting autophagic degradation of HIF1α. J Hepatol, 2016 Aug; 65(2):314-24. (IF= 10.59)
  26. Yang C, Tan YX, Yang GZ, Zhang J, Pan YF, Liu C, Fu J, Chen Y, Ding ZW, Dong LW, Wang HY*.Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.J Exp Med, 2016 May 2; 213(5):859-75. doi: 10.1084/jem.20151208. Epub 2016 Apr 18 (IF= 11.24)
  27. Wang X, Sun W, Shen W, Xia M, Chen C, Xiang D, Ning B, Cui X, Li H, Li X, Ding J, Wang H*. Long Non-coding RNA DILC Represses Self-renewal of Liver Cancer Stem Cells via Inhibiting Autocrine IL-6/STAT3 Axis. J Hepatol, 2016 Jun; 64(6):1283-94. (IF=10.59)
  28. Wang MD, Wu H, Fu GB, Zhang HL, Zhou X, Tang L, Dong LW1, Qin CJ, Huang S, Zhao LH, Zeng M, Wu MC, Yan HX, Wang HY*. Acetyl-CoA carboxylase a promotion of glucose-mediated fatty acid synthesis enhances survival of HCC in mice and patients. Hepatology, 2016 Apr; 63(4):1272-86. (IF=11.711)
  29. Ann M.Bode, Zigang Dong*, Hongyang Wang*. Cancer prevention and control:alarming challenges in China. National Science Review, 2016; 3:117-127. (IF=8.0)
  30. Wang H*. Cancer Letters special issue hepatobiliary cancer featuring the guest editor. Cancer Lett, 2016 Sep 1; 379(2):163. (IF=5.992)
  31. Li L, Chen J, Chen X, Tang J, Guo H, Wang X, Qian J, Luo G, He F, Lu X, Ding Y, Yang Y, Huang W, Hou G, Lin X, Ouyang Q, Li H, Wang R, Jiang F, Pu R, Lu J, Jin M, Tan Y, Gonzalez FJ, Cao G, Wu M, Wen H, Wu T, Jin L, Chen L*, Wang H*. Serum miRNAs as predictive and preventive biomarker for pre-clinical hepatocellular carcinoma. Cancer Lett, 2016 Apr 10; 373(2):234-40. (IF= 5.992)
  32. Yang Y, Lin X, Lu X, Luo G, Zeng T, Tang J, Jiang F, Li L, Cui X, Huang W, Hou G, Chen X, Ouyang Q, Tang S, Sun H, Chen L, Gonzalez FJ, Wu M, Cong W, Chen L*, Wang H*. Interferon-microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis. Gut, 2016 Jul; 65(7):1186-201. (IF=14.921)
  33. Luo ZL, Cheng SQ, Shi J, Zhang HL, Zhang CZ, Chen HY, Qiu BJ, Tang L, Hu CL, Wang HY*, Li Z*.A splicing variant of Merlin promotes metastasis in hepatocellular carcinoma. Nat Commun, 2015 Oct 7; 6:8457. (IF= 11.47)
  34. Han T, Xiang DM, Sun W, Liu N, Sun HL, Wen W, Shen WF, Wang RY, Chen C, Wang X, Cheng Z, Li HY, Wu MC, Cong WM, Feng GS, Ding J*, Wang HY*. 6PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients. J Hepatol, 2015 Sep; 63(3):651-60. (IF=11.336)
  35. Jiang F, Chen L, Yang YC, Wang XM, Wang RY, Li L, Wen W, Chang YX, Chen CY, Tang J, Liu GM, Huang WT, Xu L*, Wang HY*. CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling. Cancer Res, 2015 Apr 1; 75(7):1470-81. (IF=9.329)
  36. Su B, Luo T, Zhu J, Fu J, Zhao X, Chen L, Zhang H, Ren Y, Yu L, Yang X, Wu M, Feng G, Li S, Chen Y*, Wang H*. Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis. Hepatology, 2015 Feb; 61(2):585-97. (IF=11.055)
  37. J Zhang, Y-F Pan, Z-W Ding, G-Z Yang, Y-X Tan, C Yang, T-Y Jiang, L-J Liu, B Zhang, T Han, D Cao, T Yang, N Yang, M-C Wu, L-W Dong* and H-Y Wang*. RMP promotes venous metastases of hepatocellular carcinoma through promoting IL-6 transcription. Oncogene, 2015 Mar 19; 34(12):1575-83. (IF=8.459)
  38. Liang Li, Jing Tang, Baohua Zhang, Wen Yang, Miyang LiuGao, Ruoyu Wang, Yexiong Tan, Jianling Fan, Yanxin Chang, Jing Fu, Feng Jiang, Caiyang Chen, Yingcheng Yang, Jin Gu, Dingming Wu, Linna Guo, Dan Cao, Hengyu Li, Guangwen Cao, Mengchao Wu, Michael.Q Zhang, Lei Chen* and Hongyang Wang*. Epigenetic Modification of MiR-429 Promotes Liver Tumor-Initiating Cells Properties by Targeting Rb Binding Protein 4. GUT , 2015 Jan; 64(1):156-67. (IF=14.66)
  39. Wang FS*, Fan JG, Zhang Z, Gao B, Wang HY*. The Global Burden of Liver Disease: The Major Impact of China. Hepatology, 2014 Dec; 60(6):2099-108. (IF=11.19)
  40. Le-Xing Yu, Lei Yan, Wen Yang, Fu-Quan Wu, Yan Ling, Shu-Zhen Chen, Liang Tang,Ye-Xiong Tan, Dan Cao, Meng-Chao Wu, He-Xin Yan *& Hong-Yang Wang*. Platelets promote tumour metastasis via Q1 interaction between TLR4 and tumour cell-released high-mobility group box1 protein. Nature Communications, 2014 Oct 28; 5:5256. (IF=10.742)
  41. 王红阳主编;细胞信号转导(基础理论与实用技术);上海科技教育出版社; 第1版 (2013年12月1日)
  42. RuoYu Wang, Lei Chen, HaiYang Chen, Liang Li, HanYong Sun, Feng Jiang, GaoMinyang Liu, Jing Tang, CaiYang Chen, YingCheng Yang, YanXin Chang, Hui Liu, Jin Zhang, Yuan Yang, MengChao Wu, Feng Shen, WeiPing Zhou, and HongYang Wang*. MUC15 Inhibits Dimerization of EGFR and PI3K–AKT Signaling and Is Associated with Aggressive Hepatocellular Carcinomas in Patients. Gastroenterology, 2013 Dec; 145(6):1436-1448. (IF=12.821)
  43. Chang Y, Liu C, Yang J, Liu G, Feng F, Tang J, Hu L, Li L, Jiang F, Chen C, Wang R, Yang Y, Jiang X, Wu M, Chen L, Wang H*.miR-20a triggers metastasis of gallbladder carcinoma. J Hepatol, 2013 Sep; 59(3):518-527. (IF=9.858)
  44. Haiyang Chen, Zaili Luo, Wen Sun, Cunzhen Zhang, Huanlin Sun, Nanjie Zhao, Jin Ding, Mengchao Wu, Zhong Li*, Hongyang Wang*. Low glucose promotes CD133mAb-elicited cell death via inhibition of autophagy in hepatocarcinoma cells. Cancer Letters, 2013 Aug 9; 336(1):204-212. (IF=4.258)
  45. Pan YF, Tan YX, Wang M, Zhang J, Zhang B, Yang C, Ding ZW, Dong LW*, Wang HY*.Signal regulatory protein α is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression. Hepatology, 2013 Aug; 58(2):680-691. (IF=12.003)
  46. Tang L, Tan YX, Jiang BG, Pan YF, Li SX, Yang GZ, Wang M, Wang Q, Zhang J, Zhou WP, Dong LW*, Wang HY*.The prognostic significance and therapeutic potential of hedgehog signaling in intrahepatic cholangiocellular carcinoma. Clin Cancer Res, 2013 Apr 15; 19(8):2014-2024. (IF=7.837)
  47. 王红阳参编.《中国医学科技发展报告2012》中国医学科学院编著. 北京：科学出版社，2012.
  48. 王红阳，文文参编第四章；王红阳，何雅琴，杨文参编第六章。原发性肝癌：挑战与展望= Primary Liver Cancer :Challenges and Perspectives / 顾健人主编，杭州：浙江大学出版社，2012.04.
  49. Yang W, Wang C, Lin Y, Liu Q, Yu LX, Tang L, Yan HX, Fu J, Chen Y, Zhang HL, Tang L, Zheng LY, He YQ, Li YQ, Wu FQ, Zou SS, Li Z, Wu MC, Feng GS, Wang HY*. OV6⁺tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma. J. Hepatol, 2012 Sep; 57(3):613-620. (IF=9.334)
  50. HuiLu Zhang, LeXing Yu, Wen Yang, Liang Tang, Yan Lin, Han Wu, Bo Zhai, YeXiong Tan, Lei Shan, Qiong Liu, HaiYang Chen, RongYang Dai, BiJun Qiu, YaQin He, Chao Wang, LongYi Zheng, YuQiong Li, FuQuan Wu, Zhong Li, HeXin Yan*, HongYang Wang*. Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. Journal of Hepatology, 2012 Oct; 57(4):803-812. (IF=9.334)
  51. Wu K, Ding J, Chen C, Sun W, Ning BF, Wen W, Huang L, Han T, Yang W, Wang C, Li Z, Wu MC, Feng GS, Xie WF, Wang HY*.Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. Hepatology, 2012 Dec; 56(6):2255-2267. (IF=10.885)
  52. Wen W, Jin Ding, Wen Sun, Jing Fu, Yao Chen, Kun Wu, Beifang Ning, Tao Han, Lei Huang, Cheng Chen, Dong Xie, Zhong Li,Gensheng Feng, Mengchao Wu, Weifen Xie, and Hongyang Wang*. Cyclin G1-mediated Epithelial-mesenchymal Transition via PI3-K/Akt Signaling Facilitates Liver Cancer Progression. Hepatology, 2012 Jun; 55(6):1787-1798. (IF=10.885)
  53. Qian YW, Chen Y, Yang W, Fu J, Cao J, Ren YB, Zhu JJ, Su B, Luo T, Zhao XF, Dai RY, Li JJ, Sun W, Wu MC, Feng GS, Wang HY*. p28GANK Prevents Degradation of Oct4 and Promotes Expansion of Tumor-Initiating Cells in Hepatocarcinogenesis. Gastroenterology, 2012 Jun; 142(7):1547-1558. (IF=12.032)
  54. Yexiong Tan, Peiyuan Yin, Liang Tang, Wenbin Xing, Qiang Huang, Dan Cao, Xinjie Zhao, Wenzhao Wang, Xin Lu, Zhiliang Xu, Hongyang Wang* and Guowang Xu*. Metabolomics study of stepwise hepatocarcinogenesis from the model rats to patients: potential biomarkers effective for small hepatocellular carcinoma diagnosis. Mol. Cell. Proteomics, 2012 Feb; 11(2):M111.010694. (IF=8.354)
  55. Chao Wang, Wen Yang, Hexin Yan, Tao Luo, Jian Zhang, Liang Tang,Fuquan Wu,Huilu Zhang, Lexing Yu, Longyi Zheng, Yuqiong Li,Wei Dong, Yaqin He, Qiong Liu,Shanshan Zou, Yan Lin, Liang Hu, Zhong Li, Mengchao Wu and Hongyang Wang*. HBx Induces Tumorigenicity of Hepatic Progenitor Cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) Treated HBx Transgenic Mice. Hepatology, 2012 Jan; 55(1):108-120. (IF=10.885)
  56. Liwei Dong, Yujie Hou, Yexiong Tan, Liang Tang, Yufei Pan, Min Wang and Hongyang Wang*. Prognostic significance of Beclin 1 in intrahepatic cholangiocellular carcinoma. Autophagy, 2011 Oct; 7(10):1222-1229. (IF=6.643)
  57. Liang Li, Lei Chen, Liang Hu, Yuan Liu, Hanyong Sun, Jing Tang, Yujie Hou, Yanxin Chang, Qianqian Tu, Gensheng Feng, Feng Shen, Mengchao Wu and Hongyang Wang*. The nuclear factor High-mobility group box1 mediating the activation of TLR4 signaling in hepatocytes in the early stage of NAFLD in mice. Hepatology, 2011 Nov; 54(5):1620-1630. (IF=10.885)
  58. Wen Sun, Jin Ding, Kun Wu, Beifang Ning, Wen Wen, Hanyong Sun, Tao Han,Lei Huang, Liwei Dong, Wen Yang, Xing Deng, Zhong Li, Mengchao Wu, Gensheng Feng, Weifen Xie, and Hongyang Wang*. Gankyrin-mediated Dedifferentiation Facilitates the Tumorigenicity of Hepatocytes and Hepatoma cells. Hepatology, 2011 Oct; 54(4):1259-1272. (IF=10.885)
  59. Jing Fu, Yao Chen, Jie Cao, Tao Luo, Youwen Qian, Wen Yang, Yibin Ren, Bo Su, Guangwen Cao, Yuan Yang, Yiqun Yan, Feng Shen, Mengchao Wu, Gensheng Feng and Hongyang Wang*. p28GANK Overexpression Accelerates Hepatocelluar Carcinoma Invasiveness and Metastasis via PI3K/AKT/HIF-1α Pathways. Hepatology, 2011 Jan; 53(1):181-192. (IF=10.885)
  60. Liang Hu, Lei Chen, Liang Li, Hanyong Sun, Guangzhen Yang, Yanxin Chang, Qianqian Tu, Mengchao Wu, and Hongyang Wang*. Hepatitis B Virus X Protein Enhances Cisplatin-Induced Hepatotoxicity via a Mechanism Involving Degradation of Mcl-1. J. Virol, 2011 Apr; 85(7):3214-3228. (IF=5.189)
  61. Hanyong Sun, Lei Chen, Weiping Zhou, Liang Hu, Liang Li, Yanxin Chang, Qianqian Tu, Qu Liu, Xuejun Sun, Mengchao Wu, Hongyang Wang*. The Protective Role of Hydrogen-Rich Saline in Experimental Liver Injury in Mice. J. Hepatol, 2011 Mar; 54(3):471-480. (IF=9.334)
  62. Liwei Dong, Guangzhen Yang, Yufei Pan, Yao Chen, Yexiong Tan, Rongyang Dai, Yibin Ren, Jing Fu, Hongyang Wang*. The oncoprotein p28GANK establishes a positive feedback loop in β-catenin signaling. Cell Res, 2011 Aug; 21(8):1248-1261. (IF=9.417)
  63. Lexing Yu, Hexin Yan, Qiong Liu, Wen Yang, Hongping Wu, Wei Dong, Liang Tang, Yan Lin,Yaqin He, Shanshan Zou, Chao Wang, Huilu Zhang, Guangwen Cao, Mengchao Wu, and Hongyang Wang*. Endotoxin Accumulation Prevents Carcinogen-Induced Apoptosis and Promotes Liver Tumorigenesis in Rodents. Hepatology, 2010 Oct; 52(4):1322-1333. (IF=10.885)
  64. Beifang Ning, Jin Ding, Chuan Yin, Wei Zhong, Kun Wu, Xin Zeng, Wen Yang, Yuexiang Chen,Junping Zhang, Xin Zhang, Hongyang Wang* and Weifen Xie*. Hepatocyte nuclear factor 4 alpha suppresses the development of hepatocellular carcinoma. Cancer Res, 2010 Oct 1; 70(19):7640-7651. (IF=8.234)
  65. Wen W, Ding J, Sun W, Wu K, Ning BF, Gong WF, He GP, Huang SN, Ding XY, Yin PP, Chen L, Liu Q, Xie WF, Wang HY*. Suppression of Cyclin D1 by Hypoxia-Inducible Factor-1 via Direct Mechanism Inhibits the Proliferation and 5-Fluorouracil-induced apoptosis of A549 Cells. Cancer Res, 2010 Mar 1; 70(5):2010-2019. (IF=8.234)
  66. Liu Q, Zhai B, Yang W, Yu LX, Dong W, He YQ, Chen L, Tang L, Lin Y, Huang DD, Wu HP, Wu MC, Yan HX*, Wang HY*. Abrogation of Local Cancer Recurrence after Radiofrequency Ablation by Dendritic Cell-based Hyperthermic Tumor Vaccine. Mol. Ther, 2009 Dec; 17(12):2049-2057. (IF=7.149)
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  68. Rongyang Dai, Yao Chen, Jing Fu, Liwei Dong, Yibin Ren, Guangzhen Yang, Youwen Qian, Jie Cao, Shanhua Tang, Shengli Yang, Hongyang Wang*. p28GANK inhibits endoplasmic reticulum stress-induced cell death via enhancement of the endoplasmic reticulum adaptive capacity. Cell Res, 2009 Nov; 19(11):1243-1257. (IF=9.417)
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