王嘉 青年研究员 青年研究员，博士 E-mail: wang_jia@fudan.edu.cn

　　2009年毕业于扬州大学获得生物学专业学士学位，2015年获上海交通大学生物学专业博士学位；2015-2017年在美国哥伦比亚大学从事博士后研究，2017年8月-2020年12月在上海交通大学医学院附属仁济医院任职助理研究员，2021年4月通过人才引进方式加入复旦大学附属肿瘤医院。2019年入选上海市青年东方学者人才计划。研究领域主要集中在肿瘤异质性的单细胞水平研究。主要在细胞和肿瘤学相关研究成果发表在Cancer Cell, Cell Reports, Nature Communications, BMC Biology, Communications Biology, Cell Death and Disease, Cell Proliferation等杂志上。

研究领域：

　　1.    肿瘤细胞起源和分子分型的单细胞分析
　　2.    肿瘤免疫治疗机理的单细胞分析

代表性论著：

1.    Lai Huadong^#, Cheng Xiaomu^#, Liu Qiang, Luo Wenqin, Liu Mengyao, Zhang  Man, Miao Juju, Ji Zhongzhong. Lin Guan Ning, Song Weichen, Zhang Lianhua, Bo  Juanjie, Yang Guoliang^*, Wang Jia^*, Gao Wei-Qiang^*. Single-cell RNA sequencing reveals the epithelial cell heterogeneity and invasive subpopulation in human bladder cancer. International Journal of Cancer. 2021 Sep 3.

2. Xiaomu Cheng^#, Huadong Lai, Wenqin Luo, Man Zhang, Juju Miao, Weichen Song, Shunpeng Xing^*, Jia Wang^*, Wei-Qiang Gao^*. Single-cell analysis reveals urothelial cell heterogeneity and regenerative cues following cyclophosphamide-induced bladder injury. Cell Death Dis，2021 May 5;12(5):446.

3. Wenqin Luo^#, Weichen Song^#, GN Lin^#, Yu Zhang, Huadong Lai, Man Zhang, Juju Miao, Xiaomu Cheng, Yongjie Wang, Wenxiang Wei, Wei-Qiang Gao*, Ru Yang*, Jia Wang*. Single-cell spatial transcriptomic analysis reveals common and divergent features of developing postnatal granule cerebellar cells and medulloblastoma. BMC Biology，2021 Jul 1;19(1):135.

4. Dong Baijun#, Juju Miao#, Yanqing Wang#, Wenqin Luo, Zhongzhong Ji, Huadong Lai, Man Zhang, Xiaomu Cheng, Jinming Wang, Yuxiang Fang, Helen He Zhu, Chee Wai Chua, Liancheng Fan, Yinjie Zhu, Jiahua Pan, Jia Wang^*, Wei Xue^*, Wei-Qiang Gao^*. Single-cell analysis supports a luminalneuroendocrine
transdifferentiation in human prostate cancer. Communications Biology, 2020 Dec 16; 3(1):778.

5. Rui Dong^*, Ran Yang, Yong Zhan, Hua-Dong Lai, Chun-Jing Ye, Xiao-Ying Yao, Wen-Qin Luo, Xiao-Mu Cheng, Ju-Ju Miao, Jun-Feng Wang, Bai-Hui Liu, Xiang-Qi Liu, Lu-Lu Xie, Wei-Qiang Gao,Yun-Hui Tang, Chun-Yan Shen, Wei Jiang, Gong Chen, Wei Yao, Kui-Ran Dong, Xian-Min Xiao, Shan Zheng, Kai Li^*, Jia Wang^*. Single-cell characterization of malignant phenotypes and development trajectories of adrenal neuroblastoma. Cancer Cell, 2020 Nov 9; 38(5):716-733.e6.

6. Yu Zhang^#, Yongfang Li^#, Wenqin Luo, Yaohui Tang, Jia Wang^*, Ru Yang^*, Wei-Qiang Gao^*. Histological, cellular and behavioural analyses of effects of chemotherapeutic agent cyclophosphamide in the developing cerebellum. Cell Proliferation. 2019 May; 52(3):e12608.

7. Wang J^#, Batourina E^#, Schneider K, Souza S, Swayne T, Liu C, George CD, Tate T, Dan H, Wiessner G, Zhuravlev Y, Canman JC, Mysorekar IU, Mendelsohn CL^*. Polyploid Superficial Cells that Maintain the Urothelial Barrier Are Produced via Incomplete Cytokinesis and Endoreplication. Cell Reports，2018 Oct 9; 25(2):464-477.

8. Jia Wang^#, Helen He Zhu, Mingliang Chu, Yunying Liu, Chenxi Zhang, Geng Liu, Xiaohang Yang, Ru Yang & Wei-Qiang Gao^*. Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages. Nat Communications. 2014 Aug 28; 5:4758.