姚玲 副研究员 副研究员，博士 E-mail: yaoling@fudan.edu.cn

      2011年毕业于上海交通大学医学院，获生物化学与分子生物学博士学位。毕业后任职于复旦大学附属肿瘤医院肿瘤研究所，乳腺癌研究所。期间于2016-2017年前往美国斯坦福大学医学院访问交流。主持和参加多项国家自然科学基金青年项目和面上项目，参加国家科技支撑计划、上海市科委基础研究项目等。研究成果发表于Nat Communication、The EMBO journal等国际核心杂志。

研究领域：

　　1．乳腺癌相关通路分子异常剪接与乳腺癌转移的关系；
　　2．乳腺癌相关通路分子异常表达及突变与乳腺癌发生发展的关系。

代表性论著：

1. Yao L^#, Liu Y^#, Cao Z, Li J, Huang Y, Hu X, Shao Z^*. MicroRNA 493 is a prognostic factor in triple-negative breast cancer. Cancer Sci., 2018 Jul; 109(7):2294-2301.

   Src and transformation by an RPTPalpha splice mutant found in human tumours. The EMBO journal., 2011; 30(15):3200-3211.

2. Chen L^#, Yang L^#, Yao L^#, Kuang XY, Zuo WJ, Li S, Qiao F, Liu YR, Cao ZG, Zhou SL, Zhou XY, Yang WT, Shi JX, Huang W, Hu X, Shao ZM^*. Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients. Nat Commun., 2018 Apr 10; 9(1):1357. 

3. Yao L^#, Chi Y^#, Hu X^#, Li S, Qiao F, Wu J, Shao ZM^*. Elevated expression of RNA methyltransferase BCDIN3D predicts poor prognosis in breast cancer. Oncotarget, 2016 Aug 16; 7(33):53895-53902.

4. Cao ZG^#, Huang YN^#, Yao L^#, Liu YR, Hu X, Hou YF, Shao ZM^*. Positive expression of miR-361-5p indicates better prognosis for breast cancer patients. J Thorac Dis., 2016 Jul; 8(7):1772-9.

5. Chi Y^#, Yao L^#, Hu X, Huang S, Huang N, Li S, Shao Z^*, Wu J^*. The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer. Oncotarget, 2016 Mar 22; 7(12):14951-62.

6. Chen L, Yang L, Qiao F, Hu X, Li S, Yao L^*, Yang XL, Shao ZM^*. High Levels of Nucleolar Spindle-Associated Protein and Reduced Levels of BRCA1 Expression Predict Poor Prognosis in Triple-Negative Breast Cancer. PloS One, 2015 Oct 20; 10(10):e0140572.

7. Wang L^#, Yao L^#, Zheng YZ, Xu Q, Liu XP, Hu X, Wang P, Shao ZM^*. Expression of autophagy-related proteins ATG5 and FIP200 predicts favorable disease-free survival in patients with breast cancer. Biochem Biophys Res Commun., 2015 Mar 20; 458(4):816-22.

8. Li K^#, Yao L^#, Chen L, Cao ZG, Yu SJ, Kuang XY, Hu X, Shao ZM^*. ID2 predicts poor prognosis in breast cancer, especially in triple-negative breast cancer, and inhibits E-cadherin expression. Onco Targets Ther., 2014 Jun 18; 7:1083-94.

9. Peng WT^#, Hu X^#, Yao L^#, Jiang YZ, Shao ZM^*. Elevated expression of Girdin in the nucleus indicates worse prognosis for patients with estrogen receptor-positive breast cancer. Ann Surg Oncol., 2014 Dec; 21.

10. 1Yao L^#, Li K^#, Peng W, Lin Q, Li S, Hu X, Zheng X, Shao Z^*. An aberrant spliced transcript of focal adhesion kinase is exclusively expressed in human breast cancer. J Transl Med., 2014 May 21; 12:136.

11. Huang J^#, Yao L^#, Xu R, Wu H, Wang M, White BS, Shalloway D, Zheng X: Activation of