陈磊 研究员 研究员

　　2002年本科毕业于复旦大学生命科学院，2007年研究生毕业于海军军医大学。2015-2016在美国国立卫生研究院国家癌症研究所访问学者。2017年9月起任肿瘤研究所王红阳院士工作站PI。2017年获教育部青年长江学者，2015年获国家基金委优秀青年科学基金，2015年所在集体获军队一等功，2014年获上海市青年科技英才（成果转化类）和明治生命科学奖（二等奖），2013年获第二军医大学“优秀青年学者”，2012年获军队个人三等功，2008年获上海市医学科技一等奖（第三完成人）。兼任中国医师协会临床精准医疗专业委员会常务委员，上海医学会分子诊断专委会青年委员会副主任委员，上海市遗传学会理事。主要研究方向为肝脏恶性肿瘤早期预警和个体化诊疗。先后在Gastroenterology，Nature Communications，Gut，Cancer Research， Hepatology, Journal of Hepatology，BBA-reviews on Cancer，Nature Cell Biology，J.E.M，Gene & Development等学术期刊发表SCI论文50余篇，总引用次数2120次。发表第一作者/通讯作者SCI研究论文30篇，其中影响因子大于10分论文12篇。获国家发明专利授权3项，申报国家发明专利6项。

研究领域：

　　1. 肝胆肿瘤早期预警标志物筛选、鉴定；
　　2. 肝胆肿瘤早期发生分子机制；
　　3. 肿瘤个体化治疗分子机理及干预策略。

代表性论著：

1. Jiabin Cai^#, Lei Chen^#, Zhou Zhang^#, Xinyu Zhang^#, Xingyu Lu, Weiwei Liu, Guoming Shi, Yang Ge, Pingting Gao, Yuan Yang, Aiwu Ke, Linlin Xiao, Ruizhao Dong, Yanjing Zhu, Xuan Yang, Jiefei Wang, Tongyu Zhu, Deping Yang, Xiaowu Huang, Chengjun Sui, Shuangjian Qiu, Feng Shen, Huichuan Sun, Weiping Zhou, Jian Zhou, Ji Nie, Chang Zeng, Emily Kunce Stroup, Xu Zhang, Brian C-H Chiu, Wan Yee Lau, Chuan He*, Hongyang Wang*, Wei Zhang*, Jia Fan*. Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma. Gut, 2019; 0:1–11. doi:10.1136/gutjnl-2019-318882.
2. Seogsong Jeon, Bo Zheng, Hongyang Wang*, Qiang Xia*, Lei Chen*. Nervous system and primary liver cancer. BBA-Reviews on Cancer, 2018 DOI:10.1016/j.bbcan.2018.04.002. (Review Article)
3. Xi-Meng Lin#, Liang Hu#, Jin Gu#, Ruo-Yu Wang#, Liang Li, Jing Tang, Bao-Hua Zhang, Xing-Zhou Yan, Yan-Jing Zhu, Cong-Li Hu, Wei-Ping Zhou, Frank J Gonzalez, Meng-Chao Wu, Hong-Yang Wang*, and Lei Chen*. Choline Kinase Alpha-Driven Assembly of EGFR and mTORC2 Promotes Hepatocellular Carcinoma Metastasis and Drug Resistance. Gastroenterology, 2017 Apr 1; 152:1187-1202.
4. RuoYu Wang#, Lei Chen#, HaiYang Chen#, Liang Hu, Liang Li, HanYong Sun, Feng Jiang, GaoMinyang Liu, Jing Tang, CaiYang Chen, YingCheng Yang, YanXin Chang, Hui Liu, Jin Zhang, Yuan Yang, MengChao Wu, Feng Shen, WeiPing Zhou*, and HongYang Wang*. MUC15 Inhibits Dimerization of EGFR and PI3K–AKT Signaling and Is Associated with Aggressive Hepatocellular Carcinomas in Patients. Gastroenterology, 2013 Dec; 145(6):1436-48.
5. Yingcheng Yang#, Ximeng Lin#, Xinyuan Lu#, Guijuan Luo#, Tao Zeng, Jing Tang, Feng Jiang, Liang Li, Xiuliang Cui, Wentao Huang,Guojun Hou, Xin Chen, Qing Ouyang, Shanhua Tang,Huanlin Sun,Luonan Chen,Mengchao Wu,Frank J. Gonzalez,Wenming Cong, Lei Chen*, Hongyang Wang*. Interferon-MicroRNA Signaling Drives Liver Precancerous Lesion Formation and Hepatocarcinogenesis. Gut, 2016 Jul;65(7):1186-201.
6. Liang Li#, Jing Tang#, Baohua Zhang#, Wen Yang, Haiyang Chen, Miyang Liu Gao, Ruoyu Wang, Yexiong Tan, Jianling Fan, Yanxin Chang, Jing Fu, Feng Jiang, Caiyang Chen, Yingcheng Yang, Dingming Wu, Ruiying Zheng, Hengyu Li, Baohua Zhang, Mengchao Wu, Michael.Q Zhang, Lei Chen* and Hongyang Wang*. Epigenetic Modification of miR-429 in Hepatocellular Carcinoma Manipulates EpCAM+ Liver Tumor-Initiating Cells Properties via Targeting RBBP4/E2F1/Oct4 Axis. Gut, 2015; 64:1156-167.
7. Yang Yang#, Lei Chen#, Jin Gu#, Hanshuo Zhang#, Jiapei Yuan, Qiuyu Lian, Guishuai, Siqi Wang, Yang Wu, Yu-Cheng T. Yang, Dongfang Wang, Yang Liu, Jing Tang, Guijuan Luo, Yang Li, Long Hu, Xinbao Sun, Dong Wang, Mingzhou Guo, Qiaoran Xi, Jianzhong Xi, Hongyang Wang*, Michael Q. Zhang*, and Zhi John Lu*. Recurrently deregulated lncRNAs in hepatocellular carcinoma. Nature Communication, 2017 Feb 13; 8:14421.
8. Qing Ou-Yang#, Xi-Meng Lin#, Yan-Jing Zhu#, Bo Zheng#, Liang Li, Ying-Cheng Yang, Guo-Jun Hou, Xin Chen, Gui-Juan Luo, Feng Huo, Qi-Bin Leng, Frank J Gonzalez, Xiao-Qing Jiang*, Hong-Yang Wang*, and Lei Chen*. Distinct Role of Nuclear Receptor Corepressor 1 Regulated de novo Fatty Acids Synthesisin Liver Regenerationand Hepatocarcinogenesis. Hepatology, 2017 March; 67(3):1071-1087.
9. Guojun Hou#, Lei Chen#, Gang Liu#, Liang Li, Yuan Yang, He-Xin Yan, Hui-Lu Zhang, Jing Tang, Ying Cheng Yang, Ximeng Lin, Xin Chen, Gui juan Luo, Yanjing Zhu, Shanhua Tang, Jin Zhang, Hui Liu, Qingyang Gu, Ling-Hao Zhao, Yixue Li, Lei Liu, Weiping Zhou*, Hongyang Wang*. Aldehyde Dehydrogenase-2 (ALDH2) Opposes HCC Progression by Regulating AMPK Signaling. Hepatology, 2017 May; 65(5):1628-1644.
10. Feng Jiang#, Lei Chen#, Ying-Cheng Yang#, Xian-Ming wang, Ruo-Yu Wang, Liang Li, Wen Wen, Yan-Xin Chang, Cai-Yang Chen, Jing Tang, Gao-Mi-Yang Liu, Wen-Tao Huang, Lin Xu*, and Hong-Yang Wang*. CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signalin. Cancer Research, 2015 Apr 1; 75(7):1470-81.
11. Yanxin Chang#, Chen Liu#, Jiahe Yang#, Gaomiyang Liu, Feiling Feng,Jing Tang, Liang Hu, Liang Li, Feng Jiang, Caiyang Chen, Ruoyu Wang, Yingcheng Yang, Xiaoqing Jiang, Mengchao Wu, Lei Chen* and Hongyang Wang*. MiR-20a Triggers Metastasis of Gallbladder Carcinoma. Journal of Hepatology, 2013 Sep; 59(3):518-27.