副研究员

李焱 副研究员
副研究员,博士
E-mail: liyan927818@163.com
 

  2008年毕业于济宁医学院,获临床医学学士学位。2011年毕业于上海交通大学医学院肿瘤研究所,获肿瘤学硕士学位。2014年毕业于上海交通大学医学院肿瘤研究所,获生物化学与分子生物学博士学位。 2014年7月至今就职于复旦大学附属肿瘤医院/肿瘤研究所。主持项目包括国家自然科学基金青年项目一项,国家自然科学基金面上项目一项,并作为课题骨干参与国家自然科学基金重点项目及面上项目多项。主要研究成果发表于Cell Research,Cancer Letters, Science Signaling, Cell Death and Disease, Methods in Molecular Biology等专业杂志上 。 


研究方向:

  1、非编码RNA (circRNA , miRNA, lncRNA) 在消化道肿瘤中的鉴定、功能及分子机制研究。
  2、肿瘤细胞外泌体中核酸、蛋白的鉴定、功能及其临床意义。


代表性论著:

  1. Li Yan#, Chen Bing, Huang Shenglin*. Identification of circRNAs for miRNA Targets by Argonaute2 RNA Immunoprecipitation and Luciferase Screening Assays. Methods Mol Biol, 2018; 1724:209-218.
  2. Jie Chen#, Yan Li#, Qiupeng Zheng, Chunyang Bao, Jian He, Bing Chen, Dongbin Lyu, Biqiang Zheng, Yu Xu, Ziwen Long, Ye Zhou, Huiyan Zhu, Yanong Wang, Xianghuo He, Yingqiang Shi*, Shenglin Huang*. Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Letters, 2017 Mar 1; 388:208-219.
  3. Zhou Zhenhua#, Li Yan#, Wang Xudong#, Hu Jingjing, Kuang Muyu,Wang Zhiwei, Li Song, Xu Weidong, Xiao Jianru*. ALCAM(+) stromal cells:role in giant cell tumor of bone progression. Cell Death & Disease, 2018 Feb 20; 9(3):299.
  4. Shengli Li, Yuchen Li, Bing Chen, Jingjing Zhao, Shulin Yu, Yan Tang, Qiupeng Zheng, Yan Li, Peng Wang, Xianghuo He, Shenglin Huang*. exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Research, 2018 Jan 4; 46(D1):D106-D112.
  5. Zhou Zhenhua# , Li Yan#, Jia Qi# ,Wang Zhiwei, Wang Xudong, Hu Jingjing, Xiao Jianru*. Heat shock transcription factor 1 promotes the proliferation, migration and invasion of osteosarcoma cells. Cell Prolif, 2017 Aug; 50(4):e12346.   
  6. Zhenhua Zhou#, Yan Li#, Huiqing Wang#, Xudong Wang , Jianru Xiao*. Biological Features of a Renal Cell Carcinoma Cell Line Derived from Spinal Metastasis. DNA Cell Biol, 2017 Feb; 36(2):168-176.
  7. Qiupeng Zheng#, Chunyang Bao#, Weijie Guo, Shuyi Li, Jie Chen, Bin Chen,Yanting Luo, Dongbin Lyu, Yan Li, Guohai Shi, Linhui Liang, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nature Communications, 2016 Apr 6; 7:11215.
  8. Yan Li#, Qiupeng Zheng#, Chunyang Bao, Shuyi Li, Weijie Guo, Jiang Zhao, Di Chen, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Research, 2015 Aug; 25(8):981-4.
  9. Chunyang Bao#, Yan Li#, Lin Huan, Yuannv Zhang, Fangyu Zhao, Qifeng Wang, Linhui Liang, Jie Ding, Li Liu, Taoyang Chen, Jinjun Li, Ming Yao, Shenglin Huang*, Xianghuo He*. NF-kB signaling relieves negative regulation by miR-194 in hepatocellular carcinoma by suppressing the transcription factor HNF-1a. Science Signaling, 2015 Jul 28; 8(387):ra75.  
  10. Li Y#, Xu D#, Bao C#, Zhang Y, Chen D, Zhao F, Ding J, Liang L, Wang Q, Liu L, Li J, Yao M, Huang S*, He X*. MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma. Oncotarget, 2015 Feb 10; 6(4):2421-333.
 
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