吴炅 教授 教授，博士生导师 E-mail: wujiong1122@vip.sina.com

　　1993年与1998年分别获复旦大学上海医学院 (原上海医科大学) 医学学士学位和肿瘤学博士学位。1998年获UICC ICRETT资助赴美国加州大学洛杉矶分校，研究乳腺肌上皮细胞旁分泌对乳腺癌生长与浸润的作用。2004年7月赴美国Texas, Houston, M.D. Anderson肿瘤中心整形外科进修一期乳房重建手术。2008年起任复旦大学肿瘤医院乳腺外科主任医师，现任复旦大学附属肿瘤医院业务副院长，中国抗癌协会乳腺癌专业委员会候任主任委员，上海市医学会肿瘤靶分子专科分会主任委员，教授，博士生导师。2004年以第三完成人获国家科技进步二等奖（乳腺癌的临床和基础研究），作为第三完成人于2002年和2003年2次获得上海市科技进步二等奖；作为主要参与者2次获得上海市科技进步三等奖；先后获上海市卫生局首批"医苑新星"、上海市卫生局先进工作者、复旦大学"世纪之星"、上海市科技启明星、上海市教委曙光计划等人才基金资助。在国内外刊物上共发表论文200余篇，以第一作者及通讯作者身份发表SCI论文70余篇。参与撰写《现代乳腺肿瘤学进展》（2002年）、《乳腺肿瘤学》（2005年）等。目前正承担国家重大慢病非传染性疾病防控研究课题、上海市科委优秀学术带头人计划、国家自然科学基金面上项目等研究。

研究领域：

　　致力于开展基因标志物在乳腺癌早期诊断、预后及疗效预测中的价值等基础研究；积极应用、推广新的外科技术，诸如前哨淋巴结活检、乳房重建手术，丰富及完善肿瘤-整复领域临床研究。

研究团队：

　　研究生：   王嘉、侯剑晶、桑雨廷、周旭婕、季玮儒、李培、吴芷菀、张琪、陈铭、吴可、邵鼎轶、李寒露、马雨薇、郑舒月

代表性论著：

1. Li L, Su Y, Xiu B, Huang X, Chi W, Hou J, Zhang Y, Tian J, Wang J, Wu J*. Comparison of prepectoral and subpectoral breast reconstruction after mastectomies: A systematic review and meta analysis. Eur J Surg Oncol, 2019 Sep; 45(9):1542-1550.
2. Rong Guo, Lun Li, Yonghui Su, Bingqiu Xiu, Qi Zhang, Jia Wang, Weiru Chi, Benlong Yang, Yingying Zhang, Ayong Cao, Zhimin Shao, Jiong Wu*. Current practice and barriers of mesh-assisted implant-based breast reconstruction in China: A nationwide cross-sectional survey of 110 hospitals. Eur J Surg Oncol, 2019 Sep.
   
3. Yayun Chi^#, Jingyan Xue^#, Sheng Huang^#, Bingqiu Xiu^#, Yonghui Su, Wei Wang, Rong Guo, Lei Wang, Lun Li, Zhiming Shao, Wei Jin, Zhaohui Wu*, Jiong Wu*. CapG promotes resistance to paclitaxel in breast cancer through transactivation of PIK3R1/P50. Theranostics,   doi:10.7150/thno.36338.
   
4. Sheng Huang^#, Yayun Chi^#, Yi Qin^#, Ziliang Wang, Bingqiu Xiu, Yonghui Su, Rong Guo, Liang Guo, Hefen Sun, Chujia Zeng, Shuling Zhou, Xin Hu, Sheng Liu, Zhimin Shao, Zhaohui Wu, Wei Jin, Jiong Wu^*. CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription. Theranostics, 2018; 8(9): 2549-2564.
5. Guo L, Chi Y, Xue J, Ma L, Shao Z, Wu J^*. Phosphorylated eIF2α predicts disease-free survival in triple-negative breast cancer patients. Sci Rep, 2017; 7:44674.
6. Huang NS, Quan CL, Mo M, Chen JJ, Yang BL, Huang XY, Wu J^*. A prospective study of breast anthropomorphic measurements, volume and ptosis in 605 Asian patients with breast cancer or benign breast disease. PLoS One, 2017; 12(2):e0172122.
7. Xue J^#, Chi Y^#, Chen Y, Huang S, Ye X, Niu J, Wang W, Pfeffer L M, Shao Z-M, Wu Z-H^*, Wu J^*. MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity. Oncogene, 2016; 35(4):448-458.
8. Lou Feifei^#, Sun Zhirong, Huang Naisi, Hu Zhen, Cao Ayong, Shen Zhenzhou, Shao Zhimin, Yu Peirong, Miao Changhong, Wu Jiong^*. Epidural Combined with General Anesthesia versus General Anesthesia Alone in Patients Undergoing Free Flap Breast Reconstruction. Plastic and Reconstructive Surgery, 2016; 137(3):502e-509e.
9. Niu, J^#, Xue A, Chi Y, Xue J, Wang W, Zhao Z, Fan M, Yang CH, Shao Z-M, Pfeffer L M, Wu J^*, Wu Z-H^*. Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer. Oncogene, 2016 Mar 10; 35(10):1302-13.
10. Chen Jia-ying^#, Chen Jia-jian, Xue Jing-yan, Chen Ying, Liu Guang-yu, Han Qi-xia, Yang Wen-tao, Shen Zhen-zhou, Shao Zhi-min, Wu Jiong^*. Predicting Non-sentinel Lymph Node Metastasis in a Chinese Breast Cancer Population with 1-2 Positive Sentinel Nodes: Development and Assessment of a New Predictive Nomogram. World J Surg, 2015; 39(12):2919-2927.
11. Huang Naisi^#,Chen Jiajian, Xue Jingyan, Yu Baohua, Chen Yanqiong, Yang Wentao, Shao Zhimin, Wu Jiong^*. Breast Sclerosing Adenosis and Accompanying Malignancies: A Clinicopathological and Imaging Study in a Chinese Population. Medicine (Baltimore), 2015; 94(49):e2298-e2298.
12. Huang Nai-Si^#, Wu Jiong^*. Nipple-sparing Mastectomy in Breast Cancer: From an Oncologic Safety Perspective. Chin Med J (Engl), 2015; 128(16):2256-2261.
13. Jia-jian Chen^#, Nai-si Huang^#, Jing-yan Xue, Ben-long Yang, Guang-yu Liu, Gen-hong Di, Zhi-min Shao, Jiong Wu^*. Current Status of Breast Reconstruction in Southern China: A 15 Year, Single Institutional Experience of 20,551 Breast Cancer Patients. Medicine (Baltimore), 2015; 94(34):e1399-e1399.
14. Huang Xiaoyan^#, Dugo Matteo, Callari Maurizio, Sandri Marco, De Cecco Loris, Valeri Barbara, Carcangiu Maria Luisa, Xue Jingyan, Bi Rui, Veneroni Silvia, Daidone Maria Grazia, Menard Sylvie, Tagliabue Elda, Shao Zhimin, Wu Jiong^*, Orlandi, Rosaria^*. Molecular portrait of breast cancer in China reveals comprehensive transcriptomic likeness to Caucasian breast cancer and low prevalence of luminal A subtype. Cancer Med, 2015; 4(7):1016-1030.
15. Jiang Hong-Lin^#, Sun He-Fen, Gao Shui-Ping, Li Liang-Dong, Hu Xin, Wu Jiong^*, Jin Wei^*. Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-beta/SMAD signaling. Oncotarget, 2015; 6(18):16352-16365.
16. Naisi Huang^#, Mengying Liu, Peirong Yu, Jiong Wu^*. Antibiotic prophylaxis in prosthesis-based mammoplasty: A systematic review. International Journal of Surgery, 2015; 15:31-37.
17. Chen Ying^#, Shen Zhenzhou, Shao Zhimin, Yu Peirong, Wu Jiong^*. Free Flap Monitoring Using Near-Infrared Spectroscopy: A Systemic Review. Annals of Plastic Surgery, 2015; 1(1).
18. Chen Jia-jian^#, Huang Nai-si, Xue Jing-yan, Quan Chen-lian,Tan Yu-long, Liu Guang-yu, Shao Zhi-min, Wu Jiong^*. Surgical management for early-stage bilateral breast cancer patients in China. PLos One, 2015; 10(4):e0122692-e0122692.
19. Chi Yayun^#, Huang Sheng, Peng Haojie,Liu Mengying, Zhao Jun, Shao Zhiming, Wu Jiong^*. Critical role of CDK11(p58) in human breast cancer growth and angiogenesis. BMC Cancer, 2015; 15:701-701.
20. Niu Jixiao^#, Shi Yuling, Xue Jingyan, Miao Ruidong, Huang Shengping, Wang Tianyi, Wu Jiong, Fu Mingui, Wu Zhao-Hui. USP10 inhibits genotoxic NF-kappaB activation by MCPIP1-facilitated deubiquitination of NEMO. The EMBO Journal, 2013; 32(24):3206-3219.