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2011年毕业于上海交通大学医学院,获生物化学与分子生物学博士学位。毕业后任职于复旦大学附属肿瘤医院肿瘤研究所,乳腺癌研究所。期间于2016-2017年前往美国斯坦福大学医学院访问交流。主持和参加多项国家自然科学基金青年项目和面上项目,参加国家科技支撑计划、上海市科委基础研究项目等。研究成果发表于Nat Communication、The EMBO journal等国际核心杂志。
研究领域:
1.乳腺癌相关通路分子异常剪接与乳腺癌转移的关系;
2.乳腺癌相关通路分子异常表达及突变与乳腺癌发生发展的关系。
代表性论著:
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Yao L#, Liu Y#, Cao Z, Li J, Huang Y,
Hu X, Shao Z*. MicroRNA 493 is a prognostic factor in
triple-negative breast cancer. Cancer Sci., 2018 Jul; 109(7):2294-2301.
Src
and transformation by an RPTPalpha splice mutant found in human tumours. The
EMBO journal., 2011; 30(15):3200-3211.
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Chen L#, Yang L#, Yao L#, Kuang XY, Zuo WJ, Li S, Qiao F, Liu YR, Cao ZG,
Zhou SL, Zhou XY, Yang WT, Shi JX, Huang W, Hu X, Shao ZM*.
Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast
cancer patients. Nat Commun., 2018 Apr 10; 9(1):1357.
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Yao L#, Chi Y#, Hu X#, Li S, Qiao F, Wu J, Shao ZM*.
Elevated expression of RNA methyltransferase BCDIN3D predicts poor prognosis in
breast cancer. Oncotarget, 2016 Aug 16; 7(33):53895-53902.
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Cao
ZG#, Huang YN#, Yao L#,
Liu YR, Hu X, Hou YF, Shao ZM*. Positive expression of miR-361-5p
indicates better prognosis for breast cancer patients. J Thorac Dis., 2016
Jul; 8(7):1772-9.
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Chi
Y#, Yao L#,
Hu X, Huang S, Huang N, Li S, Shao Z*, Wu J*. The BMP
inhibitor DAND5 in serum predicts poor survival in breast cancer. Oncotarget,
2016 Mar 22; 7(12):14951-62.
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Chen L, Yang L, Qiao
F, Hu X, Li S, Yao L*,
Yang XL, Shao ZM*. High Levels of Nucleolar Spindle-Associated
Protein and Reduced Levels of BRCA1 Expression Predict Poor Prognosis in
Triple-Negative Breast Cancer. PloS One, 2015 Oct 20; 10(10):e0140572.
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Wang L#, Yao L#,
Zheng YZ, Xu Q, Liu XP, Hu X, Wang P, Shao ZM*. Expression of
autophagy-related proteins ATG5 and FIP200 predicts favorable disease-free
survival in patients with breast cancer. Biochem Biophys Res Commun.,
2015 Mar 20; 458(4):816-22.
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Li K#, Yao L#,
Chen L, Cao ZG, Yu SJ, Kuang XY, Hu X, Shao ZM*. ID2 predicts poor
prognosis in breast cancer, especially in triple-negative breast cancer, and
inhibits E-cadherin expression. Onco Targets Ther., 2014 Jun
18; 7:1083-94.
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Peng WT#, Hu X#, Yao L#,
Jiang YZ, Shao ZM*. Elevated expression of Girdin in the nucleus
indicates worse prognosis for patients with estrogen receptor-positive breast
cancer. Ann Surg Oncol., 2014 Dec; 21.
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1Yao L#, Li K#, Peng W, Lin Q, Li S, Hu X, Zheng
X, Shao Z*. An aberrant spliced transcript of focal adhesion kinase
is exclusively expressed in human breast cancer. J Transl Med.,
2014 May 21; 12:136.
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Huang J#, Yao L#, Xu R, Wu H, Wang M,
White BS, Shalloway D, Zheng X: Activation of
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