秦毅 研究员 博士，研究员 E-mail: qinyi@fudanpci.org

　　2003年本科毕业于吉林大学/沈阳药科大学，2011年毕业于中国科学院生物化学与细胞生物学研究所，博士学位。曾于2011年-2012年在复旦大学分子病毒实验室工作。自2012年起，一直在复旦大学肿瘤研究所/胰腺肿瘤研究所工作，2018年晋升为副研究员。主要从事胰腺癌的临床和基础研究，科研重点为胰腺癌的转化研究和胰腺癌转移机制研究等，已发表有关胰腺癌研究的SCI论著近20余篇。先后主持及参与上海科委自然科学基金，国家自然科学基金，国家杰青基金及其他省部级项目10余项。

研究领域：

　　胰腺癌的转化研究和胰腺癌转移机制研究，主要研究方向如下：
　　1. 驱动基因KRAS突变促进胰腺癌侵袭转移的分子机制; 
　　2. 抑癌基因FBW7在胰腺癌中的功能；
　　3. 肿瘤代谢异常调控胰腺癌恶性潜能的分子机制。

代表性论著：

1. Liang C^#, Shi S^#, Qin Y^#, Meng Q, Hua J, Hu Q, Ji S, Zhang B, Xu J, Yu XJ. Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer. Gut, 2019 Oct 14.
   
2. Qin Y^#, Hu Q^#, Ji S, Xu J, Dai W, Liu W, Xu W, Sun Q, Zhang Z, Ni Q, Yu X, Zhang B, Xu X. Homeodomain-interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer. Cell Prolif, 2019 May.
   
3. Qin Y^#, Hu Q^#, Xu J^#, Ji S, Dai W, Liu W, Xu W, Sun Q, Zhang Z, Ni Q, Zhang B, Yu X, Xu X PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis.  Cell Commun Signal, 2019 Mar.
   
4. Hu Q^#, Qin Y^#, Ji S^#, Xu W, Liu W, Sun Q, Zhang Z, Liu M, Ni Q, Yu X, Xu X. UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer. Cancer Lett, 2019 Jun.
5. Qiangsheng Hu^#, Yi Qin^#, Jinfeng Xiang#, Wensheng Liu, Wenyan Xu, Qiqing Sun, Shunrong Ji, Jiang Liu, Zheng Zhang, Quanxing Ni, Jin Xu, Xianjun Yu^*, Bo Zhang^*. dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer. Cell Proliferation, 2018; Apr 27: e12456. doi: 10.1111/cpr.12456. [Epub ahead of print]
6. Chen Liang^#, Yi Qin^#, Bo Zhang#, Shunrong Ji, Si Shi, Wenyan Xu, Jiang Liu, Jinfeng Xiang, Dingkong Liang, Qiangsheng Hu, Quanxing Ni, Jin Xu, and Xianjun Yu^*. Oncogenic KRAS Targets MUC16/CA125 in Pancreatic Ductal Adenocarcinoma. Molecular Cancer Research, 2017; 15(2):201-212.
7. Qiangsheng Hu^#, Yi Qin^#, Bo Zhang^#, Chen Liang, Shunrong Ji, Si Shi, Wenyan Xu, Jinfeng Xiang, Dingkong Liang, Quanxing Ni, Xianjun Yu^*, Jin Xu^*. FBW7 increases the chemosensitivity of pancreatic cancer cells to gemcitabine through upregulation of ENT1. Oncology Reports, 2017; 38(4):2069-2077.
8. Shunrong Ji^#, Yi Qin^#, Chen Liang^#, Run Huang, Si Shi, Jiang Liu, Kaizhou Jin, Dingkong Liang, Wenyan Xu, Bo Zhang, Liang Liu, Chen Liu, Jin Xu, Quanxing Ni, Paul J. Chiao, Min Li, and Xianjun Yu^*. FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer. Clinical Cancer Research, 2016; 22(15):3950-60.
9. Chen Liang^#, Yi Qin^#, Bo Zhang^#, Shunrong Ji, Si Shi, Wenyan Xu, Jiang Liu, Jinfeng Xiang, Dingkong Liang, Qiangsheng Hu, Quanxing Ni, Xianjun Yu^*, Jin Xu^*. ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer. Cancer Letters, 2016; 388:303-311.
10. Chen Liang^#, Yi Qin^#, Bo Zhang, Shunrong Ji, Si Shi, Wenyan Xu, Jiang Liu, Jinfeng Xiang, Dingkong Liang, Qiangsheng Hu, Liang Liu, Chen Liu, Guopei Luo, Quanxing Ni, Jin Xu^*, and Xianjun Yu^*. Energy sources identify metabolic phenotypes in pancreatic cancer. Acta Biochim Biophys Sin, 2016; 48(11):969-979.
11. Chen Liang^#, Yi Qin^#, Bo Zhang, Shunrong Ji, Si Shi, Wenyan Xu, Jiang Liu, Jinfeng Xiang, Dingkong Liang, Qiangsheng Hu, Quanxing Ni, Jin Xu, Xianjun Yu^*. Metabolic plasticity in heterogeneous pancreatic ductal adenocarcinoma. Biochimica et Biophysica Acta, 2016; 1866(2):177-188.
12. B. Zhang^#, J. Xu^#, C. Li^#, S. Shi, S. Ji, W. Xu, J. Liu, K. Jin, D. Liang, C. Liang, L. Liu, C. Liu, Y. Qin^* and X. Yu^*. MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer. Current Molecular Medicine, 2016; 16(4):404-11.
13. S. Shi^#, J. Xu^#, B. Zhang, S. Ji, W. Xu, J. Liu, K. Jin, D. Liang, C. Liang, L. Liu, C. Liu, Y. Qin^* and X. Yu^*. VEGF Promotes Glycolysis in Pancreatic Cancer via HIF1α Up-Regulatio. Current Molecular Medicine,2016; 16(4):394-403.
14. Qingguo Li^#, Yi Qin^# Ping Wei, Peng Lian, Yaqi Li, Ye Xu, Xinxiang Li, Dawei Li, and Sanjun Cai^*. Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma, Molecular Cancer Research, 2016; 14(9):830-40.
15. Qing-Hai Ye^# ,Wen-Wei Zhu^#, Ju-Bo Zhang^#, Yi Qin^#, Ming Lu, Guo-Ling Lin, Lei Guo, Bo Zhang, Zhen-Hai Lin, Stephanie Roessler, Marshonna Forgues,Hu-Liang Jia, Lu Lu, Xiao-Fei Zhang, Bao-Feng Lian, Lu Xie,Qiong-Zhu Dong, Zhao-You Tang,Xin Wei Wang^*,and Lun-Xiu Qin^*. GOLM1 Modulates EGFR/RTK Cell-Surface Recycling to Drive Hepatocellular Carcinoma Metastasis. Cancer Cell, 2016; 30(3):444-58.
16. Shunrong Ji^#, Yi Qin^#, Si Shi, Xiangyuan Liu, Hongli Hu, Hu Zhou, Jing Gao, Bo Zhang, Wenyan Xu, Jiang Liu, Dingkong Liang, Liang Liu, Chen Liu, Jiang Long, Haijun Zhou, Paul J Chiao, Jin Xu, Quanxing Ni, Daming Gao, Xianjun Yu^*. ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. Cell Research, 2015; 25(5):561-73.
17. Si Shi^#, Shunrong Ji^#, Yi Qin^#, Jin Xu, Bo Zhang, Wenyan Xu, Jiang Liu, Jiang Long, Chen Liu, Liang Liu, Quanxing Ni, Xianjun Yu^*. Metabolic tumor burden is associated with major oncogenomic alterations and serum tumor markers in patients with resected pancreatic cancer. Cancer Letters, 2015; 360(2):227-33.
18. Wantong Yao^#, Shunrong Ji^#, Yi Qin^#, Jingxuan Yang, Jin Xu, Bo Zhang, Wenyan Xu, Jiang Liu, Si Shi, Liang Liu, Chen Liu, Jiang Long, Quanxing Ni, Min Li and Xianjun Yu^*. Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis. Molecular Cancer, 2014; 13:187.
19. Yi Qin^#, Wenwei Zhu^# , Wenyan Xu^#, Bo Zhang, Si Shi, Shunrong Ji, Jiang Liu, Jiang Long, Chen Liu, Liang Liu , Jin Xu^*, Xianjun Yu^*. LSD1 sustains pancreatic cancer growth via maintaining HIF1a-dependent glycolytic process. Cancer Letters, 2014; 347(2):225-32.
20. Yanfeng Liu^#, Ju-Bo Zhang^#, Yi Qin^#, Wei Wang, Lili Wei, Yigang Teng, Lei Guo, Bo Zhang, Zhenhai Lin, Jing Liu, Zheng-Gang Ren, Qing-Hai Ye, and Youhua Xie^*. PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating Hypoxia-Inducible Factor 1a expression and protein stability. Hepatology, 2013; 58(2):692-705.