临床PI
郭小毛 教授
教授,博士生导师
E-mail: guoxm1800@126.com
 

  1993年毕业于上海医科大学获肿瘤学硕士学位,2009年赴美国M.D.安德森肿瘤中心做访问学者。擅长于乳腺肿瘤和腹部肿瘤的放射治疗,尤其在乳腺癌、前列腺癌等肿瘤疾病的放射治疗及综合治疗方面有较深入的研究。现任复旦大学附属肿瘤医院院长、上海市质子重离子医院(复旦大学附属肿瘤医院质子重离子中心)院长,中国抗癌协会副理事长、中国抗癌协会肿瘤放射治疗专业委员会主任委员。曾承担多个市级科委科研项目及国家自然科学基金。先后在国内外肿瘤权威杂志发表论文60余篇。


研究领域:

  1.乳腺癌的临床与转化性研究
   开展早期乳腺癌保乳术后部分乳腺照射、全乳大分割放疗、乳腺癌粒子治疗等前瞻性研究;着力于前列腺癌和乳腺癌转化性研究,尤其在不同分子分型的乳腺细胞的放疗敏感性差异及放射增敏剂应用等方面有着深入研究。
  2.质子重离子的临床与转化性研究
  质子和重离子放疗是目前最尖端的放疗技术。复旦大学附属肿瘤医院质子重离子中心/上海市质子重离子医院于2015年5月正式投入使用,是国际上第三个同时拥有质子和重离子放疗系统的医疗单位,目前已治疗各类肿瘤患者千余例。着眼于“精准医疗”,以乳腺癌和前列腺的质子、重离子放疗技术临床个体化应用为核心,明确基于生物影像和组学特征谱的多线束精准放疗的适应人群。


代表性论著:

  1. Wei Y#, Li C#, Bian H, Qian W, Jin K, Xu T, Guo X*, Lu X*, Su F*. Targeting CDK7 suppresses super enhancer-linked inflammatory genes and alleviates CAR T cell-induced cytokine release syndrome. Mol Cancer. 2021 Jan 4; 20(1):5.
  2. Yang Y#, Luo J#, Chen X, Yang Z, Mei X, Ma J, Zhang Z, Guo X*, Yu X*. CDK4/6 inhibitors: a novel strategy for tumor radiosensitization. J Exp Clin Cancer Res. 2020 Sep 15; 39(1):188.
  3. Wang J#, Luo J, Jin K, Wang X, Yang Z, Ma J, Mei X, Wang X, Zhou Z, Yu X*, Chen X*, Guo X*. Biological subtype predicts locoregional recurrence after postmastectomy radiotherapy in Chinese breast cancer patients. Cancer Med. 2020 Apr; 9(7):2427-2434.
  4. Xie L#, Bao X*, Cai T, Silva SG, Ma J, Zhang Z, Guo X*, Marks LB. Elevated Risk of Radiation Therapy-Associated Second Malignant Neoplasms in Young African-American Women Survivors of Stage I-IIIA Breast Cancer. Int J Radiat Oncol Biol Phys. 2019 Oct 1; 105(2):275-284.
  5. Zhang L#, Jin K#, Wang X, Yang Z, Wang J, Ma J, Mei X, Chen X, Wang X, Zhou Z, Luo J, Wu J, Shao Z, Zhang Z, Yu X*, Guo X*. The Impact of Radiotherapy on Reoperation Rates in Patients Undergoing Mastectomy and Breast Reconstruction. Ann Surg Oncol. 2019 Apr; 26(4):961-968.
  6. Luo J#, Jin K#, Chen X#, Wang X, Yang Z, Zhang L, Mei X, Ma J, Zhang X, Zhou Z, Wang X, Jiang Y, Shao Z, Zhang Z, Guo X*, Yu X*. Internal Mammary Node Irradiation (IMNI) Improves Survival Outcome for Patients with Clinical Stage II-III Breast Cancer After Preoperative Systemic Therapy. Int J Radiat Oncol Biol Phys. 2019 Mar 15; 103(4):895-904.
  7. Luo J#, Jin K#, Qian S, Ma X, Pan Z, Yao W, Zhang Z, Guo X*, Yu X*. Single institution experience of split course radiotherapy in patients with desmoid tumors. Onco Targets Ther. 2019 Mar 7; 12: 1741-1748.
  8. Zhou Z#, Wang C#, Sun X#, Yang Z, Chen X, Shao Z, Yu X*, Guo X*. Prognostic factors in breast phyllodes tumors: a nomogram based on a retrospective cohort study of 404 patients. Cancer Med. 2018 Apr; 7(4):1030–1042.
  9. Zhou Z#, Yang Z, Yu X*, Guo X*. Highlights on molecular targets for radiosensitization of breast cancer cells: Current research status and prospects. Cancer Med, 2018Jul; 7(7):3110–3117.
  10. Chen X#, Yu X#, Chen J, Zhang Z, Tuan J, Shao Z, Guo X*, Feng Y. Analysis in early stage triple-negative breast cancer treated with mastectomy without adjuvant radiotherapy: Patterns of failure and prognostic factors. Cancer, 2013Jul 1; 119(13):2366-74.


 
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