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2014年获辽宁大生命科学院学士学位,2019年获复旦大学生物医学研究院博士学位,同年入职复旦大学附属肿瘤医院任助理研究员,2022年1月至今,任职于复旦大学附属肿瘤医院和生命科学学院青年研究员(双聘)。2022年入选中国科协第七届“青年人才托举工程”。
研究方向是利用生化和结构生物学的方法,研究真核生物基因转录过程中关键蛋白复合物的结构和功能,探索转录的调控机制。以第一作者或共同通讯作者在Science,Cell Research,Nature Communications,Cell Reports等国际核心期刊发表多篇论文。
研究领域:
真核生物基因转录的调控机制
代表性论著:
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Chen, X. #, Yin, X. #, Li, J. #, Wu, Z. #, Qi, Y. #, Wang, X. #, Liu, W., and Xu, Y*. Structures of the human Mediator and Mediator-bound preinitiation complex. Science. 2021 Jun 4; 372(6546):eabg0635.
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Chen, X. #, Qi, Y.#, Wu, Z#., Wang, X. #, Li, J. #, Zhao, D. #, Hou, H. #, Li, Y., Yu, Z., Liu, W., Wang, M., Ren, Y., Li, Z., Yang, H., and Xu, Y*. Structural insights into preinitiation complex assembly on core promoters. Science. 2021 Apr 30; 372(6541):eaba8490.
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Wang, X. #, Qi, Y. #, Wang, Z. #, Wang, L. #, Song, A. #, Tao, B., Li, J., Zhao, D., Zhang, H., Jin, Q., Jiang, Y., Chen, F. X.*, Xu, Y.*; and Chen, X. * RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex. Cell Reports. 2022 Apr 26; 39(4):110732.
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Chen, X. #, Liu, M. #, Tian, Y., Li, J., Qi, Y., Zhao, D., Wu, Z., Huang, M., Wong, C. C. L., Wang, H. W., Wang, J., Yang, H.*, and Xu, Y*. Cryo-EM structure of human mTOR complex 2. Cell Research. 2018 May; 28(5):518-528.
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Yang, H. #, Yu, Z. #, Chen, X. #, Li, J., Li, N., Cheng, J., Gao, N., Yuan, H. X., Ye, D., Guan, K. L., and Xu, Y*. Structural insights into TSC complex assembly and GAP activity on Rheb. Nature Communications .2021 Jan 12; 12(1):339.
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Yang, H. #, Wang, J#, Liu, M.#, Chen, X. #, Huang, M., Tan, D., Dong, M. Q., Wong, C. C., Wang, J*., Xu, Y.*, and Wang, H. W*. 4.4 A Resolution Cryo-EM structure of human mTOR Complex 1. Protein & cell . 2016 Dec; 7(12):878-887.
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Zheng, H. #, Qi, Y. #, Hu, S. #, Cao, X. #, Xu, C. #, Yin, Z., Chen, X., Li, Y., Liu, W., Li, J., Wang, J., Wei, G., Liang, K., Chen, F. X.*, and Xu, Y*. Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase. Science. 2020 Nov 27; 370(6520):eabb5872.
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