卫功宏 教授 教授，博士生导师 E-mail: gonghong_wei@fudan.edu.cn

　　卫功宏，复旦大学特聘教授，博士生导师，国家与上海市“海外高层次人才引进计划”入选者。2006年博士毕业于北京协和医学院；随后于赫尔辛基大学医学院从事博士后研究；2011-2019年任职奥卢大学医学院，独立PI，历任青年研究员、副教授、正教授；2014-2019任芬兰科学院研究员。研究方向为癌症遗传学与基因组学，代表性学术成果以通讯作者（含共同）在Cell、Nature Genetics、Nature Communications、Clinical Cancer Research、Cancer Research等杂志发表。研究工作曾受到知名国际杂志Nature Genetics, Cancer Discovery, Nature Reviews Urology等和Faculty of 1000的关注与点评，以及 Science Daily，赫尔辛基日报等媒体的报道。多次受邀为Nature Genetics、Nature Communications、Genome Research、Cell Research、Theranostics、Science Bulletin等四十多种学术杂志审稿。曾分别获得奥卢大学生物中心2014，2016和2018年度发现奖，2014和2018年度芬兰生物医学与临床科学领域最佳论文奖（Medix Prize 2015；2019）；指导的博士生曾分别获得2016年度芬兰奥卢大学医学部最佳博士论文奖和2019年度国家自费留学奖学金，目前已培养的1名博士后和1名博士生分别任国内重点大学教授与博士生导师。

研究领域：

　主要从事恶性泌尿肿瘤、乳腺癌、肺癌、消化道肿瘤等易感、发生发展和转移的生物学机制与整合组学研究，并探讨潜在的临床转化应用。

研究团队：

代表性论著：

1. Tian P#, Zhong M#, Wei GH*. Mechanistic insights into genetic susceptibility to prostate cancer. Cancer Letters. 2021 Sep 22; 522:155-163.

2. Ahmed M#, Soares F#, Xia JH#, Yang Y, Li J, Guo H, Su P, Tian Y, Lee JH, Wang M, Akhtar N, Houlahan KE, Bosch A, Zhou S, Mazrooei P, Hua J, Chen S, Petricca J, Zeng Y, Davies A, Fraser M, Quigley DA, Feng F, Boutros PC, Lupien M, Zoubeidi A, Wang L, Walsh MJ, Wang T, Ren S*, Wei GH*, He HH*. CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer, Nature Communications. 2021 Mar 19; 12(1):1781.

3. Sipeky C#, Gao P#, Zhang Q, Wang L, Ettala O, Talala K, Tammela TL, Auvinen A, Wiklund F, Wei GH*, Schleutker J*. Synergistic interaction of HOXB13 and CIP2A predispose to aggressive prostate cancer. Clinical Cancer Research. 2018 Dec 15; 24(24):6265-6276.

4. Gao P#, Xia JH#, Sipeky C, Dong XM, Zhang Q, Yang Y, Zhang P, Cruz SP, Zhang K, Zhu J, Lee HM, Suleman S, Giannareas N, Liu S; PRACTICAL Consortium, Tammela TLJ, Auvinen A, Wang X, Huang Q, Wang L, Manninen A, Vaarala MH, Wang L, Schleutker J, Wei GH*. Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus. Cell. 2018 Jul 26; 174(3):576-589.

Previewed in Bulger M. Changing the Guard at a Prostate Cancer SNP. Cell. 174:501-502, 2018
Highlighted in Bradley C. Mechanistic insights into a non-coding risk SNP. Nature Reviews Urology 15:655, 2018
Invited author's views: Xia JH & Wei GH. Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness. Molecular & Cellular Oncology. 5(6):e1516451. 2018

5. Zhang B*, Chen MY, Shen YJ, Zhuo XB, Gao P, Zhou FS, Liang B, Zu J, Zhang Q, Suleman S, Xu YH, Xu MG, Xu JK, Liu CC, Giannareas N, Xia JH, Zhao Y, Huang ZL, Yang Z, Cheng HD, Li N, Hong YY, Li W, Zhang MJ, Yu KD, Li G, Sun MH, Chen ZD, Wei GH*, Shao ZM*. A Large-Scale, Exome-Wide Association Study of Han Chinese Women Identifies Three Novel Loci Predisposing to Breast Cancer. Cancer Research. 2018 Jun 1; 78(11):3087-3097.

6. Zhang P#, Xia J#, Zhu J, Gao P, Tian YJ, Du M, Guo CY, Suleman S, Zhang Q, Kohli M, Tillmans L, Thibodeau SN, French AJ, Cerhan JR, Wang LD*, Wei GH*, Wang L*. High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing.Nature Communications. 2018 May 22; 9(1):2022.

7. Whitington T*#, Gao P#, Song W, Ross-Adams H, Lamb AD, Yang Y, Svezia I, Klevebring D, Mills IG, Karlsson R, Halim S, Dunning MJ, Egevad L, Warren AY, Neal DE, Grönberg H, Lindberg J, Wei GH (joint supervision), Wiklund F. Gene regulatory mechanisms underpinning prostate cancer susceptibility. Nature Genetics. 2016 Apr; 48(4):387-97.

Research Watch Prostate Cancer Risk Loci Are Associated with Gene Regulatory Mechanisms. Cancer Discovery 6:OF13, 2016

8.Huang Q#, Whitington T#, Gao P, Lindberg JF, Yang Y, Sun J, Väisänen MR, Szulkin R, Annala M, Yan J, Egevad LA, Zhang K, Lin R, Jolma A, Nykter M, Manninen A, Wiklund F, Vaarala MH, Visakorpi T, Xu J, Taipale J*, Wei GH*. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. Nature Genetics. 2014 Feb; 6(2):126-35.

Previewed in HOXB13, RFX6 and prostate cancer risk. Nature Genetics. 46:94-95, 2014
Highlighted in Prostate cancer: HOXB13 and a SNP collaborate to increase risk. Nature Reviews Urology. 11:64, 2014
Research Watch A Prostate Cancer–Associated SNP Increases HOXB13 Binding. Cancer Discovery 4:268, 2014
Recommended by Faculty of 1000: ★★ Very Good, good for teaching, new finding. In F1000Prime, 27 Jan 2014; DOI: 10.3410/f.718228195.793490008
News in JNCI: Journal of the National Cancer Institute, 2014
Eturauhassyöpään johtava geenimuutos löytyi Oulussa. HELSINGIN SANOMAT Jan 10 2014

9. Wei GH#, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J*. Genome-Wide Analysis of ETS Family DNA-Binding in vitro and in vivo. EMBO Journal. 2010 Jul 7; 29(13):2147-60.

10. Wei GH#, Liu DP*, Liang CC. Charting gene regulatory networks: strategies, challenges and perspectives. Biochem Journal. 2004 Jul 1; 381(Pt 1):1-12.